Plasma enterolactone or intestinal Bifidobacterium levels do not explain adenoma formation in multiple intestinal neoplasia (Min) mice fed with two different types of rye-bran fractions

S. Oikarinen (Corresponding Author), S. Heinonen, Sirpa Karppinen, Jaana Mättö, Herman Adlercreutz, Kaisa Poutanen, M. Mutanen

Research output: Contribution to journalArticleScientificpeer-review

17 Citations (Scopus)

Abstract

The study was designed to evaluate whether two types of rye-bran fractions result in distinct bifidogenic effect or enterolactone production in multiple intestinal neoplasia (Min) mice and whether these parameters are associated with intestinal tumorigenesis in this animal model. The experimental diets were a non-fibre diet (control), a rye-bran diet, and diets containing either the soluble extract or the insoluble fraction prepared from rye bran. The main result on adenoma formation in these experiments was the observation that the soluble extract increased number (P=0·012) and size (P=0·008) of adenomas in the distal small intestine when compared with the non-fibre group. All rye-supplemented diets supported similarly the in vivo growth of Bifidobacterium (108–109 colony forming units/g) in Min mice, whereas the non-fibre diet lowered intestinal Bifidobacterium below the level of detection. The results show that water solubility does not affect the bifidogenicity of rye bran. Mean plasma enterolactone concentration was highest in the rye-bran group (30·0 nmol/l; P=0·002), which along with the soluble-extract group (16·2 nmol/l; P=0·024) differed significantly from the non-fibre diet group (7·5nmol/l). Thus, the mice fed with the rye bran were the best enterolactone producers. In conclusion, rye bran and rye fractions influence adenoma formation in Min mice to a varying degree but plasma enterolactone levels or the production of bifidogenic bacteria do not mediate the effect.
Original languageEnglish
Pages (from-to)119-125
Number of pages7
JournalBritish Journal of Nutrition
Volume90
Issue number1
DOIs
Publication statusPublished - 2003
MoE publication typeA1 Journal article-refereed

Fingerprint

Bifidobacterium
Adenoma
Diet
Neoplasms
2,3-bis(3'-hydroxybenzyl)butyrolactone
Secale
Solubility
Small Intestine
Carcinogenesis
Stem Cells
Animal Models
Bacteria
Water

Keywords

  • Min mice
  • Rye bran
  • Bifidobacterium
  • Lignans
  • Enterolactone

Cite this

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title = "Plasma enterolactone or intestinal Bifidobacterium levels do not explain adenoma formation in multiple intestinal neoplasia (Min) mice fed with two different types of rye-bran fractions",
abstract = "The study was designed to evaluate whether two types of rye-bran fractions result in distinct bifidogenic effect or enterolactone production in multiple intestinal neoplasia (Min) mice and whether these parameters are associated with intestinal tumorigenesis in this animal model. The experimental diets were a non-fibre diet (control), a rye-bran diet, and diets containing either the soluble extract or the insoluble fraction prepared from rye bran. The main result on adenoma formation in these experiments was the observation that the soluble extract increased number (P=0·012) and size (P=0·008) of adenomas in the distal small intestine when compared with the non-fibre group. All rye-supplemented diets supported similarly the in vivo growth of Bifidobacterium (108–109 colony forming units/g) in Min mice, whereas the non-fibre diet lowered intestinal Bifidobacterium below the level of detection. The results show that water solubility does not affect the bifidogenicity of rye bran. Mean plasma enterolactone concentration was highest in the rye-bran group (30·0 nmol/l; P=0·002), which along with the soluble-extract group (16·2 nmol/l; P=0·024) differed significantly from the non-fibre diet group (7·5nmol/l). Thus, the mice fed with the rye bran were the best enterolactone producers. In conclusion, rye bran and rye fractions influence adenoma formation in Min mice to a varying degree but plasma enterolactone levels or the production of bifidogenic bacteria do not mediate the effect.",
keywords = "Min mice, Rye bran, Bifidobacterium, Lignans, Enterolactone",
author = "S. Oikarinen and S. Heinonen and Sirpa Karppinen and Jaana M{\"a}tt{\"o} and Herman Adlercreutz and Kaisa Poutanen and M. Mutanen",
year = "2003",
doi = "10.1079/BJN2003883",
language = "English",
volume = "90",
pages = "119--125",
journal = "British Journal of Nutrition",
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publisher = "Cambridge University Press",
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}

