Novel functions of vimentin in cell adhesion, migration, and signaling

Johanna Ivaska, Hanna-Mari Pallari, Jonna Nevo, John E. Eriksson

Research output: Contribution to journalArticleScientificpeer-review

477 Citations (Scopus)

Abstract

Vimentin is the major intermediate filament (IF) protein of mesenchymal cells. It shows dynamically altered expression patterns during different developmental stages and high sequence homology throughout all vertebrates, suggesting that the protein is physiologically important. Still, until recently, the real tasks of vimentin have been elusive, primarily because the vimentin-deficient mice were originally characterized as having a very mild phenotype.
Recent studies have revealed several key functions for vimentin that were not obvious at first sight. Vimentin emerges as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. The highly dynamic and complex phosphorylation of vimentin seems to be a likely regulator mechanism for these functions.
The implicated novel vimentin functions have broad ramifications into many different aspects of cell physiology, cellular interactions, and organ homeostasis.
Original languageEnglish
Pages (from-to)2050-2062
JournalExperimental Cell Research
Volume313
Issue number10
DOIs
Publication statusPublished - 2007
MoE publication typeA1 Journal article-refereed

Keywords

  • vimentin
  • intermediate filament
  • proteins
  • adhesion
  • signaling
  • kinase
  • phosphatase
  • phosphorylation
  • immune cells

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