Occurrence of beta-hexachlorocyclohexane in breast cancer patients

Helena Mussalo-Rauhamaa, Erkki Häsänen, Heikki Pyysalo, R. Kauppila, P. Pantzar

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

The residues of polycyclic aromatic hydrocarbon (PAH) and neutral organochlorine compounds in breast fat of 44 breast cancer patients and 33 women free of cancer were determined. No statistically significant differences appeared between the two comparison groups with regard to occurrence of PAH compounds. of the neutral organochlorine compounds, residues of beta‐hexachlorocyclohexane (HCH) were found more frequently in breast cancer patients. After adjusting for age and parity by stepwise logistic regression, beta‐HCH remained a significant risk factor of breast cancer. Using a cutoff point for the residue level of beta‐HCH in breast adipose tissue of more than 0.1 mg/kg fat, the odds ratio was 10.51 (95% CI, 2.00–55.26).

Original languageEnglish
Pages (from-to)2124-2128
JournalCancer
Volume66
Issue number10
DOIs
Publication statusPublished - 1990
MoE publication typeA1 Journal article-refereed

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Chlorinated Hydrocarbons
Polycyclic Aromatic Hydrocarbons
Breast Neoplasms
Breast
Fats
Parity
Adipose Tissue
Logistic Models
Odds Ratio
beta-hexachlorocyclohexane
Neoplasms

Cite this

Mussalo-Rauhamaa, H., Häsänen, E., Pyysalo, H., Kauppila, R., & Pantzar, P. (1990). Occurrence of beta-hexachlorocyclohexane in breast cancer patients. Cancer, 66(10), 2124-2128. https://doi.org/10.1002/1097-0142(19901115)66:10<2124::AID-CNCR2820661014>3.0.CO;2-A
Mussalo-Rauhamaa, Helena ; Häsänen, Erkki ; Pyysalo, Heikki ; Kauppila, R. ; Pantzar, P. / Occurrence of beta-hexachlorocyclohexane in breast cancer patients. In: Cancer. 1990 ; Vol. 66, No. 10. pp. 2124-2128.
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abstract = "The residues of polycyclic aromatic hydrocarbon (PAH) and neutral organochlorine compounds in breast fat of 44 breast cancer patients and 33 women free of cancer were determined. No statistically significant differences appeared between the two comparison groups with regard to occurrence of PAH compounds. of the neutral organochlorine compounds, residues of beta‐hexachlorocyclohexane (HCH) were found more frequently in breast cancer patients. After adjusting for age and parity by stepwise logistic regression, beta‐HCH remained a significant risk factor of breast cancer. Using a cutoff point for the residue level of beta‐HCH in breast adipose tissue of more than 0.1 mg/kg fat, the odds ratio was 10.51 (95{\%} CI, 2.00–55.26).",
author = "Helena Mussalo-Rauhamaa and Erkki H{\"a}s{\"a}nen and Heikki Pyysalo and R. Kauppila and P. Pantzar",
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Mussalo-Rauhamaa, H, Häsänen, E, Pyysalo, H, Kauppila, R & Pantzar, P 1990, 'Occurrence of beta-hexachlorocyclohexane in breast cancer patients', Cancer, vol. 66, no. 10, pp. 2124-2128. https://doi.org/10.1002/1097-0142(19901115)66:10<2124::AID-CNCR2820661014>3.0.CO;2-A

Occurrence of beta-hexachlorocyclohexane in breast cancer patients. / Mussalo-Rauhamaa, Helena; Häsänen, Erkki; Pyysalo, Heikki; Kauppila, R.; Pantzar, P.

In: Cancer, Vol. 66, No. 10, 1990, p. 2124-2128.

Research output: Contribution to journalArticleScientificpeer-review

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T1 - Occurrence of beta-hexachlorocyclohexane in breast cancer patients

AU - Mussalo-Rauhamaa, Helena

AU - Häsänen, Erkki

AU - Pyysalo, Heikki

AU - Kauppila, R.

AU - Pantzar, P.

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AB - The residues of polycyclic aromatic hydrocarbon (PAH) and neutral organochlorine compounds in breast fat of 44 breast cancer patients and 33 women free of cancer were determined. No statistically significant differences appeared between the two comparison groups with regard to occurrence of PAH compounds. of the neutral organochlorine compounds, residues of beta‐hexachlorocyclohexane (HCH) were found more frequently in breast cancer patients. After adjusting for age and parity by stepwise logistic regression, beta‐HCH remained a significant risk factor of breast cancer. Using a cutoff point for the residue level of beta‐HCH in breast adipose tissue of more than 0.1 mg/kg fat, the odds ratio was 10.51 (95% CI, 2.00–55.26).

U2 - 10.1002/1097-0142(19901115)66:10<2124::AID-CNCR2820661014>3.0.CO;2-A

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M3 - Article

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