Plasma enterolactone or intestinal Bifidobacterium levels do not explain adenoma formation in multiple intestinal neoplasia (Min) mice fed with two different types of rye-bran fractions. / Oikarinen, S. (Corresponding Author); Heinonen, S.; Karppinen, Sirpa; Mättö, Jaana; Adlercreutz, Herman; Poutanen, Kaisa; Mutanen, M.

In: British Journal of Nutrition, Vol. 90, No. 1, 2003, p. 119-125.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Plasma enterolactone or intestinal Bifidobacterium levels do not explain adenoma formation in multiple intestinal neoplasia (Min) mice fed with two different types of rye-bran fractions

AU - Oikarinen, S.

AU - Heinonen, S.

AU - Karppinen, Sirpa

AU - Mättö, Jaana

AU - Adlercreutz, Herman

AU - Poutanen, Kaisa

AU - Mutanen, M.

PY - 2003

Y1 - 2003

N2 - The study was designed to evaluate whether two types of rye-bran fractions result in distinct bifidogenic effect or enterolactone production in multiple intestinal neoplasia (Min) mice and whether these parameters are associated with intestinal tumorigenesis in this animal model. The experimental diets were a non-fibre diet (control), a rye-bran diet, and diets containing either the soluble extract or the insoluble fraction prepared from rye bran. The main result on adenoma formation in these experiments was the observation that the soluble extract increased number (P=0·012) and size (P=0·008) of adenomas in the distal small intestine when compared with the non-fibre group. All rye-supplemented diets supported similarly the in vivo growth of Bifidobacterium (108–109 colony forming units/g) in Min mice, whereas the non-fibre diet lowered intestinal Bifidobacterium below the level of detection. The results show that water solubility does not affect the bifidogenicity of rye bran. Mean plasma enterolactone concentration was highest in the rye-bran group (30·0 nmol/l; P=0·002), which along with the soluble-extract group (16·2 nmol/l; P=0·024) differed significantly from the non-fibre diet group (7·5nmol/l). Thus, the mice fed with the rye bran were the best enterolactone producers. In conclusion, rye bran and rye fractions influence adenoma formation in Min mice to a varying degree but plasma enterolactone levels or the production of bifidogenic bacteria do not mediate the effect.

AB - The study was designed to evaluate whether two types of rye-bran fractions result in distinct bifidogenic effect or enterolactone production in multiple intestinal neoplasia (Min) mice and whether these parameters are associated with intestinal tumorigenesis in this animal model. The experimental diets were a non-fibre diet (control), a rye-bran diet, and diets containing either the soluble extract or the insoluble fraction prepared from rye bran. The main result on adenoma formation in these experiments was the observation that the soluble extract increased number (P=0·012) and size (P=0·008) of adenomas in the distal small intestine when compared with the non-fibre group. All rye-supplemented diets supported similarly the in vivo growth of Bifidobacterium (108–109 colony forming units/g) in Min mice, whereas the non-fibre diet lowered intestinal Bifidobacterium below the level of detection. The results show that water solubility does not affect the bifidogenicity of rye bran. Mean plasma enterolactone concentration was highest in the rye-bran group (30·0 nmol/l; P=0·002), which along with the soluble-extract group (16·2 nmol/l; P=0·024) differed significantly from the non-fibre diet group (7·5nmol/l). Thus, the mice fed with the rye bran were the best enterolactone producers. In conclusion, rye bran and rye fractions influence adenoma formation in Min mice to a varying degree but plasma enterolactone levels or the production of bifidogenic bacteria do not mediate the effect.

KW - Min mice

KW - Rye bran

KW - Bifidobacterium

KW - Lignans

KW - Enterolactone

U2 - 10.1079/BJN2003883

DO - 10.1079/BJN2003883

M3 - Article

VL - 90

SP - 119

EP - 125

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

IS - 1

ER -