Noninvasive control of rhodamine-loaded capsules distribution in vivo

O. Stelmashchuk; Y. Tarakanchikova; E. Seryogina; G. Piavchenko; E. Zherebtsov; A. Dunaev; Alexey Popov; I. Meglinski

doi:10.1117/12.2315773

Noninvasive control of rhodamine-loaded capsules distribution in vivo

O. Stelmashchuk, Y. Tarakanchikova, E. Seryogina, G. Piavchenko, E. Zherebtsov, A. Dunaev, Alexey Popov, I. Meglinski

Not published at VTT

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceedings › Scientific › peer-review

Abstract

Using fluorescence spectroscopy system with fibre-optical probe, we investigated the dynamics of propagation and circulation in the microcirculatory system of experimental nanocapsules fluorescent-labelled (rhodamine TRITC) nanocapsules. The studies were carried out in clinically healthy Wistar rats. The model animals were divided into control group and group received injections of the nanocapsules. The fluorescent measurements conducted transcutaneously on the thigh surface. The administration of the preparation with the rhodamine concentration of 5 mg/kg of animal weight resulted in twofold increase of fluorescence intensity by reference to the baseline level. As a result of the study, it was concluded that fluorescence spectroscopy can be used for transdermal measurements of the rhodamine-loaded capsules in vivo.

Original language	English
Title of host publication	Saratov Fall Meeting 2017
Subtitle of host publication	Optical Technologies in Biophysics and Medicine XIX
Editors	Elina A. Genina, Irina Yu. Goryacheva, Valery V. Tuchin
Publisher	International Society for Optics and Photonics SPIE
ISBN (Electronic)	978-1-51062-002-5
ISBN (Print)	978-1-51062-001-8
DOIs	https://doi.org/10.1117/12.2315773
Publication status	Published - 26 Apr 2018
MoE publication type	Not Eligible
Event	Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX - Saratov, Russian Federation Duration: 26 Sept 2017 → 30 Sept 2017

Publication series

Series	Progress in Biomedical Optics and Imaging
Number	56
Volume	19
ISSN	1605-7422

Series	Proceedings of SPIE
Volume	10716
ISSN	0277-786X

Conference

Conference	Saratov Fall Meeting 2017
Country/Territory	Russian Federation
City	Saratov
Period	26/09/17 → 30/09/17

Funding

This work was supported by the Russian Foundation on Innovations U.M.N.I.K., 2017 SPIE Optics and Photonics Education Scholarship, CIMO Fellowship (TM-15-9729, YT), EDUFI Fellowship (TM-17-10389, YT), Russian Government (grant No. 074-U01, AP, IM), Russian Science Foundation (grant No. 15-14-10008, IM), MEPhI Academic Excellence Project (Contract No. 02.a03.21.0005, IM), Academy of Finland (grant No. 290596, AP). EZ kindly acknowledges the funding from the European Union’s Horizon 2020 Research and Innovation Program under grant agreement No. 703145.

Keywords

blood microcirculation
drug delivery
fluorescence spectroscopy
fluorescent labelled particles
nanocomposite polymeric capsules
optical measurements in vivo
rhodamine TRITC

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10.1117/12.2315773

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Stelmashchuk, O., Tarakanchikova, Y., Seryogina, E., Piavchenko, G., Zherebtsov, E., Dunaev, A., Popov, A., & Meglinski, I. (2018). Noninvasive control of rhodamine-loaded capsules distribution in vivo. In E. A. Genina, I. Y. Goryacheva, & V. V. Tuchin (Eds.), Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX Article 1071619 International Society for Optics and Photonics SPIE. https://doi.org/10.1117/12.2315773

Stelmashchuk, O. ; Tarakanchikova, Y. ; Seryogina, E. et al. / Noninvasive control of rhodamine-loaded capsules distribution in vivo. Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX. editor / Elina A. Genina ; Irina Yu. Goryacheva ; Valery V. Tuchin. International Society for Optics and Photonics SPIE, 2018. (Progress in Biomedical Optics and Imaging; No. 56, Vol. 19). (Proceedings of SPIE, Vol. 10716).

