Neutron activation-based gamma scintigraphy in pharmacoscintigraphic evaluation of an Egalet® constant-release drug delivery system

Janne Marvola (Corresponding Author), Hanna Kanerva, Lillian Slot, Maija Lipponen, Tommi Kekki, Heikki Hietanen, Sirpa Mykkänen, Kari Ariniemi, Kai Lindevall, Martti Marvola

    Research output: Contribution to journalArticleScientificpeer-review

    18 Citations (Scopus)

    Abstract

    This paper is a report from a pharmacoscintigraphic study with an Egalet® constant-release system containing caffeine and natural abundance samarium oxide. First the formulation was tested in vitro to clarify integrity during irradiation in the nuclear reactor. Then six healthy male volunteers were enrolled into the in vivo study. The in vitro release of caffeine obeyed all the time linear zero-order kinetics. The in vivo release of radioactive Sm2O3 consisted of three consequent linear phases with different slopes. The release rate was fastest while the product was in the small intestine and slowest when the product was in the descending colon. In terms of the bioavailability of caffeine, the most important factor seemed to be the residence time in the ascending and transverse colon. A long residence time in these sections led to high AUC values for caffeine.
    Original languageEnglish
    Pages (from-to)3 - 10
    Number of pages8
    JournalInternational Journal of Pharmaceutics
    Volume281
    Issue number1-2
    DOIs
    Publication statusPublished - 2004
    MoE publication typeA1 Journal article-refereed

    Fingerprint

    Neutrons
    Drug Delivery Systems
    Caffeine
    Radionuclide Imaging
    Nuclear Reactors
    Descending Colon
    Ascending Colon
    Transverse Colon
    Biological Availability
    Small Intestine
    Area Under Curve
    Healthy Volunteers
    In Vitro Techniques
    samarium oxide

    Keywords

    • gamma scintigraphy
    • neutron activation
    • samarium
    • imaging
    • controlled release
    • in vitro-in vivo correlation

    Cite this

    Marvola, Janne ; Kanerva, Hanna ; Slot, Lillian ; Lipponen, Maija ; Kekki, Tommi ; Hietanen, Heikki ; Mykkänen, Sirpa ; Ariniemi, Kari ; Lindevall, Kai ; Marvola, Martti. / Neutron activation-based gamma scintigraphy in pharmacoscintigraphic evaluation of an Egalet® constant-release drug delivery system. In: International Journal of Pharmaceutics. 2004 ; Vol. 281, No. 1-2. pp. 3 - 10.
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    abstract = "This paper is a report from a pharmacoscintigraphic study with an Egalet{\circledR} constant-release system containing caffeine and natural abundance samarium oxide. First the formulation was tested in vitro to clarify integrity during irradiation in the nuclear reactor. Then six healthy male volunteers were enrolled into the in vivo study. The in vitro release of caffeine obeyed all the time linear zero-order kinetics. The in vivo release of radioactive Sm2O3 consisted of three consequent linear phases with different slopes. The release rate was fastest while the product was in the small intestine and slowest when the product was in the descending colon. In terms of the bioavailability of caffeine, the most important factor seemed to be the residence time in the ascending and transverse colon. A long residence time in these sections led to high AUC values for caffeine.",
    keywords = "gamma scintigraphy, neutron activation, samarium, imaging, controlled release, in vitro-in vivo correlation",
    author = "Janne Marvola and Hanna Kanerva and Lillian Slot and Maija Lipponen and Tommi Kekki and Heikki Hietanen and Sirpa Mykk{\"a}nen and Kari Ariniemi and Kai Lindevall and Martti Marvola",
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    Marvola, J, Kanerva, H, Slot, L, Lipponen, M, Kekki, T, Hietanen, H, Mykkänen, S, Ariniemi, K, Lindevall, K & Marvola, M 2004, 'Neutron activation-based gamma scintigraphy in pharmacoscintigraphic evaluation of an Egalet® constant-release drug delivery system', International Journal of Pharmaceutics, vol. 281, no. 1-2, pp. 3 - 10. https://doi.org/10.1016/j.ijpharm.2004.05.022

    Neutron activation-based gamma scintigraphy in pharmacoscintigraphic evaluation of an Egalet® constant-release drug delivery system. / Marvola, Janne (Corresponding Author); Kanerva, Hanna; Slot, Lillian; Lipponen, Maija; Kekki, Tommi; Hietanen, Heikki; Mykkänen, Sirpa; Ariniemi, Kari; Lindevall, Kai; Marvola, Martti.

    In: International Journal of Pharmaceutics, Vol. 281, No. 1-2, 2004, p. 3 - 10.

    Research output: Contribution to journalArticleScientificpeer-review

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    T1 - Neutron activation-based gamma scintigraphy in pharmacoscintigraphic evaluation of an Egalet® constant-release drug delivery system

    AU - Marvola, Janne

    AU - Kanerva, Hanna

    AU - Slot, Lillian

    AU - Lipponen, Maija

    AU - Kekki, Tommi

    AU - Hietanen, Heikki

    AU - Mykkänen, Sirpa

    AU - Ariniemi, Kari

    AU - Lindevall, Kai

    AU - Marvola, Martti

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    AB - This paper is a report from a pharmacoscintigraphic study with an Egalet® constant-release system containing caffeine and natural abundance samarium oxide. First the formulation was tested in vitro to clarify integrity during irradiation in the nuclear reactor. Then six healthy male volunteers were enrolled into the in vivo study. The in vitro release of caffeine obeyed all the time linear zero-order kinetics. The in vivo release of radioactive Sm2O3 consisted of three consequent linear phases with different slopes. The release rate was fastest while the product was in the small intestine and slowest when the product was in the descending colon. In terms of the bioavailability of caffeine, the most important factor seemed to be the residence time in the ascending and transverse colon. A long residence time in these sections led to high AUC values for caffeine.

    KW - gamma scintigraphy

    KW - neutron activation

    KW - samarium

    KW - imaging

    KW - controlled release

    KW - in vitro-in vivo correlation

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