Neutron activation-based gamma scintigraphy in pharmacoscintigraphic evaluation of an Egalet® constant-release drug delivery system

Janne Marvola (Corresponding Author), Hanna Kanerva, Lillian Slot, Maija Lipponen, Tommi Kekki, Heikki Hietanen, Sirpa Mykkänen, Kari Ariniemi, Kai Lindevall, Martti Marvola

Research output: Contribution to journalArticleScientificpeer-review

18 Citations (Scopus)

Abstract

This paper is a report from a pharmacoscintigraphic study with an Egalet® constant-release system containing caffeine and natural abundance samarium oxide. First the formulation was tested in vitro to clarify integrity during irradiation in the nuclear reactor. Then six healthy male volunteers were enrolled into the in vivo study. The in vitro release of caffeine obeyed all the time linear zero-order kinetics. The in vivo release of radioactive Sm2O3 consisted of three consequent linear phases with different slopes. The release rate was fastest while the product was in the small intestine and slowest when the product was in the descending colon. In terms of the bioavailability of caffeine, the most important factor seemed to be the residence time in the ascending and transverse colon. A long residence time in these sections led to high AUC values for caffeine.
Original languageEnglish
Pages (from-to)3 - 10
Number of pages8
JournalInternational Journal of Pharmaceutics
Volume281
Issue number1-2
DOIs
Publication statusPublished - 2004
MoE publication typeA1 Journal article-refereed

Fingerprint

Neutrons
Drug Delivery Systems
Caffeine
Radionuclide Imaging
Nuclear Reactors
Descending Colon
Ascending Colon
Transverse Colon
Biological Availability
Small Intestine
Area Under Curve
Healthy Volunteers
In Vitro Techniques
samarium oxide

Keywords

  • gamma scintigraphy
  • neutron activation
  • samarium
  • imaging
  • controlled release
  • in vitro-in vivo correlation

Cite this

Marvola, Janne ; Kanerva, Hanna ; Slot, Lillian ; Lipponen, Maija ; Kekki, Tommi ; Hietanen, Heikki ; Mykkänen, Sirpa ; Ariniemi, Kari ; Lindevall, Kai ; Marvola, Martti. / Neutron activation-based gamma scintigraphy in pharmacoscintigraphic evaluation of an Egalet® constant-release drug delivery system. In: International Journal of Pharmaceutics. 2004 ; Vol. 281, No. 1-2. pp. 3 - 10.
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abstract = "This paper is a report from a pharmacoscintigraphic study with an Egalet{\circledR} constant-release system containing caffeine and natural abundance samarium oxide. First the formulation was tested in vitro to clarify integrity during irradiation in the nuclear reactor. Then six healthy male volunteers were enrolled into the in vivo study. The in vitro release of caffeine obeyed all the time linear zero-order kinetics. The in vivo release of radioactive Sm2O3 consisted of three consequent linear phases with different slopes. The release rate was fastest while the product was in the small intestine and slowest when the product was in the descending colon. In terms of the bioavailability of caffeine, the most important factor seemed to be the residence time in the ascending and transverse colon. A long residence time in these sections led to high AUC values for caffeine.",
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author = "Janne Marvola and Hanna Kanerva and Lillian Slot and Maija Lipponen and Tommi Kekki and Heikki Hietanen and Sirpa Mykk{\"a}nen and Kari Ariniemi and Kai Lindevall and Martti Marvola",
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Marvola, J, Kanerva, H, Slot, L, Lipponen, M, Kekki, T, Hietanen, H, Mykkänen, S, Ariniemi, K, Lindevall, K & Marvola, M 2004, 'Neutron activation-based gamma scintigraphy in pharmacoscintigraphic evaluation of an Egalet® constant-release drug delivery system', International Journal of Pharmaceutics, vol. 281, no. 1-2, pp. 3 - 10. https://doi.org/10.1016/j.ijpharm.2004.05.022

Neutron activation-based gamma scintigraphy in pharmacoscintigraphic evaluation of an Egalet® constant-release drug delivery system. / Marvola, Janne (Corresponding Author); Kanerva, Hanna; Slot, Lillian; Lipponen, Maija; Kekki, Tommi; Hietanen, Heikki; Mykkänen, Sirpa; Ariniemi, Kari; Lindevall, Kai; Marvola, Martti.

In: International Journal of Pharmaceutics, Vol. 281, No. 1-2, 2004, p. 3 - 10.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Neutron activation-based gamma scintigraphy in pharmacoscintigraphic evaluation of an Egalet® constant-release drug delivery system

AU - Marvola, Janne

AU - Kanerva, Hanna

AU - Slot, Lillian

AU - Lipponen, Maija

AU - Kekki, Tommi

AU - Hietanen, Heikki

AU - Mykkänen, Sirpa

AU - Ariniemi, Kari

AU - Lindevall, Kai

AU - Marvola, Martti

PY - 2004

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N2 - This paper is a report from a pharmacoscintigraphic study with an Egalet® constant-release system containing caffeine and natural abundance samarium oxide. First the formulation was tested in vitro to clarify integrity during irradiation in the nuclear reactor. Then six healthy male volunteers were enrolled into the in vivo study. The in vitro release of caffeine obeyed all the time linear zero-order kinetics. The in vivo release of radioactive Sm2O3 consisted of three consequent linear phases with different slopes. The release rate was fastest while the product was in the small intestine and slowest when the product was in the descending colon. In terms of the bioavailability of caffeine, the most important factor seemed to be the residence time in the ascending and transverse colon. A long residence time in these sections led to high AUC values for caffeine.

AB - This paper is a report from a pharmacoscintigraphic study with an Egalet® constant-release system containing caffeine and natural abundance samarium oxide. First the formulation was tested in vitro to clarify integrity during irradiation in the nuclear reactor. Then six healthy male volunteers were enrolled into the in vivo study. The in vitro release of caffeine obeyed all the time linear zero-order kinetics. The in vivo release of radioactive Sm2O3 consisted of three consequent linear phases with different slopes. The release rate was fastest while the product was in the small intestine and slowest when the product was in the descending colon. In terms of the bioavailability of caffeine, the most important factor seemed to be the residence time in the ascending and transverse colon. A long residence time in these sections led to high AUC values for caffeine.

KW - gamma scintigraphy

KW - neutron activation

KW - samarium

KW - imaging

KW - controlled release

KW - in vitro-in vivo correlation

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JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

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