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title = "Noninvasive control of rhodamine-loaded capsules distribution in vivo",

abstract = "Using fluorescence spectroscopy system with fibre-optical probe, we investigated the dynamics of propagation and circulation in the microcirculatory system of experimental nanocapsules fluorescent-labelled (rhodamine TRITC) nanocapsules. The studies were carried out in clinically healthy Wistar rats. The model animals were divided into control group and group received injections of the nanocapsules. The fluorescent measurements conducted transcutaneously on the thigh surface. The administration of the preparation with the rhodamine concentration of 5 mg/kg of animal weight resulted in twofold increase of fluorescence intensity by reference to the baseline level. As a result of the study, it was concluded that fluorescence spectroscopy can be used for transdermal measurements of the rhodamine-loaded capsules in vivo.",

keywords = "blood microcirculation, drug delivery, fluorescence spectroscopy, fluorescent labelled particles, nanocomposite polymeric capsules, optical measurements in vivo, rhodamine TRITC",

author = "O. Stelmashchuk and Y. Tarakanchikova and E. Seryogina and G. Piavchenko and E. Zherebtsov and A. Dunaev and Alexey Popov and I. Meglinski",

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Stelmashchuk, O, Tarakanchikova, Y, Seryogina, E, Piavchenko, G, Zherebtsov, E, Dunaev, A, Popov, A & Meglinski, I 2018, Noninvasive control of rhodamine-loaded capsules distribution in vivo. in EA Genina, IY Goryacheva & VV Tuchin (eds), Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX., 1071619, International Society for Optics and Photonics SPIE, Progress in Biomedical Optics and Imaging, no. 56, vol. 19, Proceedings of SPIE, vol. 10716, Saratov Fall Meeting 2017, Saratov, Russian Federation, 26/09/17. https://doi.org/10.1117/12.2315773

Noninvasive control of rhodamine-loaded capsules distribution in vivo. / Stelmashchuk, O.; Tarakanchikova, Y.; Seryogina, E. et al.
Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX. ed. / Elina A. Genina; Irina Yu. Goryacheva; Valery V. Tuchin. International Society for Optics and Photonics SPIE, 2018. 1071619 (Progress in Biomedical Optics and Imaging; No. 56, Vol. 19). (Proceedings of SPIE, Vol. 10716).

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceedings › Scientific › peer-review

TY - GEN

T1 - Noninvasive control of rhodamine-loaded capsules distribution in vivo

AU - Stelmashchuk, O.

AU - Tarakanchikova, Y.

AU - Seryogina, E.

AU - Piavchenko, G.

AU - Zherebtsov, E.

AU - Dunaev, A.

AU - Popov, Alexey

AU - Meglinski, I.

PY - 2018/4/26

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N2 - Using fluorescence spectroscopy system with fibre-optical probe, we investigated the dynamics of propagation and circulation in the microcirculatory system of experimental nanocapsules fluorescent-labelled (rhodamine TRITC) nanocapsules. The studies were carried out in clinically healthy Wistar rats. The model animals were divided into control group and group received injections of the nanocapsules. The fluorescent measurements conducted transcutaneously on the thigh surface. The administration of the preparation with the rhodamine concentration of 5 mg/kg of animal weight resulted in twofold increase of fluorescence intensity by reference to the baseline level. As a result of the study, it was concluded that fluorescence spectroscopy can be used for transdermal measurements of the rhodamine-loaded capsules in vivo.

AB - Using fluorescence spectroscopy system with fibre-optical probe, we investigated the dynamics of propagation and circulation in the microcirculatory system of experimental nanocapsules fluorescent-labelled (rhodamine TRITC) nanocapsules. The studies were carried out in clinically healthy Wistar rats. The model animals were divided into control group and group received injections of the nanocapsules. The fluorescent measurements conducted transcutaneously on the thigh surface. The administration of the preparation with the rhodamine concentration of 5 mg/kg of animal weight resulted in twofold increase of fluorescence intensity by reference to the baseline level. As a result of the study, it was concluded that fluorescence spectroscopy can be used for transdermal measurements of the rhodamine-loaded capsules in vivo.

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KW - drug delivery

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M3 - Conference article in proceedings

AN - SCOPUS:85047330610

SN - 978-1-51062-001-8

T3 - Progress in Biomedical Optics and Imaging

BT - Saratov Fall Meeting 2017

A2 - Genina, Elina A.

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Stelmashchuk O, Tarakanchikova Y, Seryogina E, Piavchenko G, Zherebtsov E, Dunaev A et al. Noninvasive control of rhodamine-loaded capsules distribution in vivo. In Genina EA, Goryacheva IY, Tuchin VV, editors, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX. International Society for Optics and Photonics SPIE. 2018. 1071619. (Progress in Biomedical Optics and Imaging; No. 56, Vol. 19). (Proceedings of SPIE, Vol. 10716). doi: 10.1117/12.2315773

Noninvasive control of rhodamine-loaded capsules distribution in vivo

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