Optical and terahertz measurement techniques for flat-faced pharmaceutical tablets

A case study of gloss, surface roughness and bulk properties of starch acetate tablets

Mikko Juuti, Heikki Tuononen, Tuukka Prykäri, Ville Kontturi, Marko Kuosmanen, Erkki Alarousu, Jarkko Ketolainen, Risto Myllylä, Kai-Erik Peiponen (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

30 Citations (Scopus)

Abstract

Surface and bulk properties of flat-faced starch acetate tablets were studied. For surface quality inspection optical coherence tomography and recently developed diffractive glossmeter were utilized. Both these optical devices together provide local information on surface roughness and gloss of a tablet over a measured area. The concepts of mean topography and mean gloss profile for surface quality of a tablet are introduced. It was observed that the surface quality of the tablet varies, and compression at high pressure may not guarantee a good surface quality of the tablet. Using novel statistical parameters for gloss and relevant surface roughness parameter, it is possible to get more comprehensive quantitative data on the surface condition of a tablet. THz spectrometer was utilized for detection of THz pulse delay in transmission measurement mode from the tablets. The delay time and thickness ratio of the tablet are consistent with the porosity of the tablet as a function of compression pressure. We suggest that the multimeasurement scheme using three different devices helps tablet makers to better assess bulk and surface quality of their products.
Original languageEnglish
Article number015301
Number of pages9
JournalMeasurement Science and Technology
Volume20
Issue number1
DOIs
Publication statusPublished - 2009
MoE publication typeA1 Journal article-refereed

Fingerprint

tablets
Surface Quality
Starch
starches
Measurement Techniques
Pharmaceuticals
Surface Roughness
optical measurement
Drug products
Surface properties
acetates
surface roughness
Surface roughness
Compression
Optical Coherence Tomography
Optical Devices
Optical tomography
Delay Time
Topography
Optical devices

Cite this

Juuti, Mikko ; Tuononen, Heikki ; Prykäri, Tuukka ; Kontturi, Ville ; Kuosmanen, Marko ; Alarousu, Erkki ; Ketolainen, Jarkko ; Myllylä, Risto ; Peiponen, Kai-Erik. / Optical and terahertz measurement techniques for flat-faced pharmaceutical tablets : A case study of gloss, surface roughness and bulk properties of starch acetate tablets. In: Measurement Science and Technology. 2009 ; Vol. 20, No. 1.
@article{4aa72083d5ac4ec6a55f8843362b0e77,
title = "Optical and terahertz measurement techniques for flat-faced pharmaceutical tablets: A case study of gloss, surface roughness and bulk properties of starch acetate tablets",
abstract = "Surface and bulk properties of flat-faced starch acetate tablets were studied. For surface quality inspection optical coherence tomography and recently developed diffractive glossmeter were utilized. Both these optical devices together provide local information on surface roughness and gloss of a tablet over a measured area. The concepts of mean topography and mean gloss profile for surface quality of a tablet are introduced. It was observed that the surface quality of the tablet varies, and compression at high pressure may not guarantee a good surface quality of the tablet. Using novel statistical parameters for gloss and relevant surface roughness parameter, it is possible to get more comprehensive quantitative data on the surface condition of a tablet. THz spectrometer was utilized for detection of THz pulse delay in transmission measurement mode from the tablets. The delay time and thickness ratio of the tablet are consistent with the porosity of the tablet as a function of compression pressure. We suggest that the multimeasurement scheme using three different devices helps tablet makers to better assess bulk and surface quality of their products.",
author = "Mikko Juuti and Heikki Tuononen and Tuukka Pryk{\"a}ri and Ville Kontturi and Marko Kuosmanen and Erkki Alarousu and Jarkko Ketolainen and Risto Myllyl{\"a} and Kai-Erik Peiponen",
year = "2009",
doi = "10.1088/0957-0233/20/1/015301",
language = "English",
volume = "20",
journal = "Measurement Science and Technology",
issn = "0957-0233",
publisher = "Institute of Physics IOP",
number = "1",

}

Optical and terahertz measurement techniques for flat-faced pharmaceutical tablets : A case study of gloss, surface roughness and bulk properties of starch acetate tablets. / Juuti, Mikko; Tuononen, Heikki; Prykäri, Tuukka; Kontturi, Ville; Kuosmanen, Marko; Alarousu, Erkki; Ketolainen, Jarkko; Myllylä, Risto; Peiponen, Kai-Erik (Corresponding Author).

In: Measurement Science and Technology, Vol. 20, No. 1, 015301, 2009.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Optical and terahertz measurement techniques for flat-faced pharmaceutical tablets

T2 - A case study of gloss, surface roughness and bulk properties of starch acetate tablets

AU - Juuti, Mikko

AU - Tuononen, Heikki

AU - Prykäri, Tuukka

AU - Kontturi, Ville

AU - Kuosmanen, Marko

AU - Alarousu, Erkki

AU - Ketolainen, Jarkko

AU - Myllylä, Risto

AU - Peiponen, Kai-Erik

PY - 2009

Y1 - 2009

N2 - Surface and bulk properties of flat-faced starch acetate tablets were studied. For surface quality inspection optical coherence tomography and recently developed diffractive glossmeter were utilized. Both these optical devices together provide local information on surface roughness and gloss of a tablet over a measured area. The concepts of mean topography and mean gloss profile for surface quality of a tablet are introduced. It was observed that the surface quality of the tablet varies, and compression at high pressure may not guarantee a good surface quality of the tablet. Using novel statistical parameters for gloss and relevant surface roughness parameter, it is possible to get more comprehensive quantitative data on the surface condition of a tablet. THz spectrometer was utilized for detection of THz pulse delay in transmission measurement mode from the tablets. The delay time and thickness ratio of the tablet are consistent with the porosity of the tablet as a function of compression pressure. We suggest that the multimeasurement scheme using three different devices helps tablet makers to better assess bulk and surface quality of their products.

AB - Surface and bulk properties of flat-faced starch acetate tablets were studied. For surface quality inspection optical coherence tomography and recently developed diffractive glossmeter were utilized. Both these optical devices together provide local information on surface roughness and gloss of a tablet over a measured area. The concepts of mean topography and mean gloss profile for surface quality of a tablet are introduced. It was observed that the surface quality of the tablet varies, and compression at high pressure may not guarantee a good surface quality of the tablet. Using novel statistical parameters for gloss and relevant surface roughness parameter, it is possible to get more comprehensive quantitative data on the surface condition of a tablet. THz spectrometer was utilized for detection of THz pulse delay in transmission measurement mode from the tablets. The delay time and thickness ratio of the tablet are consistent with the porosity of the tablet as a function of compression pressure. We suggest that the multimeasurement scheme using three different devices helps tablet makers to better assess bulk and surface quality of their products.

U2 - 10.1088/0957-0233/20/1/015301

DO - 10.1088/0957-0233/20/1/015301

M3 - Article

VL - 20

JO - Measurement Science and Technology

JF - Measurement Science and Technology

SN - 0957-0233

IS - 1

M1 - 015301

ER -