Abstract
Surface and bulk properties of flat-faced starch acetate tablets were
studied. For surface quality inspection optical coherence tomography and
recently developed diffractive glossmeter were utilized. Both these
optical devices together provide local information on surface roughness
and gloss of a tablet over a measured area. The concepts of mean
topography and mean gloss profile for surface quality of a tablet are
introduced. It was observed that the surface quality of the tablet
varies, and compression at high pressure may not guarantee a good
surface quality of the tablet. Using novel statistical parameters for
gloss and relevant surface roughness parameter, it is possible to get
more comprehensive quantitative data on the surface condition of a
tablet. THz spectrometer was utilized for detection of THz pulse delay
in transmission measurement mode from the tablets. The delay time and
thickness ratio of the tablet are consistent with the porosity of the
tablet as a function of compression pressure. We suggest that the
multimeasurement scheme using three different devices helps tablet
makers to better assess bulk and surface quality of their products.
Original language | English |
---|---|
Article number | 015301 |
Number of pages | 9 |
Journal | Measurement Science and Technology |
Volume | 20 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2009 |
MoE publication type | A1 Journal article-refereed |