Abstract
The cost function of the model takes into account two optimality criteria for ventricular function: energy economy and efficient response to an increase in V/sub ed/. The observed stroke volumes of isolated canine hearts could be predicted quite accurately by the model. It is concluded that the left-ventricular response to a change in arterial load and V/sub ed/ can be explained by an optimization model when contractility and heart rate are kept constant.
The results also strongly suggest that energy economy and efficiency are essential features of left-ventricular function.
| Original language | English |
|---|---|
| Pages (from-to) | 172-182 |
| Journal | IEEE Transactions on Biomedical Engineering |
| Volume | 36 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1989 |
| MoE publication type | A1 Journal article-refereed |
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Optimal stroke volume in left-ventricular ejection. / Hämäläinen, Jari.
In: IEEE Transactions on Biomedical Engineering, Vol. 36, No. 2, 1989, p. 172-182.Research output: Contribution to journal › Article › Scientific › peer-review
TY - JOUR
T1 - Optimal stroke volume in left-ventricular ejection
AU - Hämäläinen, Jari
PY - 1989
Y1 - 1989
N2 - Optimal value of stroke volume ejected against a given arterial load is studied, i.e. left-ventricular function is described by an optimization model. In the model, end-diastolic volume (V/sub ed/), the linear end-systolic pressure-volume relation, heart rate, and ejection time are given, and arterial load is described by the three-element windkessel model. The cost function of the model takes into account two optimality criteria for ventricular function: energy economy and efficient response to an increase in V/sub ed/. The observed stroke volumes of isolated canine hearts could be predicted quite accurately by the model. It is concluded that the left-ventricular response to a change in arterial load and V/sub ed/ can be explained by an optimization model when contractility and heart rate are kept constant. The results also strongly suggest that energy economy and efficiency are essential features of left-ventricular function.
AB - Optimal value of stroke volume ejected against a given arterial load is studied, i.e. left-ventricular function is described by an optimization model. In the model, end-diastolic volume (V/sub ed/), the linear end-systolic pressure-volume relation, heart rate, and ejection time are given, and arterial load is described by the three-element windkessel model. The cost function of the model takes into account two optimality criteria for ventricular function: energy economy and efficient response to an increase in V/sub ed/. The observed stroke volumes of isolated canine hearts could be predicted quite accurately by the model. It is concluded that the left-ventricular response to a change in arterial load and V/sub ed/ can be explained by an optimization model when contractility and heart rate are kept constant. The results also strongly suggest that energy economy and efficiency are essential features of left-ventricular function.
U2 - 10.1109/10.16464
DO - 10.1109/10.16464
M3 - Article
VL - 36
SP - 172
EP - 182
JO - IEEE Transactions on Biomedical Engineering
JF - IEEE Transactions on Biomedical Engineering
SN - 0018-9294
IS - 2
ER -