Pharmacokinetic aspects of retinal drug delivery

Eva M. del Amo, Anna Kaisa Rimpelä, Emma Heikkinen, Otto K. Kari, Eva Ramsay, Tatu Lajunen, Mechthild Schmitt, Laura Pelkonen, Madhushree Bhattacharya, Dominique Richardson, Astrid Subrizi, Tiina Turunen, Mika Reinisalo, Jaakko Itkonen, Elisa Toropainen, Marco Casteleijn, Heidi Kidron, Maxim Antopolsky, Kati Sisko Vellonen, Marika RuponenArto Urtti

Research output: Contribution to journalArticleScientificpeer-review

92 Citations (Scopus)

Abstract

Drug delivery to the posterior eye segment is an important challenge in ophthalmology, because many diseases affect the retina and choroid leading to impaired vision or blindness. Currently, intravitreal injections are the method of choice to administer drugs to the retina, but this approach is applicable only in selected cases (e.g. anti-VEGF antibodies and soluble receptors). There are two basic approaches that can be adopted to improve retinal drug delivery: prolonged and/or retina targeted delivery of intravitreal drugs and use of other routes of drug administration, such as periocular, suprachoroidal, sub-retinal, systemic, or topical. Properties of the administration route, drug and delivery system determine the efficacy and safety of these approaches. Pharmacokinetic and pharmacodynamic factors determine the required dosing rates and doses that are needed for drug action. In addition, tolerability factors limit the use of many materials in ocular drug delivery. This review article provides a critical discussion of retinal drug delivery, particularly from the pharmacokinetic point of view. This article does not include an extensive review of drug delivery technologies, because they have already been reviewed several times recently. Instead, we aim to provide a systematic and quantitative view on the pharmacokinetic factors in drug delivery to the posterior eye segment. This review is based on the literature and unpublished data from the authors' laboratory.
Original languageEnglish
Pages (from-to)134-185
Number of pages52
JournalProgress in Retinal and Eye Research
Volume57
DOIs
Publication statusPublished - Mar 2017
MoE publication typeA1 Journal article-refereed

Fingerprint

Pharmacokinetics
Pharmaceutical Preparations
Posterior Eye Segment
Retina
Drug Administration Routes
Intravitreal Injections
Choroid
Ophthalmology
Blindness
Drug Delivery Systems
Vascular Endothelial Growth Factor A
Anti-Idiotypic Antibodies
Technology
Safety

Keywords

  • Choroid
  • Clearance
  • Distribution
  • Intravitreal
  • Pharmacokinetic modeling
  • Retina
  • Sub-conjunctival
  • Suprachoroidal
  • Topical
  • Transport
  • Vitreous

Cite this

del Amo, E. M., Rimpelä, A. K., Heikkinen, E., Kari, O. K., Ramsay, E., Lajunen, T., ... Urtti, A. (2017). Pharmacokinetic aspects of retinal drug delivery. Progress in Retinal and Eye Research, 57, 134-185. https://doi.org/10.1016/j.preteyeres.2016.12.001
del Amo, Eva M. ; Rimpelä, Anna Kaisa ; Heikkinen, Emma ; Kari, Otto K. ; Ramsay, Eva ; Lajunen, Tatu ; Schmitt, Mechthild ; Pelkonen, Laura ; Bhattacharya, Madhushree ; Richardson, Dominique ; Subrizi, Astrid ; Turunen, Tiina ; Reinisalo, Mika ; Itkonen, Jaakko ; Toropainen, Elisa ; Casteleijn, Marco ; Kidron, Heidi ; Antopolsky, Maxim ; Vellonen, Kati Sisko ; Ruponen, Marika ; Urtti, Arto. / Pharmacokinetic aspects of retinal drug delivery. In: Progress in Retinal and Eye Research. 2017 ; Vol. 57. pp. 134-185.
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del Amo, EM, Rimpelä, AK, Heikkinen, E, Kari, OK, Ramsay, E, Lajunen, T, Schmitt, M, Pelkonen, L, Bhattacharya, M, Richardson, D, Subrizi, A, Turunen, T, Reinisalo, M, Itkonen, J, Toropainen, E, Casteleijn, M, Kidron, H, Antopolsky, M, Vellonen, KS, Ruponen, M & Urtti, A 2017, 'Pharmacokinetic aspects of retinal drug delivery', Progress in Retinal and Eye Research, vol. 57, pp. 134-185. https://doi.org/10.1016/j.preteyeres.2016.12.001

Pharmacokinetic aspects of retinal drug delivery. / del Amo, Eva M.; Rimpelä, Anna Kaisa; Heikkinen, Emma; Kari, Otto K.; Ramsay, Eva; Lajunen, Tatu; Schmitt, Mechthild; Pelkonen, Laura; Bhattacharya, Madhushree; Richardson, Dominique; Subrizi, Astrid; Turunen, Tiina; Reinisalo, Mika; Itkonen, Jaakko; Toropainen, Elisa; Casteleijn, Marco; Kidron, Heidi; Antopolsky, Maxim; Vellonen, Kati Sisko; Ruponen, Marika; Urtti, Arto (Corresponding Author).

In: Progress in Retinal and Eye Research, Vol. 57, 03.2017, p. 134-185.

Research output: Contribution to journalArticleScientificpeer-review

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AU - del Amo, Eva M.

AU - Rimpelä, Anna Kaisa

AU - Heikkinen, Emma

AU - Kari, Otto K.

AU - Ramsay, Eva

AU - Lajunen, Tatu

AU - Schmitt, Mechthild

AU - Pelkonen, Laura

AU - Bhattacharya, Madhushree

AU - Richardson, Dominique

AU - Subrizi, Astrid

AU - Turunen, Tiina

AU - Reinisalo, Mika

AU - Itkonen, Jaakko

AU - Toropainen, Elisa

AU - Casteleijn, Marco

AU - Kidron, Heidi

AU - Antopolsky, Maxim

AU - Vellonen, Kati Sisko

AU - Ruponen, Marika

AU - Urtti, Arto

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KW - Clearance

KW - Distribution

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KW - Pharmacokinetic modeling

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KW - Sub-conjunctival

KW - Suprachoroidal

KW - Topical

KW - Transport

KW - Vitreous

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del Amo EM, Rimpelä AK, Heikkinen E, Kari OK, Ramsay E, Lajunen T et al. Pharmacokinetic aspects of retinal drug delivery. Progress in Retinal and Eye Research. 2017 Mar;57:134-185. https://doi.org/10.1016/j.preteyeres.2016.12.001