Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 233-238 |
| Number of pages | 5 |
| Journal | Food Research International |
| Volume | 63 |
| Issue number | Part B |
| DOIs | |
| Publication status | Published - 2014 |
| MoE publication type | A1 Journal article-refereed |
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Keywords
- Biomarkers
- dietary polyphenol
- human compliance
- phenolic metabolites
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Phenolic metabolites as compliance biomarker for polyphenol intake in a randomized controlled human intervention. / Vetrani, C; Rivellese, A A; Annuzzi, G; Mattila, Ismo; Meudec, E; Hyötyläinen, Tuulia; Oresic, Matej; Aura, Anna-Marja (Corresponding Author).
In: Food Research International, Vol. 63, No. Part B, 2014, p. 233-238.Research output: Contribution to journal › Article › Scientific › peer-review
TY - JOUR
T1 - Phenolic metabolites as compliance biomarker for polyphenol intake in a randomized controlled human intervention
AU - Vetrani, C
AU - Rivellese, A A
AU - Annuzzi, G
AU - Mattila, Ismo
AU - Meudec, E
AU - Hyötyläinen, Tuulia
AU - Oresic, Matej
AU - Aura, Anna-Marja
PY - 2014
Y1 - 2014
N2 - Clinical trials are needed to confirm the association between polyphenol consumption and lower incidence of chronic diseases observed in epidemiological studies. However, a reliable evaluation of polyphenol intake is complicated. An 8-week randomized controlled trial (78 subjects) was performed using two isoenergetic diets differing only for polyphenol contents. Then, urinary phenolic metabolite profiles were analysed using gas-chromatography with mass detection. Phenolic metabolites detected in 24-h-urine were hydroxylated phenolic acids with C1-C3 side chain in the group consuming polyphenol-rich diet. The intake of polyphenol-rich foods increases the excretion of phenolic metabolites in urine providing a profile, which may serve as compliance biomarker of polyphenol-rich diet
AB - Clinical trials are needed to confirm the association between polyphenol consumption and lower incidence of chronic diseases observed in epidemiological studies. However, a reliable evaluation of polyphenol intake is complicated. An 8-week randomized controlled trial (78 subjects) was performed using two isoenergetic diets differing only for polyphenol contents. Then, urinary phenolic metabolite profiles were analysed using gas-chromatography with mass detection. Phenolic metabolites detected in 24-h-urine were hydroxylated phenolic acids with C1-C3 side chain in the group consuming polyphenol-rich diet. The intake of polyphenol-rich foods increases the excretion of phenolic metabolites in urine providing a profile, which may serve as compliance biomarker of polyphenol-rich diet
KW - Biomarkers
KW - dietary polyphenol
KW - human compliance
KW - phenolic metabolites
U2 - 10.1016/j.foodres.2014.01.018
DO - 10.1016/j.foodres.2014.01.018
M3 - Article
VL - 63
SP - 233
EP - 238
JO - Food Research International
JF - Food Research International
SN - 0963-9969
IS - Part B
ER -