Abstract
The application of neutron activation analysis in five analytical and
occupational health studies is illustrated the present work.In all of the five
studies the multielement analysis of small size biological samples is
performed by neutron activation analysis.The analytical aspects concerning
sampling and sample handling prior to neutron activation analysis with
particular emphasis on contamination problems will be discussed.Irradiation
and the measuring of biological samples in neutron activation analysis involve
special aspects which may bear effect on the detection limits of different
elements as well as on the precision and accuracy of the analysis.Multielement
analyses of human cataractous lenses, of lenses with pseudo-exfoliation, of
human cerebrospinal fluid as well as of tissue samples of rats after the rats
exposure to stainless steel manual metal arc welding fumes have been carried
out.Se, Cr, Ni, Sc, Rb, Fe, Zn and Co could be detected in human lenses, Na,
K, Cl, Fe, Co, Zn, Se, Rb and Ag in human cerebrospinal fluid and Cr, Ni, Fe,
Zn, Se, Rb and Co in organ samples of rats.The differences of element
concentrations both in cataractous lenses as well as in pseudo-exfoliative
lenses are looked into.In the application of activation analysis to the study
of cerebrospinal fluid the principal emphasis was laid on the risk of
contamination during sampling and the problems when analyzing small amounts of
samples with low element concentrations.The retention kinetics of Cr, Ni and
magnetic Fe into different organs of exposed rats yield knowledge on the
welding of stainless steel as an occupational health problem.Neutron
activation analysis is a suitable multielement analytical method when the
samples are liable to be contaminated, when the sample size is small and
furthermore, when the element concentrations are low.However, the analysis of
biological samples of different kinds will call for special attention during
all stages of the analytical procedure so as to ensure the reliability of the
analytical results.
| Original language | English |
|---|---|
| Qualification | Doctor Degree |
| Awarding Institution |
|
| Award date | 16 Oct 1981 |
| Place of Publication | Espoo |
| Publisher | |
| Print ISBNs | 951-38-1306-1 |
| Publication status | Published - 1981 |
| MoE publication type | G5 Doctoral dissertation (article) |
