Plasma alkylresorcinols C17:0/C21:0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity

a randomized study

O K Magnusdottir (Corresponding Author), R Landberg, I Gunnarsdottir, L Cloetens, B Åkesson, M Landin-Olsson, F Rosqvist, D Iggman, U Schwab, K-H Herzig, M J Savolainen, L Brader, K Hermansen, Marjukka Kolehmainen, Kaisa Poutanen, M Uusitupa, I Thorsdottir, U Riserus

Research output: Contribution to journalArticleScientificpeer-review

18 Citations (Scopus)

Abstract

Background/Objectives:Few studies have used biomarkers of whole-grain intake to study its relation to glucose metabolism. We aimed to investigate the association between plasma alkylresorcinols (AR), a biomarker of whole-grain rye and wheat intake, and glucose metabolism in individuals with metabolic syndrome (MetS).Subjects/Methods:Participants were 30-65 years of age, with body mass index 27-40 kg/m 2 and had MetS without diabetes. Individuals were recruited through six centers in the Nordic countries and randomized to a healthy Nordic diet (ND, n=96), rich in whole-grain rye and wheat, or a control diet (n=70), for 18-24 weeks. In addition, associations between total plasma AR concentration and C17:0/C21:0 homolog ratio as an indication of the relative whole-grain rye intake, and glucose metabolism measures from oral glucose tolerance tests were investigated in pooled (ND+control) regression analyses at 18/24 weeks.Results:ND did not improve glucose metabolism compared with control diet, but the AR C17:0/C21:0 ratio was inversely associated with fasting insulin concentrations (P=0.002) and positively associated with the insulin sensitivity indices Matsuda ISI (P=0.026) and disposition index (P=0.022) in pooled analyses at 18/24 weeks, even after adjustment for confounders. The AR C17:0/C21:0 ratio was not significantly associated with insulin secretion indices. Total plasma AR concentration was not related to fasting plasma glucose or fasting insulin at 18/24 weeks.Conclusions:The AR C17:0/C21:0 ratio, an indicator of relative whole-grain rye intake, is associated with increased insulin sensitivity in a population with MetS
Original languageEnglish
Pages (from-to)453-458
Number of pages5
JournalEuropean Journal of Clinical Nutrition
Volume68
Issue number4
DOIs
Publication statusPublished - 2014
MoE publication typeA1 Journal article-refereed

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Insulin Resistance
Biomarkers
Glucose
Fasting
Insulin
Triticum
Diet
Scandinavian and Nordic Countries
Glucose Tolerance Test
Body Mass Index
Regression Analysis
Whole Grains
Secale
Population

Keywords

  • Alkylresorcinols
  • insulin sensitivity
  • rye
  • whole grain

Cite this

Magnusdottir, O K ; Landberg, R ; Gunnarsdottir, I ; Cloetens, L ; Åkesson, B ; Landin-Olsson, M ; Rosqvist, F ; Iggman, D ; Schwab, U ; Herzig, K-H ; Savolainen, M J ; Brader, L ; Hermansen, K ; Kolehmainen, Marjukka ; Poutanen, Kaisa ; Uusitupa, M ; Thorsdottir, I ; Riserus, U. / Plasma alkylresorcinols C17:0/C21:0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity : a randomized study. In: European Journal of Clinical Nutrition. 2014 ; Vol. 68, No. 4. pp. 453-458.
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title = "Plasma alkylresorcinols C17:0/C21:0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity: a randomized study",
abstract = "Background/Objectives:Few studies have used biomarkers of whole-grain intake to study its relation to glucose metabolism. We aimed to investigate the association between plasma alkylresorcinols (AR), a biomarker of whole-grain rye and wheat intake, and glucose metabolism in individuals with metabolic syndrome (MetS).Subjects/Methods:Participants were 30-65 years of age, with body mass index 27-40 kg/m 2 and had MetS without diabetes. Individuals were recruited through six centers in the Nordic countries and randomized to a healthy Nordic diet (ND, n=96), rich in whole-grain rye and wheat, or a control diet (n=70), for 18-24 weeks. In addition, associations between total plasma AR concentration and C17:0/C21:0 homolog ratio as an indication of the relative whole-grain rye intake, and glucose metabolism measures from oral glucose tolerance tests were investigated in pooled (ND+control) regression analyses at 18/24 weeks.Results:ND did not improve glucose metabolism compared with control diet, but the AR C17:0/C21:0 ratio was inversely associated with fasting insulin concentrations (P=0.002) and positively associated with the insulin sensitivity indices Matsuda ISI (P=0.026) and disposition index (P=0.022) in pooled analyses at 18/24 weeks, even after adjustment for confounders. The AR C17:0/C21:0 ratio was not significantly associated with insulin secretion indices. Total plasma AR concentration was not related to fasting plasma glucose or fasting insulin at 18/24 weeks.Conclusions:The AR C17:0/C21:0 ratio, an indicator of relative whole-grain rye intake, is associated with increased insulin sensitivity in a population with MetS",
keywords = "Alkylresorcinols, insulin sensitivity, rye, whole grain",
author = "Magnusdottir, {O K} and R Landberg and I Gunnarsdottir and L Cloetens and B {\AA}kesson and M Landin-Olsson and F Rosqvist and D Iggman and U Schwab and K-H Herzig and Savolainen, {M J} and L Brader and K Hermansen and Marjukka Kolehmainen and Kaisa Poutanen and M Uusitupa and I Thorsdottir and U Riserus",
year = "2014",
doi = "10.1038/ejcn.2014.12",
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pages = "453--458",
journal = "European Journal of Clinical Nutrition",
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Magnusdottir, OK, Landberg, R, Gunnarsdottir, I, Cloetens, L, Åkesson, B, Landin-Olsson, M, Rosqvist, F, Iggman, D, Schwab, U, Herzig, K-H, Savolainen, MJ, Brader, L, Hermansen, K, Kolehmainen, M, Poutanen, K, Uusitupa, M, Thorsdottir, I & Riserus, U 2014, 'Plasma alkylresorcinols C17:0/C21:0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity: a randomized study', European Journal of Clinical Nutrition, vol. 68, no. 4, pp. 453-458. https://doi.org/10.1038/ejcn.2014.12

