Novel functions of vimentin in cell adhesion, migration, and signaling

Johanna Ivaska, Hanna-Mari Pallari, Jonna Nevo, John E. Eriksson

Research output: Contribution to journalArticleScientificpeer-review

429 Citations (Scopus)

Abstract

Vimentin is the major intermediate filament (IF) protein of mesenchymal cells. It shows dynamically altered expression patterns during different developmental stages and high sequence homology throughout all vertebrates, suggesting that the protein is physiologically important. Still, until recently, the real tasks of vimentin have been elusive, primarily because the vimentin-deficient mice were originally characterized as having a very mild phenotype.
Recent studies have revealed several key functions for vimentin that were not obvious at first sight. Vimentin emerges as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. The highly dynamic and complex phosphorylation of vimentin seems to be a likely regulator mechanism for these functions.
The implicated novel vimentin functions have broad ramifications into many different aspects of cell physiology, cellular interactions, and organ homeostasis.
Original languageEnglish
Pages (from-to)2050-2062
JournalExperimental Cell Research
Volume313
Issue number10
DOIs
Publication statusPublished - 2007
MoE publication typeA1 Journal article-refereed

Fingerprint

Vimentin
Cell Adhesion
Cell Movement
Intermediate Filament Proteins
Cell Physiological Phenomena
Sequence Homology
Vertebrates
Proteins
Homeostasis
Phosphorylation
Phenotype

Keywords

  • vimentin
  • intermediate filament
  • proteins
  • adhesion
  • signaling
  • kinase
  • phosphatase
  • phosphorylation
  • immune cells

Cite this

Ivaska, Johanna ; Pallari, Hanna-Mari ; Nevo, Jonna ; Eriksson, John E. / Novel functions of vimentin in cell adhesion, migration, and signaling. In: Experimental Cell Research. 2007 ; Vol. 313, No. 10. pp. 2050-2062.
@article{3da255e81d0d41c3bc5ffa2c7aa4c903,
title = "Novel functions of vimentin in cell adhesion, migration, and signaling",
abstract = "Vimentin is the major intermediate filament (IF) protein of mesenchymal cells. It shows dynamically altered expression patterns during different developmental stages and high sequence homology throughout all vertebrates, suggesting that the protein is physiologically important. Still, until recently, the real tasks of vimentin have been elusive, primarily because the vimentin-deficient mice were originally characterized as having a very mild phenotype. Recent studies have revealed several key functions for vimentin that were not obvious at first sight. Vimentin emerges as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. The highly dynamic and complex phosphorylation of vimentin seems to be a likely regulator mechanism for these functions. The implicated novel vimentin functions have broad ramifications into many different aspects of cell physiology, cellular interactions, and organ homeostasis.",
keywords = "vimentin, intermediate filament, proteins, adhesion, signaling, kinase, phosphatase, phosphorylation, immune cells",
author = "Johanna Ivaska and Hanna-Mari Pallari and Jonna Nevo and Eriksson, {John E.}",
year = "2007",
doi = "10.1016/j.yexcr.2007.03.040",
language = "English",
volume = "313",
pages = "2050--2062",
journal = "Experimental Cell Research",
issn = "0014-4827",
publisher = "Elsevier",
number = "10",

}

Ivaska, J, Pallari, H-M, Nevo, J & Eriksson, JE 2007, 'Novel functions of vimentin in cell adhesion, migration, and signaling', Experimental Cell Research, vol. 313, no. 10, pp. 2050-2062. https://doi.org/10.1016/j.yexcr.2007.03.040

Novel functions of vimentin in cell adhesion, migration, and signaling. / Ivaska, Johanna; Pallari, Hanna-Mari; Nevo, Jonna; Eriksson, John E.

In: Experimental Cell Research, Vol. 313, No. 10, 2007, p. 2050-2062.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Novel functions of vimentin in cell adhesion, migration, and signaling

AU - Ivaska, Johanna

AU - Pallari, Hanna-Mari

AU - Nevo, Jonna

AU - Eriksson, John E.

PY - 2007

Y1 - 2007

N2 - Vimentin is the major intermediate filament (IF) protein of mesenchymal cells. It shows dynamically altered expression patterns during different developmental stages and high sequence homology throughout all vertebrates, suggesting that the protein is physiologically important. Still, until recently, the real tasks of vimentin have been elusive, primarily because the vimentin-deficient mice were originally characterized as having a very mild phenotype. Recent studies have revealed several key functions for vimentin that were not obvious at first sight. Vimentin emerges as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. The highly dynamic and complex phosphorylation of vimentin seems to be a likely regulator mechanism for these functions. The implicated novel vimentin functions have broad ramifications into many different aspects of cell physiology, cellular interactions, and organ homeostasis.

AB - Vimentin is the major intermediate filament (IF) protein of mesenchymal cells. It shows dynamically altered expression patterns during different developmental stages and high sequence homology throughout all vertebrates, suggesting that the protein is physiologically important. Still, until recently, the real tasks of vimentin have been elusive, primarily because the vimentin-deficient mice were originally characterized as having a very mild phenotype. Recent studies have revealed several key functions for vimentin that were not obvious at first sight. Vimentin emerges as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. The highly dynamic and complex phosphorylation of vimentin seems to be a likely regulator mechanism for these functions. The implicated novel vimentin functions have broad ramifications into many different aspects of cell physiology, cellular interactions, and organ homeostasis.

KW - vimentin

KW - intermediate filament

KW - proteins

KW - adhesion

KW - signaling

KW - kinase

KW - phosphatase

KW - phosphorylation

KW - immune cells

U2 - 10.1016/j.yexcr.2007.03.040

DO - 10.1016/j.yexcr.2007.03.040

M3 - Article

VL - 313

SP - 2050

EP - 2062

JO - Experimental Cell Research

JF - Experimental Cell Research

SN - 0014-4827

IS - 10

ER -