Newly isolated sporopollenin microcages from Platanus orientalis pollens as a vehicle for controlled drug delivery

Muhammad Mujtaba; Idris Sargin; Lalehan Akyuz; Talip Ceter; Murat Kaya

doi:10.1016/j.msec.2017.02.176

Newly isolated sporopollenin microcages from Platanus orientalis pollens as a vehicle for controlled drug delivery

Muhammad Mujtaba, Idris Sargin, Lalehan Akyuz, Talip Ceter, Murat Kaya (Corresponding Author)

Not published at VTT

Research output: Contribution to journal › Article › Scientific › peer-review

23 Citations (Scopus)

Abstract

Sporopollenin microcages were produced from the pollens of Platanus orientalis. Paracetamol was loaded into the microcages. Pollen, sporopollenin, paracetamol and paracetamol-loaded sporopollenin microcages were characterized with FT-IR, TGA and SEM. The analytical analyses demonstrated that sporopollenin microcages were structurally intact, highly reticulated and thermally stable. The loading efficiency of the sporopollenin microcages was found to be 8.2% using the passive loading technique and 23.7% via evaporating loading technique. In vitro release and kinetics studies were performed to test the suitability of sporopollenin microcages for loading. These studies revealed that sporopollenin from P. orientalis can be suggested as a suitable carrier for drug loading and controlled release studies.

Original language	English
Pages (from-to)	263-270
Number of pages	8
Journal	Materials Science and Engineering C: Biomimetic and Supramolecular Systems
Volume	77
DOIs	https://doi.org/10.1016/j.msec.2017.02.176
Publication status	Published - 1 Aug 2017
MoE publication type	A1 Journal article-refereed

Keywords

Acetaminophen
Drug delivery
Microcapsule
Release kinetics

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10.1016/j.msec.2017.02.176

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title = "Newly isolated sporopollenin microcages from Platanus orientalis pollens as a vehicle for controlled drug delivery",

abstract = "Sporopollenin microcages were produced from the pollens of Platanus orientalis. Paracetamol was loaded into the microcages. Pollen, sporopollenin, paracetamol and paracetamol-loaded sporopollenin microcages were characterized with FT-IR, TGA and SEM. The analytical analyses demonstrated that sporopollenin microcages were structurally intact, highly reticulated and thermally stable. The loading efficiency of the sporopollenin microcages was found to be 8.2% using the passive loading technique and 23.7% via evaporating loading technique. In vitro release and kinetics studies were performed to test the suitability of sporopollenin microcages for loading. These studies revealed that sporopollenin from P. orientalis can be suggested as a suitable carrier for drug loading and controlled release studies.",

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AU - Mujtaba, Muhammad

AU - Sargin, Idris

AU - Akyuz, Lalehan

AU - Ceter, Talip

AU - Kaya, Murat

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Sporopollenin microcages were produced from the pollens of Platanus orientalis. Paracetamol was loaded into the microcages. Pollen, sporopollenin, paracetamol and paracetamol-loaded sporopollenin microcages were characterized with FT-IR, TGA and SEM. The analytical analyses demonstrated that sporopollenin microcages were structurally intact, highly reticulated and thermally stable. The loading efficiency of the sporopollenin microcages was found to be 8.2% using the passive loading technique and 23.7% via evaporating loading technique. In vitro release and kinetics studies were performed to test the suitability of sporopollenin microcages for loading. These studies revealed that sporopollenin from P. orientalis can be suggested as a suitable carrier for drug loading and controlled release studies.

AB - Sporopollenin microcages were produced from the pollens of Platanus orientalis. Paracetamol was loaded into the microcages. Pollen, sporopollenin, paracetamol and paracetamol-loaded sporopollenin microcages were characterized with FT-IR, TGA and SEM. The analytical analyses demonstrated that sporopollenin microcages were structurally intact, highly reticulated and thermally stable. The loading efficiency of the sporopollenin microcages was found to be 8.2% using the passive loading technique and 23.7% via evaporating loading technique. In vitro release and kinetics studies were performed to test the suitability of sporopollenin microcages for loading. These studies revealed that sporopollenin from P. orientalis can be suggested as a suitable carrier for drug loading and controlled release studies.

KW - Acetaminophen

KW - Drug delivery

KW - Microcapsule

KW - Release kinetics

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ER -

Newly isolated sporopollenin microcages from Platanus orientalis pollens as a vehicle for controlled drug delivery

Abstract

Keywords

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