Obesity and psychotic disorders: Uncovering common mechanisms through metabolomics

Matej Orešič

Research output: Contribution to journalReview Articlepeer-review

13 Citations (Scopus)

Abstract

Primary obesity and psychotic disorders are similar with respect to the associated changes in energy balance and co-morbidities, including metabolic syndrome. Such similarities do not necessarily demonstrate causal links, but instead suggest that specific causes of and metabolic disturbances associated with obesity play a pathogenic role in the development of co-morbid disorders, potentially even before obesity develops. Metabolomics – the systematic study of metabolites, which are small molecules generated by the process of metabolism – has been important in elucidating the pathways underlying obesity-associated co-morbidities. This review covers how recent metabolomic studies have advanced biomarker discovery and the elucidation of mechanisms underlying obesity and its co-morbidities, with a specific focus on metabolic syndrome and psychotic disorders. The importance of identifying metabolic markers of disease-associated intermediate phenotypes – traits modulated but not encoded by the DNA sequence – is emphasized. Such markers would be applicable as diagnostic tools in a personalized healthcare setting and might also open up novel therapeutic avenues.
Original languageEnglish
Pages (from-to)614-620
JournalDisease models & mechanisms
Volume5
Issue number5
DOIs
Publication statusPublished - 2012
MoE publication typeA2 Review article in a scientific journal
EventThe obese species : Clinical and preclinical understanding of eating and energy balance disorders - Erice, Sicily, Italy
Duration: 21 Oct 201126 Oct 2011
http://theobesespecies.unipr.it/program (Workshop Program)

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