Polymeric drug nanoparticles prepared by an aerosol flow reactor method

Hannele Eerikäinen, Esko I. Kauppinen (Corresponding Author), Jarno Kansikas

Research output: Contribution to journalArticleScientificpeer-review

27 Citations (Scopus)

Abstract

Purpose. Our purpose was to study the possibility of using a novel method, namely, aerosol flow reactor method, for the preparation of drug-containing nanoparticles with varying amounts of drug and polymer. The physical properties of the prepared nanoparticles were analyzed.

Methods. The nanoparticle size distributions were measured using differential mobility analyzer. The structure of the prepared nanoparticles was assessed by x-ray diffraction, differential scanning calorimetry, and electron microscopy. Drug release from the nanoparticles was analyzed.

Results. The spherical particles produced showed a unimodal and lognormal size distribution, and the geometric number mean size of the nanoparticles could be varied between 90 and 200 nm. When the amount of drug in the polymeric matrix was small, the nanoparticles had a homogeneous, amorphous structure. Drug crystals were formed when the amount of drug was increased over the solubility limit of the drug into the polymer. The amounts of drug and polymer controlled the drug release from the nanoparticles.

Conclusions. The aerosol flow reactor method was found to be able to produce homogeneous amorphous matrix-type nanoparticles that can directly be collected as dry powder.

Original languageEnglish
Pages (from-to)136 - 143
Number of pages8
JournalPharmaceutical Research
Volume21
Issue number1
DOIs
Publication statusPublished - 2004
MoE publication typeA1 Journal article-refereed

Fingerprint

Aerosols
Nanoparticles
Pharmaceutical Preparations
Polymers
Drug Compounding
Differential Scanning Calorimetry
Powders
Solubility
Electron microscopy
Differential scanning calorimetry
Electron Microscopy
Physical properties
Diffraction
X-Rays
X rays
Crystals

Keywords

  • amorphous
  • eudragit
  • nanoparticles
  • nanospheres
  • polymers
  • aerosols
  • aerosol flow reactor method
  • drug release
  • drugs

Cite this

Eerikäinen, Hannele ; Kauppinen, Esko I. ; Kansikas, Jarno. / Polymeric drug nanoparticles prepared by an aerosol flow reactor method. In: Pharmaceutical Research. 2004 ; Vol. 21, No. 1. pp. 136 - 143.
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Polymeric drug nanoparticles prepared by an aerosol flow reactor method. / Eerikäinen, Hannele; Kauppinen, Esko I. (Corresponding Author); Kansikas, Jarno.

In: Pharmaceutical Research, Vol. 21, No. 1, 2004, p. 136 - 143.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Polymeric drug nanoparticles prepared by an aerosol flow reactor method

AU - Eerikäinen, Hannele

AU - Kauppinen, Esko I.

AU - Kansikas, Jarno

PY - 2004

Y1 - 2004

N2 - Purpose. Our purpose was to study the possibility of using a novel method, namely, aerosol flow reactor method, for the preparation of drug-containing nanoparticles with varying amounts of drug and polymer. The physical properties of the prepared nanoparticles were analyzed.Methods. The nanoparticle size distributions were measured using differential mobility analyzer. The structure of the prepared nanoparticles was assessed by x-ray diffraction, differential scanning calorimetry, and electron microscopy. Drug release from the nanoparticles was analyzed.Results. The spherical particles produced showed a unimodal and lognormal size distribution, and the geometric number mean size of the nanoparticles could be varied between 90 and 200 nm. When the amount of drug in the polymeric matrix was small, the nanoparticles had a homogeneous, amorphous structure. Drug crystals were formed when the amount of drug was increased over the solubility limit of the drug into the polymer. The amounts of drug and polymer controlled the drug release from the nanoparticles.Conclusions. The aerosol flow reactor method was found to be able to produce homogeneous amorphous matrix-type nanoparticles that can directly be collected as dry powder.

AB - Purpose. Our purpose was to study the possibility of using a novel method, namely, aerosol flow reactor method, for the preparation of drug-containing nanoparticles with varying amounts of drug and polymer. The physical properties of the prepared nanoparticles were analyzed.Methods. The nanoparticle size distributions were measured using differential mobility analyzer. The structure of the prepared nanoparticles was assessed by x-ray diffraction, differential scanning calorimetry, and electron microscopy. Drug release from the nanoparticles was analyzed.Results. The spherical particles produced showed a unimodal and lognormal size distribution, and the geometric number mean size of the nanoparticles could be varied between 90 and 200 nm. When the amount of drug in the polymeric matrix was small, the nanoparticles had a homogeneous, amorphous structure. Drug crystals were formed when the amount of drug was increased over the solubility limit of the drug into the polymer. The amounts of drug and polymer controlled the drug release from the nanoparticles.Conclusions. The aerosol flow reactor method was found to be able to produce homogeneous amorphous matrix-type nanoparticles that can directly be collected as dry powder.

KW - amorphous

KW - eudragit

KW - nanoparticles

KW - nanospheres

KW - polymers

KW - aerosols

KW - aerosol flow reactor method

KW - drug release

KW - drugs

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DO - 10.1023/B:PHAM.0000012161.58738.25

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JO - Pharmaceutical Research

JF - Pharmaceutical Research

SN - 0724-8741

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