Non-invasive glucose sensing in scattering media using OCT, PAS and TOP techniques

Erkki Alarousu; Jukka Hast; Matti Kinnunen; Mikhail Kirillin; Risto Myllylä; Jerzy Plucinski; Alexey Popov; Alexander Priezzhev; Tuukka Prykäri; Juha Saarela; Zhao Zuomin

doi:10.1117/12.578321

Non-invasive glucose sensing in scattering media using OCT, PAS and TOP techniques

Erkki Alarousu, Jukka Hast, Matti Kinnunen, Mikhail Kirillin, Risto Myllylä, Jerzy Plucinski, Alexey Popov, Alexander Priezzhev, Tuukka Prykäri, Juha Saarela, Zhao Zuomin

Not published at VTT

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceedings › Scientific › peer-review

23 Citations (Scopus)

Abstract

In this paper, optical measurement techniques, which enable non-invasive measurement, are superimposed to glucose sensing in scattering media. Used measurement techniques are Optical Coherence Tomography (OCT), Photoacoustic spectroscopy (PAS) and laser pulse Time-of-Flight (TOF) measurement using a streak camera. In parallel with measurements, a Monte-Carlo (MC) simulation models have been developed. Experimental in vitro measurements were performed using Intralipid™ fat emulsion as a tissue simulating phantom for OCT and TOF measurements. In PAS measurements, a pork meat was used as a subject but also preliminary in vivo measurements were done. OCT measurement results show that the slope of the OCT signal's envelope changes as a function of glucose content in the scattering media. TOF measurements show that the laser pulse full width of half maximum (FWHM) changes a little as function of glucose content. An agreement with MC-simulations and measurements with Intralipid™ was also found. Measurement results of PAS technique show that changes in glucose content in the pork meat tissue can be measured. In vivo measurements with a human volunteer show that other factors such as physiological change, blood circulation and body temperature drift may interfere the PA response of glucose.

Original language	English
Title of host publication	Saratov Fall Meeting 2003
Subtitle of host publication	Optical Technologies in Biophysics and Medicine V
Editors	Valery V. Tuchin
Publisher	International Society for Optics and Photonics SPIE
Pages	33-41
ISBN (Print)	978-0-8194-5397-6
DOIs	https://doi.org/10.1117/12.578321
Publication status	Published - 1 Dec 2004
MoE publication type	A4 Article in a conference publication
Event	Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V - Saratov, Russian Federation Duration: 7 Oct 2003 → 10 Oct 2003

Publication series

Series	Progress in Biomedical Optics and Imaging
Number	29
Volume	5
ISSN	1605-7422

Series	Proceedings of SPIE
Volume	5474
ISSN	0277-786X

Workshop

Workshop	Saratov Fall Meeting 2003
Country/Territory	Russian Federation
City	Saratov
Period	7/10/03 → 10/10/03

Keywords

Glucose sensing
OCT
PAS
Scattering media
TOF

Access to Document

10.1117/12.578321

Cite this

Alarousu, E., Hast, J., Kinnunen, M., Kirillin, M., Myllylä, R., Plucinski, J., Popov, A., Priezzhev, A., Prykäri, T., Saarela, J., & Zuomin, Z. (2004). Non-invasive glucose sensing in scattering media using OCT, PAS and TOP techniques. In V. V. Tuchin (Ed.), Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V (pp. 33-41). International Society for Optics and Photonics SPIE. Progress in Biomedical Optics and Imaging Vol. 5 No. 29Proceedings of SPIE Vol. 5474 https://doi.org/10.1117/12.578321

Alarousu, Erkki ; Hast, Jukka ; Kinnunen, Matti et al. / Non-invasive glucose sensing in scattering media using OCT, PAS and TOP techniques. Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V. editor / Valery V. Tuchin. International Society for Optics and Photonics SPIE, 2004. pp. 33-41 (Progress in Biomedical Optics and Imaging; No. 29, Vol. 5). (Proceedings of SPIE, Vol. 5474).

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title = "Non-invasive glucose sensing in scattering media using OCT, PAS and TOP techniques",

abstract = "In this paper, optical measurement techniques, which enable non-invasive measurement, are superimposed to glucose sensing in scattering media. Used measurement techniques are Optical Coherence Tomography (OCT), Photoacoustic spectroscopy (PAS) and laser pulse Time-of-Flight (TOF) measurement using a streak camera. In parallel with measurements, a Monte-Carlo (MC) simulation models have been developed. Experimental in vitro measurements were performed using Intralipid{\texttrademark} fat emulsion as a tissue simulating phantom for OCT and TOF measurements. In PAS measurements, a pork meat was used as a subject but also preliminary in vivo measurements were done. OCT measurement results show that the slope of the OCT signal's envelope changes as a function of glucose content in the scattering media. TOF measurements show that the laser pulse full width of half maximum (FWHM) changes a little as function of glucose content. An agreement with MC-simulations and measurements with Intralipid{\texttrademark} was also found. Measurement results of PAS technique show that changes in glucose content in the pork meat tissue can be measured. In vivo measurements with a human volunteer show that other factors such as physiological change, blood circulation and body temperature drift may interfere the PA response of glucose.",

