Abstract
| Original language | English |
|---|---|
| Article number | 065016 |
| Journal | Biomedical Materials |
| Volume | 10 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2015 |
| MoE publication type | A1 Journal article-refereed |
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Keywords
- absorbable screw
- biocompatibility
- in vivo
- osteointegration
- polypyrrole (PPy)
Cite this
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Polypyrrole coating on poly-(lactide/glycolide)-ß-tricalcium phosphate screws enhances new bone formation in rabbits. / Zhao, Ming-Dong; Björninen, Miina; Cao, Lu; Wang, Hui-Ren; Pelto, Jani; Li, Xiang-Qian; Hyttinen, Jari; Jiang, Yun-Qi; Kellomäki, Minna; Miettinen, Susanna; Sándor, George K.; Seppänen, Riitta; Haimi, Suvi; Dong, Jian.
In: Biomedical Materials, Vol. 10, No. 6, 065016, 2015.Research output: Contribution to journal › Article › Scientific › peer-review
TY - JOUR
T1 - Polypyrrole coating on poly-(lactide/glycolide)-ß-tricalcium phosphate screws enhances new bone formation in rabbits
AU - Zhao, Ming-Dong
AU - Björninen, Miina
AU - Cao, Lu
AU - Wang, Hui-Ren
AU - Pelto, Jani
AU - Li, Xiang-Qian
AU - Hyttinen, Jari
AU - Jiang, Yun-Qi
AU - Kellomäki, Minna
AU - Miettinen, Susanna
AU - Sándor, George K.
AU - Seppänen, Riitta
AU - Haimi, Suvi
AU - Dong, Jian
PY - 2015
Y1 - 2015
N2 - Polypyrrole (PPy) has gained interest as an implant material due to its multifunctional properties and its high compatibility with several cell and tissue types. For the first time, the biocompatibility and osteointegration of PPy coating, incorporated with chondroitin sulfate (CS), were studied in vivo by implanting PPy-coated bioabsorbable bone fixation composite screws of poly-(lactide/glycolide) copolymer (PLGA) and ß-tricalcium phosphate (TCP) into New Zealand white rabbits. Uncoated bioabsorbable polymer composite screws and commercially available stainless steel cortical screws were used as reference implants. The rabbits were euthanized 12 and 26 weeks after the implantation. The systemic effects were evaluated from food and water consumption, body weight, body temperature, clinical signs, blood samples, internal organ weights, and histological examination. Local effects were studied from bone tissue and surrounding soft tissue histology. New bone formation was evaluated by micro-computed tomography, tetracycline labeling and torsion tests. Torsion tests were performed in order to capture the peak value of the torsion force during the course of the screw's loosening. The coated screws induced significantly more bone formation than the uncoated screws. In addition, none of the implants induced any systemic or local toxicity. The results suggest that PPy is biocompatible with bone tissue and is a potential coating for enhancing osteointegration in orthopedic implants.
AB - Polypyrrole (PPy) has gained interest as an implant material due to its multifunctional properties and its high compatibility with several cell and tissue types. For the first time, the biocompatibility and osteointegration of PPy coating, incorporated with chondroitin sulfate (CS), were studied in vivo by implanting PPy-coated bioabsorbable bone fixation composite screws of poly-(lactide/glycolide) copolymer (PLGA) and ß-tricalcium phosphate (TCP) into New Zealand white rabbits. Uncoated bioabsorbable polymer composite screws and commercially available stainless steel cortical screws were used as reference implants. The rabbits were euthanized 12 and 26 weeks after the implantation. The systemic effects were evaluated from food and water consumption, body weight, body temperature, clinical signs, blood samples, internal organ weights, and histological examination. Local effects were studied from bone tissue and surrounding soft tissue histology. New bone formation was evaluated by micro-computed tomography, tetracycline labeling and torsion tests. Torsion tests were performed in order to capture the peak value of the torsion force during the course of the screw's loosening. The coated screws induced significantly more bone formation than the uncoated screws. In addition, none of the implants induced any systemic or local toxicity. The results suggest that PPy is biocompatible with bone tissue and is a potential coating for enhancing osteointegration in orthopedic implants.
KW - absorbable screw
KW - biocompatibility
KW - in vivo
KW - osteointegration
KW - polypyrrole (PPy)
U2 - 10.1088/1748-6041/10/6/065016
DO - 10.1088/1748-6041/10/6/065016
M3 - Article
VL - 10
JO - Biomedical Materials
JF - Biomedical Materials
SN - 1748-6041
IS - 6
M1 - 065016
ER -