Polyethylenimine-modified metal oxides for fabrication of packed capillary columns for capillary electrochromatography and capillary liquid chromatography

Susanne K. Wiedmer, Giovanni D'Orazio, Jan-Henrik Smått, Delphine Bourdin, Clara Baños-Pérez, Motolani Sakeye, Maarit Kivilompolo, Matias Kopperi, José Ruiz-Jiménez, Salvatore Fanali, Marja-Liisa Riekkola (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

5 Citations (Scopus)

Abstract

The need for novel packing materials in both capillary electrochromatography (CEC) and capillary liquid chromatography (CLC) is apparent and the development towards more selective, application-oriented chromatographic phases is under progress world-wide. In this study we have synthesized new polyethyleneimine (PEI) functionalized Mn2O3, SiO2, SnO2, and ZrO2 particles for the fabrication of packed capillary columns for CEC and CLC. The nanocasting approach was successful for the preparation of functionalized metal oxide materials with a controlled porosity and morphology. PEI functionalization was done using ethyleneimine monomers to create particles which are positively charged in aqueous solution below pH 9. This functionalization allowed the possibility to have both hydrophobic (due to its alkyl chain) and ionic interactions (due to positively charged amino groups) with selected compounds. For comparison aminopropyl-functionalized silica was also synthesized and tested. Both slurry pressure and electrokinetic packing procedures used gave similar results, but fast sedimentation of the material caused some problems during the packing. The high stability and wide pH range of PEI-functionalized SiO2 material, with potential for hydrophobic and electrostatic interactions, proved to be useful for the CEC and CLC separation of some model acidic and neutral compounds.
Original languageEnglish
Pages (from-to)5020-5029
JournalJournal of Chromatography A
Volume1218
Issue number30
DOIs
Publication statusPublished - 2011
MoE publication typeA1 Journal article-refereed

Fingerprint

Capillary Electrochromatography
Polyethyleneimine
Liquid chromatography
Liquid Chromatography
Oxides
Metals
Fabrication
Porosity
Coulomb interactions
Static Electricity
Hydrophobic and Hydrophilic Interactions
Sedimentation
Silicon Dioxide
Monomers
Pressure

Keywords

  • Capillary liquid chromatography
  • capillary electrochromatography
  • metal oxides
  • polyethyleneimine functionalized metal oxides
  • nanocasting
  • slurry packing

Cite this

Wiedmer, Susanne K. ; D'Orazio, Giovanni ; Smått, Jan-Henrik ; Bourdin, Delphine ; Baños-Pérez, Clara ; Sakeye, Motolani ; Kivilompolo, Maarit ; Kopperi, Matias ; Ruiz-Jiménez, José ; Fanali, Salvatore ; Riekkola, Marja-Liisa. / Polyethylenimine-modified metal oxides for fabrication of packed capillary columns for capillary electrochromatography and capillary liquid chromatography. In: Journal of Chromatography A. 2011 ; Vol. 1218, No. 30. pp. 5020-5029.
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abstract = "The need for novel packing materials in both capillary electrochromatography (CEC) and capillary liquid chromatography (CLC) is apparent and the development towards more selective, application-oriented chromatographic phases is under progress world-wide. In this study we have synthesized new polyethyleneimine (PEI) functionalized Mn2O3, SiO2, SnO2, and ZrO2 particles for the fabrication of packed capillary columns for CEC and CLC. The nanocasting approach was successful for the preparation of functionalized metal oxide materials with a controlled porosity and morphology. PEI functionalization was done using ethyleneimine monomers to create particles which are positively charged in aqueous solution below pH 9. This functionalization allowed the possibility to have both hydrophobic (due to its alkyl chain) and ionic interactions (due to positively charged amino groups) with selected compounds. For comparison aminopropyl-functionalized silica was also synthesized and tested. Both slurry pressure and electrokinetic packing procedures used gave similar results, but fast sedimentation of the material caused some problems during the packing. The high stability and wide pH range of PEI-functionalized SiO2 material, with potential for hydrophobic and electrostatic interactions, proved to be useful for the CEC and CLC separation of some model acidic and neutral compounds.",
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Wiedmer, SK, D'Orazio, G, Smått, J-H, Bourdin, D, Baños-Pérez, C, Sakeye, M, Kivilompolo, M, Kopperi, M, Ruiz-Jiménez, J, Fanali, S & Riekkola, M-L 2011, 'Polyethylenimine-modified metal oxides for fabrication of packed capillary columns for capillary electrochromatography and capillary liquid chromatography', Journal of Chromatography A, vol. 1218, no. 30, pp. 5020-5029. https://doi.org/10.1016/j.chroma.2010.12.071

