Porous Enzymatic Membrane for Nanotextured Glucose Sweat Sensors with High Stability toward Reliable Noninvasive Health Monitoring

Yuanjing Lin, Mallika Bariya, Hnin Yin Yin Nyein, Liisa Kivimäki, Sanna Uusitalo, Elina Jansson, Wenbo Ji, Zhen Yuan, Tuomas Happonen, Christina Liedert, Jussi Hiltunen, Zhiyong Fan (Corresponding Author), Ali Javey (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Development of reliable glucose sensors for noninvasive monitoring without interruption or limiting users' mobility is highly desirable, especially for diabetes diagnostics, which requires routine/long-term monitoring. However, their applications are largely limited by the relatively poor stability. Herein, a porous membrane is synthesized for effective enzyme immobilization and it is robustly anchored to the modified nanotextured electrode solid contacts, so as to realize glucose sensors with significantly enhanced sensing stability and mechanical robustness. To the best of our knowledge, this is the first report of utilizing such nanoporous membranes for electrochemical sensor applications, which eliminates enzyme escape and provides a sufficient surface area for molecular/ion diffusion and interactions, thus ensuring the sustainable catalytic activities of the sensors and generating reliable measureable signals during noninvasive monitoring. The as-assembled nanostructured glucose sensors demonstrate reliable long-term stable monitoring with a minimal response drift for up to 20 h, which delivers a remarkable enhancement. Moreover, they can be integrated into a microfluidic sensing patch for noninvasive sweat glucose monitoring. The as-synthesized nanostructured glucose sensors with remarkable stability can inspire developments of various enzymatic biosensors for reliable noninvasive composition analysis and their ultimate applications in predictive clinical diagnostics, personalized health-care monitoring, and chronic diseases management.

Original languageEnglish
Article number1902521
JournalAdvanced Functional Materials
Volume29
Issue number33
Early online date17 Jun 2019
DOIs
Publication statusPublished - 15 Aug 2019
MoE publication typeA1 Journal article-refereed

Fingerprint

sweat
Glucose sensors
glucose
health
Health
membranes
Membranes
Monitoring
sensors
enzymes
solid electrodes
Enzyme immobilization
Electrochemical sensors
interruption
Medical problems
molecular ions
immobilization
Health care
bioinstrumentation
Microfluidics

Keywords

  • glucose sensor
  • nanotextured electrode
  • porous enzymatic membrane
  • stable and reliable noninvasive monitoring

Cite this

@article{652211f5e87a4e12bbf1ff05eb8c6e64,
title = "Porous Enzymatic Membrane for Nanotextured Glucose Sweat Sensors with High Stability toward Reliable Noninvasive Health Monitoring",
abstract = "Development of reliable glucose sensors for noninvasive monitoring without interruption or limiting users' mobility is highly desirable, especially for diabetes diagnostics, which requires routine/long-term monitoring. However, their applications are largely limited by the relatively poor stability. Herein, a porous membrane is synthesized for effective enzyme immobilization and it is robustly anchored to the modified nanotextured electrode solid contacts, so as to realize glucose sensors with significantly enhanced sensing stability and mechanical robustness. To the best of our knowledge, this is the first report of utilizing such nanoporous membranes for electrochemical sensor applications, which eliminates enzyme escape and provides a sufficient surface area for molecular/ion diffusion and interactions, thus ensuring the sustainable catalytic activities of the sensors and generating reliable measureable signals during noninvasive monitoring. The as-assembled nanostructured glucose sensors demonstrate reliable long-term stable monitoring with a minimal response drift for up to 20 h, which delivers a remarkable enhancement. Moreover, they can be integrated into a microfluidic sensing patch for noninvasive sweat glucose monitoring. The as-synthesized nanostructured glucose sensors with remarkable stability can inspire developments of various enzymatic biosensors for reliable noninvasive composition analysis and their ultimate applications in predictive clinical diagnostics, personalized health-care monitoring, and chronic diseases management.",
keywords = "glucose sensor, nanotextured electrode, porous enzymatic membrane, stable and reliable noninvasive monitoring",
author = "Yuanjing Lin and Mallika Bariya and Nyein, {Hnin Yin Yin} and Liisa Kivim{\"a}ki and Sanna Uusitalo and Elina Jansson and Wenbo Ji and Zhen Yuan and Tuomas Happonen and Christina Liedert and Jussi Hiltunen and Zhiyong Fan and Ali Javey",
year = "2019",
month = "8",
day = "15",
doi = "10.1002/adfm.201902521",
language = "English",
volume = "29",
journal = "Advanced Functional Materials",
issn = "1616-301X",
publisher = "Wiley",
number = "33",

