Prediction of microbial metabolism of phytochemicals using an in vitro colon model

Anna-Marja Aura, Tuulikki Seppänen-Laakso, Catherine Bounsaythip, Matej Oresic, Kirsi-Marja Oksman-Caldentey

    Research output: Contribution to journalOther journal contributionScientific

    Abstract

    Human colon contains 1.5kg of microbiota, which actively takes part in the degradation and decomposition of the non-absorbable intake. Colonic microbiota changes by age, diet, intestinal diseases and medication causing intra-individual variation in the metabolite pool in addition to the inter-individual variation between subjects. However, a good correlation has been found for dietary phenolic microbial metabolites between the in vitro colon model1 and corresponding metabolite profiles from human body fluids. Traditional prediction of drug metabolism includes several in vitro test systems and animal trials. However, microbial metabolism in the colon is not generally used in the pre-clinical stage. To address these challenges, the developed batch in vitro colon mode can be coupled with an advanced metabolomics and bioinformatics platform that provide complementary pre-clinical data on the metabolites circulating in the human body.
    Original languageEnglish
    JournalPlanta Medica
    Volume72
    Issue number11
    DOIs
    Publication statusPublished - 2006
    MoE publication typeNot Eligible
    Event54th Annual Congress on Medicinal Plant Research - Helsinki, Finland
    Duration: 29 Aug 20062 Sep 2006

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