Noninvasive control of rhodamine-loaded capsules distribution in vivo

O. Stelmashchuk, Y. Tarakanchikova, E. Seryogina, G. Piavchenko, E. Zherebtsov, A. Dunaev, Alexey Popov, I. Meglinski

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

Abstract

Using fluorescence spectroscopy system with fibre-optical probe, we investigated the dynamics of propagation and circulation in the microcirculatory system of experimental nanocapsules fluorescent-labelled (rhodamine TRITC) nanocapsules. The studies were carried out in clinically healthy Wistar rats. The model animals were divided into control group and group received injections of the nanocapsules. The fluorescent measurements conducted transcutaneously on the thigh surface. The administration of the preparation with the rhodamine concentration of 5 mg/kg of animal weight resulted in twofold increase of fluorescence intensity by reference to the baseline level. As a result of the study, it was concluded that fluorescence spectroscopy can be used for transdermal measurements of the rhodamine-loaded capsules in vivo.

Original languageEnglish
Title of host publicationSaratov Fall Meeting 2017
Subtitle of host publicationOptical Technologies in Biophysics and Medicine XIX
EditorsElina A. Genina, Irina Yu. Goryacheva, Valery V. Tuchin
PublisherInternational Society for Optics and Photonics SPIE
ISBN (Electronic)978-1-51062-002-5
ISBN (Print)978-1-51062-001-8
DOIs
Publication statusPublished - 26 Apr 2018
MoE publication typeNot Eligible
EventSaratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX - Saratov, Russian Federation
Duration: 26 Sep 201730 Sep 2017

Publication series

SeriesProgress in Biomedical Optics and Imaging
Number56
Volume19
ISSN1605-7422
SeriesProceedings of SPIE
Volume10716
ISSN0277-786X

Conference

ConferenceSaratov Fall Meeting 2017
CountryRussian Federation
CitySaratov
Period26/09/1730/09/17

Keywords

  • blood microcirculation
  • drug delivery
  • fluorescence spectroscopy
  • fluorescent labelled particles
  • nanocomposite polymeric capsules
  • optical measurements in vivo
  • rhodamine TRITC

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