Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 453-458 |
| Number of pages | 5 |
| Journal | European Journal of Clinical Nutrition |
| Volume | 68 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2014 |
| MoE publication type | A1 Journal article-refereed |
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Keywords
- Alkylresorcinols
- insulin sensitivity
- rye
- whole grain
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Plasma alkylresorcinols C17:0/C21:0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity : a randomized study. / Magnusdottir, O K (Corresponding Author); Landberg, R; Gunnarsdottir, I; Cloetens, L; Åkesson, B; Landin-Olsson, M; Rosqvist, F; Iggman, D; Schwab, U; Herzig, K-H; Savolainen, M J; Brader, L; Hermansen, K; Kolehmainen, Marjukka; Poutanen, Kaisa; Uusitupa, M; Thorsdottir, I; Riserus, U.
In: European Journal of Clinical Nutrition, Vol. 68, No. 4, 2014, p. 453-458.Research output: Contribution to journal › Article › Scientific › peer-review
TY - JOUR
T1 - Plasma alkylresorcinols C17:0/C21:0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity
T2 - a randomized study
AU - Magnusdottir, O K
AU - Landberg, R
AU - Gunnarsdottir, I
AU - Cloetens, L
AU - Åkesson, B
AU - Landin-Olsson, M
AU - Rosqvist, F
AU - Iggman, D
AU - Schwab, U
AU - Herzig, K-H
AU - Savolainen, M J
AU - Brader, L
AU - Hermansen, K
AU - Kolehmainen, Marjukka
AU - Poutanen, Kaisa
AU - Uusitupa, M
AU - Thorsdottir, I
AU - Riserus, U
PY - 2014
Y1 - 2014
N2 - Background/Objectives:Few studies have used biomarkers of whole-grain intake to study its relation to glucose metabolism. We aimed to investigate the association between plasma alkylresorcinols (AR), a biomarker of whole-grain rye and wheat intake, and glucose metabolism in individuals with metabolic syndrome (MetS).Subjects/Methods:Participants were 30-65 years of age, with body mass index 27-40 kg/m 2 and had MetS without diabetes. Individuals were recruited through six centers in the Nordic countries and randomized to a healthy Nordic diet (ND, n=96), rich in whole-grain rye and wheat, or a control diet (n=70), for 18-24 weeks. In addition, associations between total plasma AR concentration and C17:0/C21:0 homolog ratio as an indication of the relative whole-grain rye intake, and glucose metabolism measures from oral glucose tolerance tests were investigated in pooled (ND+control) regression analyses at 18/24 weeks.Results:ND did not improve glucose metabolism compared with control diet, but the AR C17:0/C21:0 ratio was inversely associated with fasting insulin concentrations (P=0.002) and positively associated with the insulin sensitivity indices Matsuda ISI (P=0.026) and disposition index (P=0.022) in pooled analyses at 18/24 weeks, even after adjustment for confounders. The AR C17:0/C21:0 ratio was not significantly associated with insulin secretion indices. Total plasma AR concentration was not related to fasting plasma glucose or fasting insulin at 18/24 weeks.Conclusions:The AR C17:0/C21:0 ratio, an indicator of relative whole-grain rye intake, is associated with increased insulin sensitivity in a population with MetS
AB - Background/Objectives:Few studies have used biomarkers of whole-grain intake to study its relation to glucose metabolism. We aimed to investigate the association between plasma alkylresorcinols (AR), a biomarker of whole-grain rye and wheat intake, and glucose metabolism in individuals with metabolic syndrome (MetS).Subjects/Methods:Participants were 30-65 years of age, with body mass index 27-40 kg/m 2 and had MetS without diabetes. Individuals were recruited through six centers in the Nordic countries and randomized to a healthy Nordic diet (ND, n=96), rich in whole-grain rye and wheat, or a control diet (n=70), for 18-24 weeks. In addition, associations between total plasma AR concentration and C17:0/C21:0 homolog ratio as an indication of the relative whole-grain rye intake, and glucose metabolism measures from oral glucose tolerance tests were investigated in pooled (ND+control) regression analyses at 18/24 weeks.Results:ND did not improve glucose metabolism compared with control diet, but the AR C17:0/C21:0 ratio was inversely associated with fasting insulin concentrations (P=0.002) and positively associated with the insulin sensitivity indices Matsuda ISI (P=0.026) and disposition index (P=0.022) in pooled analyses at 18/24 weeks, even after adjustment for confounders. The AR C17:0/C21:0 ratio was not significantly associated with insulin secretion indices. Total plasma AR concentration was not related to fasting plasma glucose or fasting insulin at 18/24 weeks.Conclusions:The AR C17:0/C21:0 ratio, an indicator of relative whole-grain rye intake, is associated with increased insulin sensitivity in a population with MetS
KW - Alkylresorcinols
KW - insulin sensitivity
KW - rye
KW - whole grain
U2 - 10.1038/ejcn.2014.12
DO - 10.1038/ejcn.2014.12
M3 - Article
VL - 68
SP - 453
EP - 458
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
SN - 0954-3007
IS - 4
ER -