Optical sensing of titanium dioxide nanoparticles within horny layer of human skin and their protecting effect against solar UV radiation

Alexey P. Popov, Mikhail Yu. Kirillin, Alexander V. Priezzhev, Jürgen Lademann, Jukka Hast, Risto Myllylä

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

17 Citations (Scopus)

Abstract

In the present paper the problem of protection of human skin against harmful UV solar rays using nano-sized spherical particles of titanium dioxide and sensing their concentration if embedded into skin is considered. Experimental tape-stripping method was used to reveal the in-depth distribution of the particles within the horny layer up to 20 μm. Computer simulations of optical coherence tomography (OCT) investigations of skin and, in particular, horny layer in vitro with and without titanium dioxide particles added were also performed in order to understand, if this modem noninvasive technique is applicable for skin study and revealing the distribution of nanoparticles within the horny layer. The effect of particles size (25-200 nm) and concentration on simulated OCT signals was analyzed. The increase of scattering in the sample (with increase of particles concentration or size) leads to increase of the OCT signal slope and decrease of rear border peak. We also performed simulations implementing the Monte Carlo technique to evaluate the protecting effect of titanium dioxide nanoparticles of different size. The most effective sizes were revealed. Computations were performed for the wavelength of 290.5 nm as the most harmful one. Dependencies of light intensities absorbed, backscattered, and transmitted through the whole horny layer (20 μm thick) on concentration of titanium dioxide particles (0-5%) were obtained and analyzed.

Original languageEnglish
Title of host publicationOptical Diagnostics and Sensing V
EditorsAlexander V. Priezzhev, Gerard L. Coté
PublisherInternational Society for Optics and Photonics SPIE
Pages113-122
ISBN (Print)978-0-8194-5676-2
DOIs
Publication statusPublished - 1 Jan 2005
MoE publication typeA4 Article in a conference publication
EventSPIE BIOS: Optical Diagnostics and Sensing V - San Jose, United States
Duration: 25 Jan 200526 Jan 2005

Publication series

SeriesProceedings of SPIE
Volume5702
ISSN0277-786X
SeriesProgress in Biomedical Optics and Imaging
Number17
Volume6
ISSN1605-7422

Conference

ConferenceSPIE BIOS
CountryUnited States
CitySan Jose
Period25/01/0526/01/05

Keywords

  • Horny layer
  • Human skin
  • Monte Carlo simulation
  • OCT
  • Titanium dioxide particles
  • UV radiation

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