Polyethylenimine-modified metal oxides for fabrication of packed capillary columns for capillary electrochromatography and capillary liquid chromatography. / Wiedmer, Susanne K.; D'Orazio, Giovanni; Smått, Jan-Henrik; Bourdin, Delphine; Baños-Pérez, Clara; Sakeye, Motolani; Kivilompolo, Maarit; Kopperi, Matias; Ruiz-Jiménez, José; Fanali, Salvatore; Riekkola, Marja-Liisa (Corresponding Author).

In: Journal of Chromatography A, Vol. 1218, No. 30, 2011, p. 5020-5029.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Polyethylenimine-modified metal oxides for fabrication of packed capillary columns for capillary electrochromatography and capillary liquid chromatography

AU - Wiedmer, Susanne K.

AU - D'Orazio, Giovanni

AU - Smått, Jan-Henrik

AU - Bourdin, Delphine

AU - Baños-Pérez, Clara

AU - Sakeye, Motolani

AU - Kivilompolo, Maarit

AU - Kopperi, Matias

AU - Ruiz-Jiménez, José

AU - Fanali, Salvatore

AU - Riekkola, Marja-Liisa

N1 - Part of special issue: Selected Papers from the 28th International Symposium on Chromatography

PY - 2011

Y1 - 2011

N2 - The need for novel packing materials in both capillary electrochromatography (CEC) and capillary liquid chromatography (CLC) is apparent and the development towards more selective, application-oriented chromatographic phases is under progress world-wide. In this study we have synthesized new polyethyleneimine (PEI) functionalized Mn2O3, SiO2, SnO2, and ZrO2 particles for the fabrication of packed capillary columns for CEC and CLC. The nanocasting approach was successful for the preparation of functionalized metal oxide materials with a controlled porosity and morphology. PEI functionalization was done using ethyleneimine monomers to create particles which are positively charged in aqueous solution below pH 9. This functionalization allowed the possibility to have both hydrophobic (due to its alkyl chain) and ionic interactions (due to positively charged amino groups) with selected compounds. For comparison aminopropyl-functionalized silica was also synthesized and tested. Both slurry pressure and electrokinetic packing procedures used gave similar results, but fast sedimentation of the material caused some problems during the packing. The high stability and wide pH range of PEI-functionalized SiO2 material, with potential for hydrophobic and electrostatic interactions, proved to be useful for the CEC and CLC separation of some model acidic and neutral compounds.

AB - The need for novel packing materials in both capillary electrochromatography (CEC) and capillary liquid chromatography (CLC) is apparent and the development towards more selective, application-oriented chromatographic phases is under progress world-wide. In this study we have synthesized new polyethyleneimine (PEI) functionalized Mn2O3, SiO2, SnO2, and ZrO2 particles for the fabrication of packed capillary columns for CEC and CLC. The nanocasting approach was successful for the preparation of functionalized metal oxide materials with a controlled porosity and morphology. PEI functionalization was done using ethyleneimine monomers to create particles which are positively charged in aqueous solution below pH 9. This functionalization allowed the possibility to have both hydrophobic (due to its alkyl chain) and ionic interactions (due to positively charged amino groups) with selected compounds. For comparison aminopropyl-functionalized silica was also synthesized and tested. Both slurry pressure and electrokinetic packing procedures used gave similar results, but fast sedimentation of the material caused some problems during the packing. The high stability and wide pH range of PEI-functionalized SiO2 material, with potential for hydrophobic and electrostatic interactions, proved to be useful for the CEC and CLC separation of some model acidic and neutral compounds.

KW - Capillary liquid chromatography

KW - capillary electrochromatography

KW - metal oxides

KW - polyethyleneimine functionalized metal oxides

KW - nanocasting

KW - slurry packing

U2 - 10.1016/j.chroma.2010.12.071

DO - 10.1016/j.chroma.2010.12.071

M3 - Article

VL - 1218

SP - 5020

EP - 5029

JO - Journal of Chromatography A

JF - Journal of Chromatography A

SN - 0021-9673

IS - 30

ER -