Abstract
Optimal value of stroke volume ejected against a given arterial load is studied, i.e. left-ventricular function is described by an optimization model. In the model, end-diastolic volume (V/sub ed/), the linear end-systolic pressure-volume relation, heart rate, and ejection time are given, and arterial load is described by the three-element windkessel model.
The cost function of the model takes into account two optimality criteria for ventricular function: energy economy and efficient response to an increase in V/sub ed/. The observed stroke volumes of isolated canine hearts could be predicted quite accurately by the model. It is concluded that the left-ventricular response to a change in arterial load and V/sub ed/ can be explained by an optimization model when contractility and heart rate are kept constant.
The results also strongly suggest that energy economy and efficiency are essential features of left-ventricular function.
The cost function of the model takes into account two optimality criteria for ventricular function: energy economy and efficient response to an increase in V/sub ed/. The observed stroke volumes of isolated canine hearts could be predicted quite accurately by the model. It is concluded that the left-ventricular response to a change in arterial load and V/sub ed/ can be explained by an optimization model when contractility and heart rate are kept constant.
The results also strongly suggest that energy economy and efficiency are essential features of left-ventricular function.
| Original language | English |
|---|---|
| Pages (from-to) | 172-182 |
| Journal | IEEE Transactions on Biomedical Engineering |
| Volume | 36 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1989 |
| MoE publication type | A1 Journal article-refereed |