Prevalence of plastic additives in indoor air related to newly diagnosed asthma

K. Villberg, H. Mussalo-Rauhamaa, T. Haahtela, Kristina Saarela

Research output: Contribution to journalArticleScientificpeer-review

9 Citations (Scopus)


This paper presents a correlation between the certain plastic additives and newly diagnosed asthma. We studied this association by measuring the plastic additives in the indoor air of the homes of presenting patients at the Skin and Allergy hospitals, including old and new, clinically diagnosed cases of asthma and controls. A total of 465 people filled in a questionnaire that probed, for example, health complaints, illnesses, and perceived conditions of their home environment. Asthma was diagnosed in 19 patients, and had earlier been found in 31 people. Compounds commonly used in plastic flooring manufacture were found to be more prevalent and in higher concentrations in the homes of subjects having newly diagnosed asthma. When the indoor air concentration of one plastic additive (2,2,4-trimethyl-1, 3-pentanediol di-isobutyrate) was 10 μg/m3 or greater (in Toluene equivalent), the age and sex adjusted odds ratio of having new asthma was 2.844, 95% CI 1.035—7.813.
Original languageEnglish
Pages (from-to)455-459
JournalIndoor and Built Environment
Issue number5
Publication statusPublished - 2008
MoE publication typeA1 Journal article-refereed


  • 2,2,4-Trimethyl-1
  • 3-Pentanediol di-isobutyrate
  • Indoor air
  • Newly diagnosed asthma
  • Plastic additive


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