Polymeric dual-slab waveguide interferometer for biochemical sensing applications

M. Wang (Corresponding Author), Sanna Uusitalo, Christina Liedert, Jussi Hiltunen, Leena Hakalahti, R. Myllylä

Research output: Contribution to journalArticleScientificpeer-review

15 Citations (Scopus)

Abstract

A polymer based dual-slab waveguide Young’s interferometer was demonstrated for biochemical sensing. Evanescent field is utilized for probing the binding events of biomolecules on the waveguide surface. Refractive index sensing in analyte and protein adsorption on the sensing surface were investigated with glucose de-ionized water solution and bovine serum albumin, immunoglobulin G solutions in phosphate buffered saline buffer. A detection limit of 10−5 RIU and 4  pg/mm2 was achieved for homogeneous and surface sensing, respectively. Also, the influence of water absorption inside the polymeric device on the measurement stability was evaluated. The results indicate that the waveguide polymer sensor fabricated with the spin coating technique can achieve a satisfactory sensitivity for homogeneous refractive index sensing and, as well, for monitoring molecular binding events on the surface.
Original languageEnglish
Pages (from-to)1886-1893
Number of pages7
JournalApplied Optics
Volume51
Issue number12
DOIs
Publication statusPublished - 2012
MoE publication typeA1 Journal article-refereed

Fingerprint

Interferometers
slabs
Waveguides
interferometers
waveguides
Refractive index
Evanescent fields
Coating techniques
Spin coating
Biomolecules
Water absorption
Polymers
refractivity
Glucose
Phosphates
polymers
Proteins
albumins
Adsorption
glucose

Cite this

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abstract = "A polymer based dual-slab waveguide Young’s interferometer was demonstrated for biochemical sensing. Evanescent field is utilized for probing the binding events of biomolecules on the waveguide surface. Refractive index sensing in analyte and protein adsorption on the sensing surface were investigated with glucose de-ionized water solution and bovine serum albumin, immunoglobulin G solutions in phosphate buffered saline buffer. A detection limit of 10−5 RIU and 4  pg/mm2 was achieved for homogeneous and surface sensing, respectively. Also, the influence of water absorption inside the polymeric device on the measurement stability was evaluated. The results indicate that the waveguide polymer sensor fabricated with the spin coating technique can achieve a satisfactory sensitivity for homogeneous refractive index sensing and, as well, for monitoring molecular binding events on the surface.",
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Polymeric dual-slab waveguide interferometer for biochemical sensing applications. / Wang, M. (Corresponding Author); Uusitalo, Sanna; Liedert, Christina; Hiltunen, Jussi; Hakalahti, Leena; Myllylä, R.

In: Applied Optics, Vol. 51, No. 12, 2012, p. 1886-1893.

Research output: Contribution to journalArticleScientificpeer-review

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T1 - Polymeric dual-slab waveguide interferometer for biochemical sensing applications

AU - Wang, M.

AU - Uusitalo, Sanna

AU - Liedert, Christina

AU - Hiltunen, Jussi

AU - Hakalahti, Leena

AU - Myllylä, R.

PY - 2012

Y1 - 2012

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AB - A polymer based dual-slab waveguide Young’s interferometer was demonstrated for biochemical sensing. Evanescent field is utilized for probing the binding events of biomolecules on the waveguide surface. Refractive index sensing in analyte and protein adsorption on the sensing surface were investigated with glucose de-ionized water solution and bovine serum albumin, immunoglobulin G solutions in phosphate buffered saline buffer. A detection limit of 10−5 RIU and 4  pg/mm2 was achieved for homogeneous and surface sensing, respectively. Also, the influence of water absorption inside the polymeric device on the measurement stability was evaluated. The results indicate that the waveguide polymer sensor fabricated with the spin coating technique can achieve a satisfactory sensitivity for homogeneous refractive index sensing and, as well, for monitoring molecular binding events on the surface.

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