Pharmacokinetics and Clinical Effects of Scopolamine in Caesarean Section Patients

K. K. Pihlajamäki; J. H. Kanto; Kirsi ‐Marja Oksman‐Caldentey

doi:10.1111/j.1600-0773.1986.tb00166.x

Pharmacokinetics and Clinical Effects of Scopolamine in Caesarean Section Patients

K. K. Pihlajamäki^*, J. H. Kanto, Kirsi ‐Marja Oksman‐Caldentey

^*Corresponding author for this work

Not published at VTT

Research output: Contribution to journal › Article › Scientific › peer-review

18 Citations (Scopus)

Abstract

Abstract: A new method (ELISA) was used to evaluate the pharmacokinetics of scopolamine following intravenous (0.005 mg/kg), intramuscular (0.01 mg/kg), and oropharyngeal (0.035 mg/kg) administration of the drug to pregnant patients anaesthetized for caesarean section. After intravenous (N = 4) the drug fast disappeared from the circulation with a half‐life of about 5 min., and the serum levels generally were measurable up to 3 hours, mean elimination half‐life was 1.85 hours. A fast absorption was found after intramuscular injection, t_max = 10 min. (N = 4), and the drug had a clinically significant oropharyngeal absorption as well, t_max was around 1 hour (N = 6). The intramuscular and oropharyngeal, but not the intravenous, administrations produced a marked postoperative sedative and amnesic effects. All three administration ways caused a significant antisecretory action. 1986 Nordic Pharmacological Society

Original language	English
Pages (from-to)	259-262
Number of pages	4
Journal	Acta Pharmacologica et Toxicologica
Volume	59
Issue number	4
DOIs	https://doi.org/10.1111/j.1600-0773.1986.tb00166.x
Publication status	Published - Oct 1986
MoE publication type	A1 Journal article-refereed

Keywords

clinical effects
ELISA
humans
pharmacokinetics
Scopolamine
serum levels

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10.1111/j.1600-0773.1986.tb00166.x

Cite this

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title = "Pharmacokinetics and Clinical Effects of Scopolamine in Caesarean Section Patients",

abstract = "Abstract: A new method (ELISA) was used to evaluate the pharmacokinetics of scopolamine following intravenous (0.005 mg/kg), intramuscular (0.01 mg/kg), and oropharyngeal (0.035 mg/kg) administration of the drug to pregnant patients anaesthetized for caesarean section. After intravenous (N = 4) the drug fast disappeared from the circulation with a half‐life of about 5 min., and the serum levels generally were measurable up to 3 hours, mean elimination half‐life was 1.85 hours. A fast absorption was found after intramuscular injection, tmax = 10 min. (N = 4), and the drug had a clinically significant oropharyngeal absorption as well, tmax was around 1 hour (N = 6). The intramuscular and oropharyngeal, but not the intravenous, administrations produced a marked postoperative sedative and amnesic effects. All three administration ways caused a significant antisecretory action. 1986 Nordic Pharmacological Society",

keywords = "clinical effects, ELISA, humans, pharmacokinetics, Scopolamine, serum levels",

author = "Pihlajam{\"a}ki, {K. K.} and Kanto, {J. H.} and Oksman‐Caldentey, {Kirsi ‐Marja}",

year = "1986",

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AU - Pihlajamäki, K. K.

AU - Kanto, J. H.

AU - Oksman‐Caldentey, Kirsi ‐Marja

PY - 1986/10

Y1 - 1986/10

N2 - Abstract: A new method (ELISA) was used to evaluate the pharmacokinetics of scopolamine following intravenous (0.005 mg/kg), intramuscular (0.01 mg/kg), and oropharyngeal (0.035 mg/kg) administration of the drug to pregnant patients anaesthetized for caesarean section. After intravenous (N = 4) the drug fast disappeared from the circulation with a half‐life of about 5 min., and the serum levels generally were measurable up to 3 hours, mean elimination half‐life was 1.85 hours. A fast absorption was found after intramuscular injection, tmax = 10 min. (N = 4), and the drug had a clinically significant oropharyngeal absorption as well, tmax was around 1 hour (N = 6). The intramuscular and oropharyngeal, but not the intravenous, administrations produced a marked postoperative sedative and amnesic effects. All three administration ways caused a significant antisecretory action. 1986 Nordic Pharmacological Society

AB - Abstract: A new method (ELISA) was used to evaluate the pharmacokinetics of scopolamine following intravenous (0.005 mg/kg), intramuscular (0.01 mg/kg), and oropharyngeal (0.035 mg/kg) administration of the drug to pregnant patients anaesthetized for caesarean section. After intravenous (N = 4) the drug fast disappeared from the circulation with a half‐life of about 5 min., and the serum levels generally were measurable up to 3 hours, mean elimination half‐life was 1.85 hours. A fast absorption was found after intramuscular injection, tmax = 10 min. (N = 4), and the drug had a clinically significant oropharyngeal absorption as well, tmax was around 1 hour (N = 6). The intramuscular and oropharyngeal, but not the intravenous, administrations produced a marked postoperative sedative and amnesic effects. All three administration ways caused a significant antisecretory action. 1986 Nordic Pharmacological Society

KW - clinical effects

KW - ELISA

KW - humans

KW - pharmacokinetics

KW - Scopolamine

KW - serum levels

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JO - Acta Pharmacologica et Toxicologica

JF - Acta Pharmacologica et Toxicologica

IS - 4

ER -

Pharmacokinetics and Clinical Effects of Scopolamine in Caesarean Section Patients

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Keywords

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