Pharmacokinetics and Clinical Effects of Scopolamine in Caesarean Section Patients

K. K. Pihlajamäki, J. H. Kanto, Kirsi ‐Marja Oksman‐Caldentey

Research output: Contribution to journalArticleScientificpeer-review

18 Citations (Scopus)


Abstract: A new method (ELISA) was used to evaluate the pharmacokinetics of scopolamine following intravenous (0.005 mg/kg), intramuscular (0.01 mg/kg), and oropharyngeal (0.035 mg/kg) administration of the drug to pregnant patients anaesthetized for caesarean section. After intravenous (N = 4) the drug fast disappeared from the circulation with a half‐life of about 5 min., and the serum levels generally were measurable up to 3 hours, mean elimination half‐life was 1.85 hours. A fast absorption was found after intramuscular injection, tmax = 10 min. (N = 4), and the drug had a clinically significant oropharyngeal absorption as well, tmax was around 1 hour (N = 6). The intramuscular and oropharyngeal, but not the intravenous, administrations produced a marked postoperative sedative and amnesic effects. All three administration ways caused a significant antisecretory action. 1986 Nordic Pharmacological Society

Original languageEnglish
Pages (from-to)259-262
Number of pages4
JournalActa Pharmacologica et Toxicologica
Issue number4
Publication statusPublished - Oct 1986
MoE publication typeA1 Journal article-refereed


  • clinical effects
  • humans
  • pharmacokinetics
  • Scopolamine
  • serum levels


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