Plant cell factories in the post-genomic era: New ways to produce designer secondary metabolites

Kirsi-Marja Oksman-Caldentey (Corresponding Author), Dirk Inze

    Research output: Contribution to journalArticleScientificpeer-review

    360 Citations (Scopus)

    Abstract

    Plants synthesize an extensive array of secondary metabolites, often with highly complex structures. Currently, most pharmaceutically important secondary metabolites are isolated from wild or cultivated plants because their chemical synthesis is not economically feasible. Biotechnological production in plant cell cultures is an attractive alternative, but to date this has had only limited commercial success because of a lack of understanding of how these metabolites are synthesized. Here, we discuss how the spectacular advances in plant genomics and metabolite profiling offer unprecedented possibilities to explore the extraordinary complexity of the plant biochemical capacity. State-of-the art genomics tools can be used to enhance the production of known target metabolites or to synthesize entire novel compounds by so-called combinatorial biochemistry in cultivated plant cells.
    Original languageEnglish
    Pages (from-to)433 - 440
    Number of pages8
    JournalTrends in Plant Science
    Volume9
    Issue number9
    DOIs
    Publication statusPublished - 2004
    MoE publication typeA1 Journal article-refereed

    Keywords

    • metabolomics
    • plant metabolites
    • metabolites
    • secondary metabolism
    • secondary metabolites
    • plants

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