Phenolic metabolites as compliance biomarker for polyphenol intake in a randomized controlled human intervention

C Vetrani; A A Rivellese; G Annuzzi; Ismo Mattila; E Meudec; Tuulia Hyötyläinen; Matej Oresic; Anna-Marja Aura

doi:10.1016/j.foodres.2014.01.018

Phenolic metabolites as compliance biomarker for polyphenol intake in a randomized controlled human intervention

C Vetrani, A A Rivellese, G Annuzzi, Ismo Mattila, E Meudec, Tuulia Hyötyläinen, Matej Oresic, Anna-Marja Aura (Corresponding Author)

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Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

Clinical trials are needed to confirm the association between polyphenol consumption and lower incidence of chronic diseases observed in epidemiological studies. However, a reliable evaluation of polyphenol intake is complicated. An 8-week randomized controlled trial (78 subjects) was performed using two isoenergetic diets differing only for polyphenol contents. Then, urinary phenolic metabolite profiles were analysed using gas-chromatography with mass detection. Phenolic metabolites detected in 24-h-urine were hydroxylated phenolic acids with C1-C3 side chain in the group consuming polyphenol-rich diet. The intake of polyphenol-rich foods increases the excretion of phenolic metabolites in urine providing a profile, which may serve as compliance biomarker of polyphenol-rich diet

Original language	English
Pages (from-to)	233-238
Number of pages	5
Journal	Food Research International
Volume	63
Issue number	Part B
DOIs	https://doi.org/10.1016/j.foodres.2014.01.018
Publication status	Published - 2014
MoE publication type	A1 Journal article-refereed

Keywords

Biomarkers
dietary polyphenol
human compliance
phenolic metabolites

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@article{78d7e04e1561410c91736f2c9a12942e,

title = "Phenolic metabolites as compliance biomarker for polyphenol intake in a randomized controlled human intervention",

abstract = "Clinical trials are needed to confirm the association between polyphenol consumption and lower incidence of chronic diseases observed in epidemiological studies. However, a reliable evaluation of polyphenol intake is complicated. An 8-week randomized controlled trial (78 subjects) was performed using two isoenergetic diets differing only for polyphenol contents. Then, urinary phenolic metabolite profiles were analysed using gas-chromatography with mass detection. Phenolic metabolites detected in 24-h-urine were hydroxylated phenolic acids with C1-C3 side chain in the group consuming polyphenol-rich diet. The intake of polyphenol-rich foods increases the excretion of phenolic metabolites in urine providing a profile, which may serve as compliance biomarker of polyphenol-rich diet",

keywords = "Biomarkers, dietary polyphenol, human compliance, phenolic metabolites",

author = "C Vetrani and Rivellese, {A A} and G Annuzzi and Ismo Mattila and E Meudec and Tuulia Hy{\"o}tyl{\"a}inen and Matej Oresic and Anna-Marja Aura",

year = "2014",

doi = "10.1016/j.foodres.2014.01.018",

language = "English",

volume = "63",

pages = "233--238",

journal = "Food Research International",

issn = "0963-9969",

publisher = "Elsevier",

number = "Part B",

}

Phenolic metabolites as compliance biomarker for polyphenol intake in a randomized controlled human intervention. / Vetrani, C; Rivellese, A A; Annuzzi, G; Mattila, Ismo; Meudec, E; Hyötyläinen, Tuulia; Oresic, Matej; Aura, Anna-Marja (Corresponding Author).

In: Food Research International, Vol. 63, No. Part B, 2014, p. 233-238.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Phenolic metabolites as compliance biomarker for polyphenol intake in a randomized controlled human intervention

AU - Vetrani, C

AU - Rivellese, A A

AU - Annuzzi, G

AU - Mattila, Ismo

AU - Meudec, E

AU - Hyötyläinen, Tuulia

AU - Oresic, Matej

AU - Aura, Anna-Marja

PY - 2014

Y1 - 2014

N2 - Clinical trials are needed to confirm the association between polyphenol consumption and lower incidence of chronic diseases observed in epidemiological studies. However, a reliable evaluation of polyphenol intake is complicated. An 8-week randomized controlled trial (78 subjects) was performed using two isoenergetic diets differing only for polyphenol contents. Then, urinary phenolic metabolite profiles were analysed using gas-chromatography with mass detection. Phenolic metabolites detected in 24-h-urine were hydroxylated phenolic acids with C1-C3 side chain in the group consuming polyphenol-rich diet. The intake of polyphenol-rich foods increases the excretion of phenolic metabolites in urine providing a profile, which may serve as compliance biomarker of polyphenol-rich diet

AB - Clinical trials are needed to confirm the association between polyphenol consumption and lower incidence of chronic diseases observed in epidemiological studies. However, a reliable evaluation of polyphenol intake is complicated. An 8-week randomized controlled trial (78 subjects) was performed using two isoenergetic diets differing only for polyphenol contents. Then, urinary phenolic metabolite profiles were analysed using gas-chromatography with mass detection. Phenolic metabolites detected in 24-h-urine were hydroxylated phenolic acids with C1-C3 side chain in the group consuming polyphenol-rich diet. The intake of polyphenol-rich foods increases the excretion of phenolic metabolites in urine providing a profile, which may serve as compliance biomarker of polyphenol-rich diet

KW - Biomarkers

KW - dietary polyphenol

KW - human compliance

KW - phenolic metabolites

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DO - 10.1016/j.foodres.2014.01.018

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VL - 63

SP - 233

EP - 238

JO - Food Research International

JF - Food Research International

SN - 0963-9969

IS - Part B

ER -