Phenolic metabolites as compliance biomarker for polyphenol intake in a randomized controlled human intervention

C Vetrani, A A Rivellese, G Annuzzi, Ismo Mattila, E Meudec, Tuulia Hyötyläinen, Matej Oresic, Anna-Marja Aura (Corresponding Author)

    Research output: Contribution to journalArticleScientificpeer-review

    21 Citations (Scopus)

    Abstract

    Clinical trials are needed to confirm the association between polyphenol consumption and lower incidence of chronic diseases observed in epidemiological studies. However, a reliable evaluation of polyphenol intake is complicated. An 8-week randomized controlled trial (78 subjects) was performed using two isoenergetic diets differing only for polyphenol contents. Then, urinary phenolic metabolite profiles were analysed using gas-chromatography with mass detection. Phenolic metabolites detected in 24-h-urine were hydroxylated phenolic acids with C1-C3 side chain in the group consuming polyphenol-rich diet. The intake of polyphenol-rich foods increases the excretion of phenolic metabolites in urine providing a profile, which may serve as compliance biomarker of polyphenol-rich diet
    Original languageEnglish
    Pages (from-to)233-238
    Number of pages5
    JournalFood Research International
    Volume63
    Issue numberPart B
    DOIs
    Publication statusPublished - 2014
    MoE publication typeA1 Journal article-refereed

    Keywords

    • Biomarkers
    • dietary polyphenol
    • human compliance
    • phenolic metabolites

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