Probiotics: Towards demonstrating efficacy

Tiina Mattila-Sandholm (Corresponding Author), S. Blum, J.K. Collins, Ross Crittenden, Willem de Vos, C. Dunne, R. Fonden, G. Grenov, Erika Isolauri, B. Kiely, P. Marteau, L. Morelli, A. Ouwehand, R. Reniero, Maria Saarela, Seppo Salminen, M. Saxelin, E. Schiffrin, F. Shanahan, E. VaughanAtte von Wright

Research output: Contribution to journalReview Articlepeer-review

86 Citations (Scopus)


PROBDEMO, a multi-centre European research project, began in 1996 with the aim of demonstrating that probiotic micro-organisms can positively effect human health in rigorously conducted human clinical studies. These studies, now completed, have shown that some probiotics can influence the composition of the intestinal microbiota and modulate the host immune system with measurable benefits to health, including the control of atopic eczema in infants with food allergy. Considerable promise was also demonstrated for the use of selected probiotics in controlling inflammatory bowel disease, and infections in children and the elderly. The scientific approaches to selecting and evaluating probiotics that were demonstrated in the PROBDEMO project provide a model for food manufacturers to move further towards demonstrating efficacy for their probiotic products.
Original languageEnglish
Pages (from-to)393-399
Number of pages7
JournalTrends in Food Science and Technology
Issue number12
Publication statusPublished - 1999
MoE publication typeA2 Review article in a scientific journal

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