Abstract
An approach for creating a flexible and macroporous silsesquioxane film using phase separation method is described. The porous film was prepared by a simple coating method where sol–gel solution containing polyacrylic acid (PAA) and 1,6-bis(trimethoxysilyl)hexane in water was applied on boehmite silica coated polymethylmethacrylate (PMMA) film. After drying, the water soluble PAA template was removed by washing the film with water revealing the porous film. With certain ratios of PAA and water, fully co-continuous pore system with open surface was obtained. Porous films with 3–4 μm thickness were found to be highly flexible. The biocompatibility of the porous film was tested by immobilizing a high affinity biotin-binding chimeric avidin (ChiAVD(I117Y)) into the porous matrix The porous film was found to adsorb higher amounts of functional chimeric avidin compared to the pure PMMA film or a boehmite silica coated PMMA film.
| Original language | English |
|---|---|
| Pages (from-to) | 1934-1937 |
| Journal | Thin Solid Films |
| Volume | 520 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2012 |
| MoE publication type | A1 Journal article-refereed |
Funding
This work was financially supported by Tekes - the Finnish Funding Agency for Technology and Innovation ( BioFace 40055/08). JJH thanks Faculty of Science at the University of Oulu and Oulu University Scholarship Foundation and MSK Pirkanmaa Hospital District for financial support.
Keywords
- Flexible coatings
- phase separation
- porous films
- printable coatings
- protein immobilization
- sol-gel