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author = "Erkki Alarousu and Jukka Hast and Matti Kinnunen and Mikhail Kirillin and Risto Myllyl{\"a} and Jerzy Plucinski and Alexey Popov and Alexander Priezzhev and Tuukka Pryk{\"a}ri and Juha Saarela and Zhao Zuomin",

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Alarousu, E, Hast, J, Kinnunen, M, Kirillin, M, Myllylä, R, Plucinski, J, Popov, A, Priezzhev, A, Prykäri, T, Saarela, J & Zuomin, Z 2004, Non-invasive glucose sensing in scattering media using OCT, PAS and TOP techniques. in VV Tuchin (ed.), Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V. International Society for Optics and Photonics SPIE, Progress in Biomedical Optics and Imaging, no. 29, vol. 5, Proceedings of SPIE, vol. 5474, pp. 33-41, Saratov Fall Meeting 2003, Saratov, Russian Federation, 7/10/03. https://doi.org/10.1117/12.578321

Non-invasive glucose sensing in scattering media using OCT, PAS and TOP techniques. / Alarousu, Erkki; Hast, Jukka; Kinnunen, Matti et al.

Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V. ed. / Valery V. Tuchin. International Society for Optics and Photonics SPIE, 2004. p. 33-41 (Progress in Biomedical Optics and Imaging; No. 29, Vol. 5). (Proceedings of SPIE, Vol. 5474).

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceedings › Scientific › peer-review

TY - GEN

T1 - Non-invasive glucose sensing in scattering media using OCT, PAS and TOP techniques

AU - Alarousu, Erkki

AU - Hast, Jukka

AU - Kinnunen, Matti

AU - Kirillin, Mikhail

AU - Myllylä, Risto

AU - Plucinski, Jerzy

AU - Popov, Alexey

AU - Priezzhev, Alexander

AU - Prykäri, Tuukka

AU - Saarela, Juha

AU - Zuomin, Zhao

PY - 2004/12/1

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N2 - In this paper, optical measurement techniques, which enable non-invasive measurement, are superimposed to glucose sensing in scattering media. Used measurement techniques are Optical Coherence Tomography (OCT), Photoacoustic spectroscopy (PAS) and laser pulse Time-of-Flight (TOF) measurement using a streak camera. In parallel with measurements, a Monte-Carlo (MC) simulation models have been developed. Experimental in vitro measurements were performed using Intralipid™ fat emulsion as a tissue simulating phantom for OCT and TOF measurements. In PAS measurements, a pork meat was used as a subject but also preliminary in vivo measurements were done. OCT measurement results show that the slope of the OCT signal's envelope changes as a function of glucose content in the scattering media. TOF measurements show that the laser pulse full width of half maximum (FWHM) changes a little as function of glucose content. An agreement with MC-simulations and measurements with Intralipid™ was also found. Measurement results of PAS technique show that changes in glucose content in the pork meat tissue can be measured. In vivo measurements with a human volunteer show that other factors such as physiological change, blood circulation and body temperature drift may interfere the PA response of glucose.

AB - In this paper, optical measurement techniques, which enable non-invasive measurement, are superimposed to glucose sensing in scattering media. Used measurement techniques are Optical Coherence Tomography (OCT), Photoacoustic spectroscopy (PAS) and laser pulse Time-of-Flight (TOF) measurement using a streak camera. In parallel with measurements, a Monte-Carlo (MC) simulation models have been developed. Experimental in vitro measurements were performed using Intralipid™ fat emulsion as a tissue simulating phantom for OCT and TOF measurements. In PAS measurements, a pork meat was used as a subject but also preliminary in vivo measurements were done. OCT measurement results show that the slope of the OCT signal's envelope changes as a function of glucose content in the scattering media. TOF measurements show that the laser pulse full width of half maximum (FWHM) changes a little as function of glucose content. An agreement with MC-simulations and measurements with Intralipid™ was also found. Measurement results of PAS technique show that changes in glucose content in the pork meat tissue can be measured. In vivo measurements with a human volunteer show that other factors such as physiological change, blood circulation and body temperature drift may interfere the PA response of glucose.

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KW - PAS

KW - Scattering media

KW - TOF

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Alarousu E, Hast J, Kinnunen M, Kirillin M, Myllylä R, Plucinski J et al. Non-invasive glucose sensing in scattering media using OCT, PAS and TOP techniques. In Tuchin VV, editor, Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V. International Society for Optics and Photonics SPIE. 2004. p. 33-41. (Progress in Biomedical Optics and Imaging; No. 29, Vol. 5). (Proceedings of SPIE, Vol. 5474). doi: 10.1117/12.578321

Non-invasive glucose sensing in scattering media using OCT, PAS and TOP techniques

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Keywords

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