Optical sensing of a pulsating liquid in a brain-mimicking phantom

Teemu Myllylä, Alexey Popov, Vesa Korhonen, Alexander Bykov, Matti Kinnunen

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

12 Citations (Scopus)

Abstract

In study of the brain, oxygenation changes in the cerebral cortex are increasingly monitored using optical methods based on near-infrared spectroscopy (NIRS). When monitoring blood oxygenation in the cerebral cortex, at depth of approximately 15 mm - 20 mm from the skin surface, separation distance between source and detector becomes significant. Many studies show that by increasing the source-detector distance, illuminating light penetrates deeper into tissue. In this work, we use optical phantoms to determine experimentally the minimum source-detector distance between that allows sensing of the cerebral cortex, particularly the grey matter of the brain. A multilayered forehead phantom was fabricated and a silicon tube was added inside the phantom at depths of 15 mm and 19 mm, measured from the surface of the skin mimicking layer. This depth corresponds to the grey matter layer of the brain. The phantom's optical properties were specifically designed to mimic the optical properties of tissue layers of the forehead and to facilitate near-infrared sensing. Optical sensing of liquid movement within the tube was measured by varying the distance between the near-infrared light source and the detector. Based on our measurements, we can conclude that it is possible to sense pulsations from a grey matter mimicking layer of the brain using near-infrared spectroscopy at a source-detector distance of 3 - 4 cm.

Original languageEnglish
Title of host publicationDiffuse Optical Imaging IV
EditorsPaola Taroni, Hamid Dehghani
PublisherInternational Society for Optics and Photonics SPIE
ISBN (Print)978-0-8194-9648-5
DOIs
Publication statusPublished - 12 Aug 2013
MoE publication typeNot Eligible
EventDiffuse Optical Imaging IV - Munich, Germany
Duration: 12 May 201314 May 2013

Publication series

SeriesProgress in Biomedical Optics and Imaging
Number49
Volume14
ISSN1605-7422
SeriesProceedings of SPIE
Volume8799
ISSN0277-786X

Conference

ConferenceDiffuse Optical Imaging IV
CountryGermany
CityMunich
Period12/05/1314/05/13

Keywords

  • Brain
  • Light propagation
  • NIRS
  • Phantom
  • PPG
  • Sensing

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  • Cite this

    Myllylä, T., Popov, A., Korhonen, V., Bykov, A., & Kinnunen, M. (2013). Optical sensing of a pulsating liquid in a brain-mimicking phantom. In P. Taroni, & H. Dehghani (Eds.), Diffuse Optical Imaging IV [87990X] International Society for Optics and Photonics SPIE. Progress in Biomedical Optics and Imaging, No. 49, Vol.. 14, Proceedings of SPIE, Vol.. 8799 https://doi.org/10.1117/12.2033324