Preliminary characterization of neurotoxic cyanobacteria blooms and strains from Finland

Kaarina Sivonen, Kimmo Himberg, Raija Luukkainen, Seppo Niemelä, G. Poon, Geoffrey Codd

Research output: Contribution to journalArticleScientific

150 Citations (Scopus)

Abstract

Two hundred fifteen cyanobacteria bloom samples collected from different parts of Finland were studied, 35 of which proved to be neurotoxic.
Toxicity was determined by mouse bioassay. Anabaena species were present in all neurotoxic samples except one, in which Oscillatoria dominated. The presence of anatoxin‐a in the blooms and in the isolated strains was studied from freeze‐dried materials by gas chromatography/mass spectrometry. The simultaneous occurrence of neurotoxicity and hepatotoxicity in some samples was studied by high performance liquid chromatography and high performance thin layer chromatography.
Thirteen out of 30 bloom samples contained anatoxin‐a. In the remaining samples, neurotoxicity was caused by unknown toxin(s). Strains producing anatoxin‐a were isolated from the genera Anabaena, Aphanizomenon, Oscillatoria, and Cylindrospermum. Anatoxin‐a content of the blooms varied from 12 to 4360 μg/g freeze‐dried material.
Some strains were able to produce about three times as much anatoxin‐a as was detected in natural blooms.
Simultaneous occurrence of neurotoxicity and hepatotoxicity was found in some samples as well as atypical toxic responses in mouse bioassay.
Original languageEnglish
Pages (from-to)339-352
JournalToxicity Assessment
Volume4
Issue number3
DOIs
Publication statusPublished - 1989
MoE publication typeB1 Article in a scientific magazine

Fingerprint

Oscillatoria
Anabaena
Bioassay
Cyanobacteria
Finland
Biological Assay
cyanobacterium
Aphanizomenon
algal bloom
Thin layer chromatography
Poisons
High performance liquid chromatography
Thin Layer Chromatography
Gas chromatography
Gas Chromatography-Mass Spectrometry
Mass spectrometry
Toxicity
High Pressure Liquid Chromatography
bioassay
toxin

Cite this

Sivonen, K., Himberg, K., Luukkainen, R., Niemelä, S., Poon, G., & Codd, G. (1989). Preliminary characterization of neurotoxic cyanobacteria blooms and strains from Finland. Toxicity Assessment, 4(3), 339-352. https://doi.org/10.1002/tox.2540040310
Sivonen, Kaarina ; Himberg, Kimmo ; Luukkainen, Raija ; Niemelä, Seppo ; Poon, G. ; Codd, Geoffrey. / Preliminary characterization of neurotoxic cyanobacteria blooms and strains from Finland. In: Toxicity Assessment. 1989 ; Vol. 4, No. 3. pp. 339-352.
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Sivonen, K, Himberg, K, Luukkainen, R, Niemelä, S, Poon, G & Codd, G 1989, 'Preliminary characterization of neurotoxic cyanobacteria blooms and strains from Finland', Toxicity Assessment, vol. 4, no. 3, pp. 339-352. https://doi.org/10.1002/tox.2540040310

Preliminary characterization of neurotoxic cyanobacteria blooms and strains from Finland. / Sivonen, Kaarina; Himberg, Kimmo; Luukkainen, Raija; Niemelä, Seppo; Poon, G.; Codd, Geoffrey.

In: Toxicity Assessment, Vol. 4, No. 3, 1989, p. 339-352.

Research output: Contribution to journalArticleScientific

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AU - Codd, Geoffrey

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AB - Two hundred fifteen cyanobacteria bloom samples collected from different parts of Finland were studied, 35 of which proved to be neurotoxic. Toxicity was determined by mouse bioassay. Anabaena species were present in all neurotoxic samples except one, in which Oscillatoria dominated. The presence of anatoxin‐a in the blooms and in the isolated strains was studied from freeze‐dried materials by gas chromatography/mass spectrometry. The simultaneous occurrence of neurotoxicity and hepatotoxicity in some samples was studied by high performance liquid chromatography and high performance thin layer chromatography. Thirteen out of 30 bloom samples contained anatoxin‐a. In the remaining samples, neurotoxicity was caused by unknown toxin(s). Strains producing anatoxin‐a were isolated from the genera Anabaena, Aphanizomenon, Oscillatoria, and Cylindrospermum. Anatoxin‐a content of the blooms varied from 12 to 4360 μg/g freeze‐dried material. Some strains were able to produce about three times as much anatoxin‐a as was detected in natural blooms. Simultaneous occurrence of neurotoxicity and hepatotoxicity was found in some samples as well as atypical toxic responses in mouse bioassay.

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