Printable and flexible macroporous organosilica film with high protein adsorption capacity

J.J. Heikkinen; Liisa Kivimäki; V.P. Hytönen; M.S. Kulomaa; O.E.O. Hormi

doi:10.1016/j.tsf.2011.09.041

Printable and flexible macroporous organosilica film with high protein adsorption capacity

J.J. Heikkinen, Liisa Kivimäki, V.P. Hytönen, M.S. Kulomaa, O.E.O. Hormi (Corresponding Author)

Research output: Contribution to journal › Article › Scientific › peer-review

3 Citations (Scopus)

Abstract

An approach for creating a flexible and macroporous silsesquioxane film using phase separation method is described. The porous film was prepared by a simple coating method where sol–gel solution containing polyacrylic acid (PAA) and 1,6-bis(trimethoxysilyl)hexane in water was applied on boehmite silica coated polymethylmethacrylate (PMMA) film. After drying, the water soluble PAA template was removed by washing the film with water revealing the porous film. With certain ratios of PAA and water, fully co-continuous pore system with open surface was obtained. Porous films with 3–4 μm thickness were found to be highly flexible. The biocompatibility of the porous film was tested by immobilizing a high affinity biotin-binding chimeric avidin (ChiAVD(I117Y)) into the porous matrix The porous film was found to adsorb higher amounts of functional chimeric avidin compared to the pure PMMA film or a boehmite silica coated PMMA film.

Original language	English
Pages (from-to)	1934-1937
Number of pages	4
Journal	Thin Solid Films
Volume	520
Issue number	6
DOIs	https://doi.org/10.1016/j.tsf.2011.09.041
Publication status	Published - 2012
MoE publication type	A1 Journal article-refereed

Keywords

Flexible coatings
phase separation
porous films
printable coatings
protein immobilization
sol-gel

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10.1016/j.tsf.2011.09.041

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title = "Printable and flexible macroporous organosilica film with high protein adsorption capacity",

abstract = "An approach for creating a flexible and macroporous silsesquioxane film using phase separation method is described. The porous film was prepared by a simple coating method where sol–gel solution containing polyacrylic acid (PAA) and 1,6-bis(trimethoxysilyl)hexane in water was applied on boehmite silica coated polymethylmethacrylate (PMMA) film. After drying, the water soluble PAA template was removed by washing the film with water revealing the porous film. With certain ratios of PAA and water, fully co-continuous pore system with open surface was obtained. Porous films with 3–4 μm thickness were found to be highly flexible. The biocompatibility of the porous film was tested by immobilizing a high affinity biotin-binding chimeric avidin (ChiAVD(I117Y)) into the porous matrix The porous film was found to adsorb higher amounts of functional chimeric avidin compared to the pure PMMA film or a boehmite silica coated PMMA film.",

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author = "J.J. Heikkinen and Liisa Kivim{\"a}ki and V.P. Hyt{\"o}nen and M.S. Kulomaa and O.E.O. Hormi",

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T1 - Printable and flexible macroporous organosilica film with high protein adsorption capacity

AU - Heikkinen, J.J.

AU - Kivimäki, Liisa

AU - Hytönen, V.P.

AU - Kulomaa, M.S.

AU - Hormi, O.E.O.

PY - 2012

Y1 - 2012

N2 - An approach for creating a flexible and macroporous silsesquioxane film using phase separation method is described. The porous film was prepared by a simple coating method where sol–gel solution containing polyacrylic acid (PAA) and 1,6-bis(trimethoxysilyl)hexane in water was applied on boehmite silica coated polymethylmethacrylate (PMMA) film. After drying, the water soluble PAA template was removed by washing the film with water revealing the porous film. With certain ratios of PAA and water, fully co-continuous pore system with open surface was obtained. Porous films with 3–4 μm thickness were found to be highly flexible. The biocompatibility of the porous film was tested by immobilizing a high affinity biotin-binding chimeric avidin (ChiAVD(I117Y)) into the porous matrix The porous film was found to adsorb higher amounts of functional chimeric avidin compared to the pure PMMA film or a boehmite silica coated PMMA film.

AB - An approach for creating a flexible and macroporous silsesquioxane film using phase separation method is described. The porous film was prepared by a simple coating method where sol–gel solution containing polyacrylic acid (PAA) and 1,6-bis(trimethoxysilyl)hexane in water was applied on boehmite silica coated polymethylmethacrylate (PMMA) film. After drying, the water soluble PAA template was removed by washing the film with water revealing the porous film. With certain ratios of PAA and water, fully co-continuous pore system with open surface was obtained. Porous films with 3–4 μm thickness were found to be highly flexible. The biocompatibility of the porous film was tested by immobilizing a high affinity biotin-binding chimeric avidin (ChiAVD(I117Y)) into the porous matrix The porous film was found to adsorb higher amounts of functional chimeric avidin compared to the pure PMMA film or a boehmite silica coated PMMA film.

KW - Flexible coatings

KW - phase separation

KW - porous films

KW - printable coatings

KW - protein immobilization

KW - sol-gel

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DO - 10.1016/j.tsf.2011.09.041

M3 - Article

SN - 0040-6090

VL - 520

SP - 1934

EP - 1937

JO - Thin Solid Films

JF - Thin Solid Films

IS - 6

ER -

Printable and flexible macroporous organosilica film with high protein adsorption capacity

Abstract

Keywords

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