Abstract
The preparation, characterization and application of a new stationary
phase derived from 1,4-cyclohexanedione and diethyl (+)-tartrate are
described. A suitable TADDOL for immobilization has been synthesized and
grafted to a γ-mercaptopropylsilylated silica gel. The resulting
modified stationary phase has been characterized and its ability to
separate enantiomers has been studied. While the free TADDOL in solution
was able to resolve a range of enantiomers, the resolving properties
were lost on immobilization. Solid state 13C CPMAS NMR of the new stationary phase was used to explain the lack of stereoselective recognition.
Original language | English |
---|---|
Pages (from-to) | 2258-2261 |
Journal | Tetrahedron Letters |
Volume | 51 |
Issue number | 17 |
DOIs | |
Publication status | Published - 2010 |
MoE publication type | A1 Journal article-refereed |