Phenolic metabolites as compliance biomarker for polyphenol intake in a randomized controlled human intervention

C Vetrani, A A Rivellese, G Annuzzi, Ismo Mattila, E Meudec, Tuulia Hyötyläinen, Matej Oresic, Anna-Marja Aura (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

14 Citations (Scopus)

Abstract

Clinical trials are needed to confirm the association between polyphenol consumption and lower incidence of chronic diseases observed in epidemiological studies. However, a reliable evaluation of polyphenol intake is complicated. An 8-week randomized controlled trial (78 subjects) was performed using two isoenergetic diets differing only for polyphenol contents. Then, urinary phenolic metabolite profiles were analysed using gas-chromatography with mass detection. Phenolic metabolites detected in 24-h-urine were hydroxylated phenolic acids with C1-C3 side chain in the group consuming polyphenol-rich diet. The intake of polyphenol-rich foods increases the excretion of phenolic metabolites in urine providing a profile, which may serve as compliance biomarker of polyphenol-rich diet
Original languageEnglish
Pages (from-to)233-238
Number of pages5
JournalFood Research International
Volume63
Issue numberPart B
DOIs
Publication statusPublished - 2014
MoE publication typeA1 Journal article-refereed

Fingerprint

Polyphenols
compliance
Compliance
biomarkers
polyphenols
Biomarkers
metabolites
Diet
urine
Urine
diet
phenolic acids
chronic diseases
Gas Chromatography
epidemiological studies
Epidemiologic Studies
clinical trials
Chronic Disease
Randomized Controlled Trials
excretion

Keywords

  • Biomarkers
  • dietary polyphenol
  • human compliance
  • phenolic metabolites

Cite this

Vetrani, C ; Rivellese, A A ; Annuzzi, G ; Mattila, Ismo ; Meudec, E ; Hyötyläinen, Tuulia ; Oresic, Matej ; Aura, Anna-Marja. / Phenolic metabolites as compliance biomarker for polyphenol intake in a randomized controlled human intervention. In: Food Research International. 2014 ; Vol. 63, No. Part B. pp. 233-238.
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Vetrani, C, Rivellese, AA, Annuzzi, G, Mattila, I, Meudec, E, Hyötyläinen, T, Oresic, M & Aura, A-M 2014, 'Phenolic metabolites as compliance biomarker for polyphenol intake in a randomized controlled human intervention', Food Research International, vol. 63, no. Part B, pp. 233-238. https://doi.org/10.1016/j.foodres.2014.01.018

Phenolic metabolites as compliance biomarker for polyphenol intake in a randomized controlled human intervention. / Vetrani, C; Rivellese, A A; Annuzzi, G; Mattila, Ismo; Meudec, E; Hyötyläinen, Tuulia; Oresic, Matej; Aura, Anna-Marja (Corresponding Author).

In: Food Research International, Vol. 63, No. Part B, 2014, p. 233-238.

Research output: Contribution to journalArticleScientificpeer-review

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T1 - Phenolic metabolites as compliance biomarker for polyphenol intake in a randomized controlled human intervention

AU - Vetrani, C

AU - Rivellese, A A

AU - Annuzzi, G

AU - Mattila, Ismo

AU - Meudec, E

AU - Hyötyläinen, Tuulia

AU - Oresic, Matej

AU - Aura, Anna-Marja

PY - 2014

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AB - Clinical trials are needed to confirm the association between polyphenol consumption and lower incidence of chronic diseases observed in epidemiological studies. However, a reliable evaluation of polyphenol intake is complicated. An 8-week randomized controlled trial (78 subjects) was performed using two isoenergetic diets differing only for polyphenol contents. Then, urinary phenolic metabolite profiles were analysed using gas-chromatography with mass detection. Phenolic metabolites detected in 24-h-urine were hydroxylated phenolic acids with C1-C3 side chain in the group consuming polyphenol-rich diet. The intake of polyphenol-rich foods increases the excretion of phenolic metabolites in urine providing a profile, which may serve as compliance biomarker of polyphenol-rich diet

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