Plasmon-resonant gold nanoparticles with variable morphology as optical labels and drug carriers for cytological research

Olga Bibikova, Alexey Popov, Ilya Skovorodkin, Artur Prilepskyi, Timofey Pylaev, Alexander Bykov, Sergey Staroverov, Vladimir Bogatyrev, Valery Tuchin, Matti Kinnunen, Seppo Vainio, Krizstian Kordas, Nikolai Khlebtsov

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

Abstract

In this work, two types of nanocomposites, silica-coated nano-sea-urchins and silica-coated gold nanostars, were fabricated. CTAB-coated nano-sea-urchins with an average size of about 100 nm demonstrate an absorption peak near 600-700 nm and stability in aqueous suspension. CTAB was exchanged with m-PEG-SH by an intermediate PEG layer. A layer of silica was synthesized on the nano-sea-urchins surface with thickness of about 20 nm. Nanostars with an average size of about 60 nm with a number of thin sharp branches were fabricated and functionalized by PVP to improve their stability. PVP-coated nanostars were used in optical coherence tomography experiments to show their contrasting properties. After silica-coating, stable and monodispersed nanoparticles with silica shell thickness about 60 nm were obtained. Nontoxicity of the silica-coated nanostars at least until the concentration of nanoparticles about 400 μg/mL was showed by fluorescent cell viability assay using propidium iodide. Extinction coefficient of the gold nanostars and nanocomposites was estimated by a spectrophotometer system in collimated transmission regime.

Original languageEnglish
Title of host publicationNovel Biophotonic Techniques and Applications II
EditorsAlex Vitkin, Arjen Amelink
PublisherInternational Society for Optics and Photonics SPIE
Volume1
ISBN (Print)978-0-81949-650-8
DOIs
Publication statusPublished - 1 Jan 2013
MoE publication typeA4 Article in a conference publication
EventEuropean Conference on Biomedical Optics, ECBO 2013 - Munich, Germany
Duration: 12 May 201316 May 2013

Publication series

SeriesProgress in Biomedical Optics and Imaging
Number51
Volume14
ISSN1605-7422
SeriesProceedings of SPIE
Volume8801
ISSN0277-786X

Conference

ConferenceEuropean Conference on Biomedical Optics, ECBO 2013
CountryGermany
CityMunich
Period12/05/1316/05/13

Keywords

  • Hela cells
  • Imaging
  • Nano-sea-urchins
  • Nanocomposites
  • Nanostars
  • Optical coherence tomography
  • Optical properties
  • Plasmonic nanoparticles
  • Toxicity

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  • Cite this

    Bibikova, O., Popov, A., Skovorodkin, I., Prilepskyi, A., Pylaev, T., Bykov, A., Staroverov, S., Bogatyrev, V., Tuchin, V., Kinnunen, M., Vainio, S., Kordas, K., & Khlebtsov, N. (2013). Plasmon-resonant gold nanoparticles with variable morphology as optical labels and drug carriers for cytological research. In A. Vitkin, & A. Amelink (Eds.), Novel Biophotonic Techniques and Applications II (Vol. 1). [880102] International Society for Optics and Photonics SPIE. Progress in Biomedical Optics and Imaging, No. 51, Vol.. 14, Proceedings of SPIE, Vol.. 8801 https://doi.org/10.1117/12.2032547