TY - JOUR
T1 - Plasma alkylresorcinols C17:0/C21:0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity
T2 - a randomized study
AU - Magnusdottir, O K
AU - Landberg, R
AU - Gunnarsdottir, I
AU - Cloetens, L
AU - Åkesson, B
AU - Landin-Olsson, M
AU - Rosqvist, F
AU - Iggman, D
AU - Schwab, U
AU - Herzig, K-H
AU - Savolainen, M J
AU - Brader, L
AU - Hermansen, K
AU - Kolehmainen, Marjukka
AU - Poutanen, Kaisa
AU - Uusitupa, M
AU - Thorsdottir, I
AU - Riserus, U
PY - 2014
Y1 - 2014
N2 - Background/Objectives:Few studies have used biomarkers of
whole-grain intake to study its relation to glucose
metabolism. We aimed to investigate the association
between plasma alkylresorcinols (AR), a biomarker of
whole-grain rye and wheat intake, and glucose metabolism
in individuals with metabolic syndrome
(MetS).Subjects/Methods:Participants were 30-65 years of
age, with body mass index 27-40 kg/m 2 and had MetS
without diabetes. Individuals were recruited through six
centers in the Nordic countries and randomized to a
healthy Nordic diet (ND, n=96), rich in whole-grain rye
and wheat, or a control diet (n=70), for 18-24 weeks. In
addition, associations between total plasma AR
concentration and C17:0/C21:0 homolog ratio as an
indication of the relative whole-grain rye intake, and
glucose metabolism measures from oral glucose tolerance
tests were investigated in pooled (ND+control) regression
analyses at 18/24 weeks.Results:ND did not improve
glucose metabolism compared with control diet, but the AR
C17:0/C21:0 ratio was inversely associated with fasting
insulin concentrations (P=0.002) and positively
associated with the insulin sensitivity indices Matsuda
ISI (P=0.026) and disposition index (P=0.022) in pooled
analyses at 18/24 weeks, even after adjustment for
confounders. The AR C17:0/C21:0 ratio was not
significantly associated with insulin secretion indices.
Total plasma AR concentration was not related to fasting
plasma glucose or fasting insulin at 18/24
weeks.Conclusions:The AR C17:0/C21:0 ratio, an indicator
of relative whole-grain rye intake, is associated with
increased insulin sensitivity in a population with MetS
AB - Background/Objectives:Few studies have used biomarkers of
whole-grain intake to study its relation to glucose
metabolism. We aimed to investigate the association
between plasma alkylresorcinols (AR), a biomarker of
whole-grain rye and wheat intake, and glucose metabolism
in individuals with metabolic syndrome
(MetS).Subjects/Methods:Participants were 30-65 years of
age, with body mass index 27-40 kg/m 2 and had MetS
without diabetes. Individuals were recruited through six
centers in the Nordic countries and randomized to a
healthy Nordic diet (ND, n=96), rich in whole-grain rye
and wheat, or a control diet (n=70), for 18-24 weeks. In
addition, associations between total plasma AR
concentration and C17:0/C21:0 homolog ratio as an
indication of the relative whole-grain rye intake, and
glucose metabolism measures from oral glucose tolerance
tests were investigated in pooled (ND+control) regression
analyses at 18/24 weeks.Results:ND did not improve
glucose metabolism compared with control diet, but the AR
C17:0/C21:0 ratio was inversely associated with fasting
insulin concentrations (P=0.002) and positively
associated with the insulin sensitivity indices Matsuda
ISI (P=0.026) and disposition index (P=0.022) in pooled
analyses at 18/24 weeks, even after adjustment for
confounders. The AR C17:0/C21:0 ratio was not
significantly associated with insulin secretion indices.
Total plasma AR concentration was not related to fasting
plasma glucose or fasting insulin at 18/24
weeks.Conclusions:The AR C17:0/C21:0 ratio, an indicator
of relative whole-grain rye intake, is associated with
increased insulin sensitivity in a population with MetS
KW - Alkylresorcinols
KW - insulin sensitivity
KW - rye
KW - whole grain
U2 - 10.1038/ejcn.2014.12
DO - 10.1038/ejcn.2014.12
M3 - Article
SN - 0954-3007
VL - 68
SP - 453
EP - 458
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
IS - 4
ER -
