Optimal stroke volume in left-ventricular ejection

Jari Hämäläinen

doi:10.1109/10.16464

Optimal stroke volume in left-ventricular ejection

Jari Hämäläinen

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

Optimal value of stroke volume ejected against a given arterial load is studied, i.e. left-ventricular function is described by an optimization model. In the model, end-diastolic volume (V_ed), the linear end-systolic pressure-volume relation, heart rate, and ejection time are given, and arterial load is described by the three-element windkessel model. The cost function of the model takes into account two optimality criteria for ventricular function: energy economy and efficient response to an increase in V_ed. The observed stroke volumes of isolated canine hearts could be predicted quite accurately by the model. It is concluded that the left-ventricular response to a change in arterial load and V_ed can be explained by an optimization model when contractility and heart rate are kept constant. The results also strongly suggest that energy economy and efficiency are essential features of left-ventricular function.

Original language	English
Pages (from-to)	172-182
Journal	IEEE Transactions on Biomedical Engineering
Volume	36
Issue number	2
DOIs	https://doi.org/10.1109/10.16464
Publication status	Published - 1989
MoE publication type	A1 Journal article-refereed

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title = "Optimal stroke volume in left-ventricular ejection",

abstract = "Optimal value of stroke volume ejected against a given arterial load is studied, i.e. left-ventricular function is described by an optimization model. In the model, end-diastolic volume (Ved), the linear end-systolic pressure-volume relation, heart rate, and ejection time are given, and arterial load is described by the three-element windkessel model. The cost function of the model takes into account two optimality criteria for ventricular function: energy economy and efficient response to an increase in Ved. The observed stroke volumes of isolated canine hearts could be predicted quite accurately by the model. It is concluded that the left-ventricular response to a change in arterial load and Ved can be explained by an optimization model when contractility and heart rate are kept constant. The results also strongly suggest that energy economy and efficiency are essential features of left-ventricular function.",

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AB - Optimal value of stroke volume ejected against a given arterial load is studied, i.e. left-ventricular function is described by an optimization model. In the model, end-diastolic volume (Ved), the linear end-systolic pressure-volume relation, heart rate, and ejection time are given, and arterial load is described by the three-element windkessel model. The cost function of the model takes into account two optimality criteria for ventricular function: energy economy and efficient response to an increase in Ved. The observed stroke volumes of isolated canine hearts could be predicted quite accurately by the model. It is concluded that the left-ventricular response to a change in arterial load and Ved can be explained by an optimization model when contractility and heart rate are kept constant. The results also strongly suggest that energy economy and efficiency are essential features of left-ventricular function.

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Optimal stroke volume in left-ventricular ejection

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