Polymeric dual-slab waveguide interferometer for biochemical sensing applications

M. Wang (Corresponding Author), Sanna Uusitalo, Christina Liedert, Jussi Hiltunen, Leena Hakalahti, R. Myllylä

    Research output: Contribution to journalArticleScientificpeer-review

    17 Citations (Scopus)

    Abstract

    A polymer based dual-slab waveguide Young’s interferometer was demonstrated for biochemical sensing. Evanescent field is utilized for probing the binding events of biomolecules on the waveguide surface. Refractive index sensing in analyte and protein adsorption on the sensing surface were investigated with glucose de-ionized water solution and bovine serum albumin, immunoglobulin G solutions in phosphate buffered saline buffer. A detection limit of 10−5 RIU and 4  pg/mm2 was achieved for homogeneous and surface sensing, respectively. Also, the influence of water absorption inside the polymeric device on the measurement stability was evaluated. The results indicate that the waveguide polymer sensor fabricated with the spin coating technique can achieve a satisfactory sensitivity for homogeneous refractive index sensing and, as well, for monitoring molecular binding events on the surface.
    Original languageEnglish
    Pages (from-to)1886-1893
    Number of pages7
    JournalApplied Optics
    Volume51
    Issue number12
    DOIs
    Publication statusPublished - 2012
    MoE publication typeA1 Journal article-refereed

    Fingerprint

    Dive into the research topics of 'Polymeric dual-slab waveguide interferometer for biochemical sensing applications'. Together they form a unique fingerprint.

    Cite this