}

Porous Enzymatic Membrane for Nanotextured Glucose Sweat Sensors with High Stability toward Reliable Noninvasive Health Monitoring. / Lin, Yuanjing; Bariya, Mallika; Nyein, Hnin Yin Yin; Kivimäki, Liisa; Uusitalo, Sanna; Jansson, Elina; Ji, Wenbo; Yuan, Zhen; Happonen, Tuomas; Liedert, Christina; Hiltunen, Jussi; Fan, Zhiyong (Corresponding Author); Javey, Ali (Corresponding Author).

In: Advanced Functional Materials, Vol. 29, No. 33, 1902521, 15.08.2019.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Porous Enzymatic Membrane for Nanotextured Glucose Sweat Sensors with High Stability toward Reliable Noninvasive Health Monitoring

AU - Lin, Yuanjing

AU - Bariya, Mallika

AU - Nyein, Hnin Yin Yin

AU - Kivimäki, Liisa

AU - Uusitalo, Sanna

AU - Jansson, Elina

AU - Ji, Wenbo

AU - Yuan, Zhen

AU - Happonen, Tuomas

AU - Liedert, Christina

AU - Hiltunen, Jussi

AU - Fan, Zhiyong

AU - Javey, Ali

PY - 2019/8/15

Y1 - 2019/8/15

N2 - Development of reliable glucose sensors for noninvasive monitoring without interruption or limiting users' mobility is highly desirable, especially for diabetes diagnostics, which requires routine/long-term monitoring. However, their applications are largely limited by the relatively poor stability. Herein, a porous membrane is synthesized for effective enzyme immobilization and it is robustly anchored to the modified nanotextured electrode solid contacts, so as to realize glucose sensors with significantly enhanced sensing stability and mechanical robustness. To the best of our knowledge, this is the first report of utilizing such nanoporous membranes for electrochemical sensor applications, which eliminates enzyme escape and provides a sufficient surface area for molecular/ion diffusion and interactions, thus ensuring the sustainable catalytic activities of the sensors and generating reliable measureable signals during noninvasive monitoring. The as-assembled nanostructured glucose sensors demonstrate reliable long-term stable monitoring with a minimal response drift for up to 20 h, which delivers a remarkable enhancement. Moreover, they can be integrated into a microfluidic sensing patch for noninvasive sweat glucose monitoring. The as-synthesized nanostructured glucose sensors with remarkable stability can inspire developments of various enzymatic biosensors for reliable noninvasive composition analysis and their ultimate applications in predictive clinical diagnostics, personalized health-care monitoring, and chronic diseases management.

AB - Development of reliable glucose sensors for noninvasive monitoring without interruption or limiting users' mobility is highly desirable, especially for diabetes diagnostics, which requires routine/long-term monitoring. However, their applications are largely limited by the relatively poor stability. Herein, a porous membrane is synthesized for effective enzyme immobilization and it is robustly anchored to the modified nanotextured electrode solid contacts, so as to realize glucose sensors with significantly enhanced sensing stability and mechanical robustness. To the best of our knowledge, this is the first report of utilizing such nanoporous membranes for electrochemical sensor applications, which eliminates enzyme escape and provides a sufficient surface area for molecular/ion diffusion and interactions, thus ensuring the sustainable catalytic activities of the sensors and generating reliable measureable signals during noninvasive monitoring. The as-assembled nanostructured glucose sensors demonstrate reliable long-term stable monitoring with a minimal response drift for up to 20 h, which delivers a remarkable enhancement. Moreover, they can be integrated into a microfluidic sensing patch for noninvasive sweat glucose monitoring. The as-synthesized nanostructured glucose sensors with remarkable stability can inspire developments of various enzymatic biosensors for reliable noninvasive composition analysis and their ultimate applications in predictive clinical diagnostics, personalized health-care monitoring, and chronic diseases management.

KW - glucose sensor

KW - nanotextured electrode

KW - porous enzymatic membrane

KW - stable and reliable noninvasive monitoring

UR - http://www.scopus.com/inward/record.url?scp=85068255943&partnerID=8YFLogxK

U2 - 10.1002/adfm.201902521

DO - 10.1002/adfm.201902521

M3 - Article

VL - 29

JO - Advanced Functional Materials

JF - Advanced Functional Materials

SN - 1616-301X

IS - 33

M1 - 1902521

ER -