Plasma alkylresorcinols C17:0/C21:0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity : a randomized study. / Magnusdottir, O K (Corresponding Author); Landberg, R; Gunnarsdottir, I; Cloetens, L; Åkesson, B; Landin-Olsson, M; Rosqvist, F; Iggman, D; Schwab, U; Herzig, K-H; Savolainen, M J; Brader, L; Hermansen, K; Kolehmainen, Marjukka; Poutanen, Kaisa; Uusitupa, M; Thorsdottir, I; Riserus, U.

In: European Journal of Clinical Nutrition, Vol. 68, No. 4, 2014, p. 453-458.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Plasma alkylresorcinols C17:0/C21:0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity

T2 - a randomized study

AU - Magnusdottir, O K

AU - Landberg, R

AU - Gunnarsdottir, I

AU - Cloetens, L

AU - Åkesson, B

AU - Landin-Olsson, M

AU - Rosqvist, F

AU - Iggman, D

AU - Schwab, U

AU - Herzig, K-H

AU - Savolainen, M J

AU - Brader, L

AU - Hermansen, K

AU - Kolehmainen, Marjukka

AU - Poutanen, Kaisa

AU - Uusitupa, M

AU - Thorsdottir, I

AU - Riserus, U

PY - 2014

Y1 - 2014

N2 - Background/Objectives:Few studies have used biomarkers of whole-grain intake to study its relation to glucose metabolism. We aimed to investigate the association between plasma alkylresorcinols (AR), a biomarker of whole-grain rye and wheat intake, and glucose metabolism in individuals with metabolic syndrome (MetS).Subjects/Methods:Participants were 30-65 years of age, with body mass index 27-40 kg/m 2 and had MetS without diabetes. Individuals were recruited through six centers in the Nordic countries and randomized to a healthy Nordic diet (ND, n=96), rich in whole-grain rye and wheat, or a control diet (n=70), for 18-24 weeks. In addition, associations between total plasma AR concentration and C17:0/C21:0 homolog ratio as an indication of the relative whole-grain rye intake, and glucose metabolism measures from oral glucose tolerance tests were investigated in pooled (ND+control) regression analyses at 18/24 weeks.Results:ND did not improve glucose metabolism compared with control diet, but the AR C17:0/C21:0 ratio was inversely associated with fasting insulin concentrations (P=0.002) and positively associated with the insulin sensitivity indices Matsuda ISI (P=0.026) and disposition index (P=0.022) in pooled analyses at 18/24 weeks, even after adjustment for confounders. The AR C17:0/C21:0 ratio was not significantly associated with insulin secretion indices. Total plasma AR concentration was not related to fasting plasma glucose or fasting insulin at 18/24 weeks.Conclusions:The AR C17:0/C21:0 ratio, an indicator of relative whole-grain rye intake, is associated with increased insulin sensitivity in a population with MetS

AB - Background/Objectives:Few studies have used biomarkers of whole-grain intake to study its relation to glucose metabolism. We aimed to investigate the association between plasma alkylresorcinols (AR), a biomarker of whole-grain rye and wheat intake, and glucose metabolism in individuals with metabolic syndrome (MetS).Subjects/Methods:Participants were 30-65 years of age, with body mass index 27-40 kg/m 2 and had MetS without diabetes. Individuals were recruited through six centers in the Nordic countries and randomized to a healthy Nordic diet (ND, n=96), rich in whole-grain rye and wheat, or a control diet (n=70), for 18-24 weeks. In addition, associations between total plasma AR concentration and C17:0/C21:0 homolog ratio as an indication of the relative whole-grain rye intake, and glucose metabolism measures from oral glucose tolerance tests were investigated in pooled (ND+control) regression analyses at 18/24 weeks.Results:ND did not improve glucose metabolism compared with control diet, but the AR C17:0/C21:0 ratio was inversely associated with fasting insulin concentrations (P=0.002) and positively associated with the insulin sensitivity indices Matsuda ISI (P=0.026) and disposition index (P=0.022) in pooled analyses at 18/24 weeks, even after adjustment for confounders. The AR C17:0/C21:0 ratio was not significantly associated with insulin secretion indices. Total plasma AR concentration was not related to fasting plasma glucose or fasting insulin at 18/24 weeks.Conclusions:The AR C17:0/C21:0 ratio, an indicator of relative whole-grain rye intake, is associated with increased insulin sensitivity in a population with MetS

KW - Alkylresorcinols

KW - insulin sensitivity

KW - rye

KW - whole grain

U2 - 10.1038/ejcn.2014.12

DO - 10.1038/ejcn.2014.12

M3 - Article

VL - 68

SP - 453

EP - 458

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

SN - 0954-3007

IS - 4

ER -