Non-invasive glucose sensing in scattering media using OCT, PAS and TOP techniques

Erkki Alarousu, Jukka Hast, Matti Kinnunen, Mikhail Kirillin, Risto Myllylä, Jerzy Plucinski, Alexey Popov, Alexander Priezzhev, Tuukka Prykäri, Juha Saarela, Zhao Zuomin

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

19 Citations (Scopus)

Abstract

In this paper, optical measurement techniques, which enable non-invasive measurement, are superimposed to glucose sensing in scattering media. Used measurement techniques are Optical Coherence Tomography (OCT), Photoacoustic spectroscopy (PAS) and laser pulse Time-of-Flight (TOF) measurement using a streak camera. In parallel with measurements, a Monte-Carlo (MC) simulation models have been developed. Experimental in vitro measurements were performed using Intralipid™ fat emulsion as a tissue simulating phantom for OCT and TOF measurements. In PAS measurements, a pork meat was used as a subject but also preliminary in vivo measurements were done. OCT measurement results show that the slope of the OCT signal's envelope changes as a function of glucose content in the scattering media. TOF measurements show that the laser pulse full width of half maximum (FWHM) changes a little as function of glucose content. An agreement with MC-simulations and measurements with Intralipid™ was also found. Measurement results of PAS technique show that changes in glucose content in the pork meat tissue can be measured. In vivo measurements with a human volunteer show that other factors such as physiological change, blood circulation and body temperature drift may interfere the PA response of glucose.

Original languageEnglish
Title of host publicationSaratov Fall Meeting 2003
Subtitle of host publicationOptical Technologies in Biophysics and Medicine V
EditorsValery V. Tuchin
PublisherInternational Society for Optics and Photonics SPIE
Pages33-41
ISBN (Print)978-0-8194-5397-6
DOIs
Publication statusPublished - 1 Dec 2004
MoE publication typeA4 Article in a conference publication
EventSaratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V - Saratov, Russian Federation
Duration: 7 Oct 200310 Oct 2003

Publication series

SeriesProgress in Biomedical Optics and Imaging
Number29
Volume5
ISSN1605-7422
SeriesProceedings of SPIE
Volume5474
ISSN0277-786X

Workshop

WorkshopSaratov Fall Meeting 2003
CountryRussian Federation
CitySaratov
Period7/10/0310/10/03

Keywords

  • Glucose sensing
  • OCT
  • PAS
  • Scattering media
  • TOF

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