Phenolic metabolites as compliance biomarker for polyphenol intake in a randomized controlled human intervention

C Vetrani, A A Rivellese, G Annuzzi, Ismo Mattila, E Meudec, Tuulia Hyötyläinen, Matej Oresic, Anna-Marja Aura (Corresponding Author)

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Abstract

Clinical trials are needed to confirm the association between polyphenol consumption and lower incidence of chronic diseases observed in epidemiological studies. However, a reliable evaluation of polyphenol intake is complicated. An 8-week randomized controlled trial (78 subjects) was performed using two isoenergetic diets differing only for polyphenol contents. Then, urinary phenolic metabolite profiles were analysed using gas-chromatography with mass detection. Phenolic metabolites detected in 24-h-urine were hydroxylated phenolic acids with C1-C3 side chain in the group consuming polyphenol-rich diet. The intake of polyphenol-rich foods increases the excretion of phenolic metabolites in urine providing a profile, which may serve as compliance biomarker of polyphenol-rich diet
Original languageEnglish
Pages (from-to)233-238
Number of pages5
JournalFood Research International
Volume63
Issue numberPart B
DOIs
Publication statusPublished - 2014
MoE publication typeA1 Journal article-refereed

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Keywords

  • Biomarkers
  • dietary polyphenol
  • human compliance
  • phenolic metabolites

Cite this

Vetrani, C., Rivellese, A. A., Annuzzi, G., Mattila, I., Meudec, E., Hyötyläinen, T., Oresic, M., & Aura, A-M. (2014). Phenolic metabolites as compliance biomarker for polyphenol intake in a randomized controlled human intervention. Food Research International, 63(Part B), 233-238. https://doi.org/10.1016/j.foodres.2014.01.018