Plasma alkylresorcinols C17:0/C21:0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity: a randomized study

O K Magnusdottir (Corresponding Author), R Landberg, I Gunnarsdottir, L Cloetens, B Åkesson, M Landin-Olsson, F Rosqvist, D Iggman, U Schwab, K-H Herzig, M J Savolainen, L Brader, K Hermansen, Marjukka Kolehmainen, Kaisa Poutanen, M Uusitupa, I Thorsdottir, U Riserus

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Abstract

Background/Objectives:Few studies have used biomarkers of whole-grain intake to study its relation to glucose metabolism. We aimed to investigate the association between plasma alkylresorcinols (AR), a biomarker of whole-grain rye and wheat intake, and glucose metabolism in individuals with metabolic syndrome (MetS).Subjects/Methods:Participants were 30-65 years of age, with body mass index 27-40 kg/m 2 and had MetS without diabetes. Individuals were recruited through six centers in the Nordic countries and randomized to a healthy Nordic diet (ND, n=96), rich in whole-grain rye and wheat, or a control diet (n=70), for 18-24 weeks. In addition, associations between total plasma AR concentration and C17:0/C21:0 homolog ratio as an indication of the relative whole-grain rye intake, and glucose metabolism measures from oral glucose tolerance tests were investigated in pooled (ND+control) regression analyses at 18/24 weeks.Results:ND did not improve glucose metabolism compared with control diet, but the AR C17:0/C21:0 ratio was inversely associated with fasting insulin concentrations (P=0.002) and positively associated with the insulin sensitivity indices Matsuda ISI (P=0.026) and disposition index (P=0.022) in pooled analyses at 18/24 weeks, even after adjustment for confounders. The AR C17:0/C21:0 ratio was not significantly associated with insulin secretion indices. Total plasma AR concentration was not related to fasting plasma glucose or fasting insulin at 18/24 weeks.Conclusions:The AR C17:0/C21:0 ratio, an indicator of relative whole-grain rye intake, is associated with increased insulin sensitivity in a population with MetS
Original languageEnglish
Pages (from-to)453-458
Number of pages5
JournalEuropean Journal of Clinical Nutrition
Volume68
Issue number4
DOIs
Publication statusPublished - 2014
MoE publication typeA1 Journal article-refereed

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Keywords

  • Alkylresorcinols
  • insulin sensitivity
  • rye
  • whole grain

Cite this

Magnusdottir, O. K., Landberg, R., Gunnarsdottir, I., Cloetens, L., Åkesson, B., Landin-Olsson, M., Rosqvist, F., Iggman, D., Schwab, U., Herzig, K-H., Savolainen, M. J., Brader, L., Hermansen, K., Kolehmainen, M., Poutanen, K., Uusitupa, M., Thorsdottir, I., & Riserus, U. (2014). Plasma alkylresorcinols C17:0/C21:0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity: a randomized study. European Journal of Clinical Nutrition, 68(4), 453-458. https://doi.org/10.1038/ejcn.2014.12