Probiotics

Towards demonstrating efficacy

Tiina Mattila-Sandholm (Corresponding Author), S. Blum, J.K. Collins, Ross Crittenden, Willem de Vos, C. Dunne, R. Fonden, G. Grenov, Erika Isolauri, B. Kiely, P. Marteau, L. Morelli, A. Ouwehand, R. Reniero, Maria Saarela, Seppo Salminen, M. Saxelin, E. Schiffrin, F. Shanahan, E. Vaughan & 1 others Atte von Wright

Research output: Contribution to journalReview ArticleScientificpeer-review

84 Citations (Scopus)

Abstract

PROBDEMO, a multi-centre European research project, began in 1996 with the aim of demonstrating that probiotic micro-organisms can positively effect human health in rigorously conducted human clinical studies. These studies, now completed, have shown that some probiotics can influence the composition of the intestinal microbiota and modulate the host immune system with measurable benefits to health, including the control of atopic eczema in infants with food allergy. Considerable promise was also demonstrated for the use of selected probiotics in controlling inflammatory bowel disease, and infections in children and the elderly. The scientific approaches to selecting and evaluating probiotics that were demonstrated in the PROBDEMO project provide a model for food manufacturers to move further towards demonstrating efficacy for their probiotic products.
Original languageEnglish
Pages (from-to)393-399
Number of pages7
JournalTrends in Food Science and Technology
Volume10
Issue number12
DOIs
Publication statusPublished - 1999
MoE publication typeA2 Review article in a scientific journal

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Probiotics
probiotics
Infant Food
food allergies
atopic dermatitis
Food Hypersensitivity
inflammatory bowel disease
Insurance Benefits
Atopic Dermatitis
research projects
Inflammatory Bowel Diseases
intestinal microorganisms
immune system
human health
food industry
clinical trials
Immune System
microorganisms
Food
Health

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Mattila-Sandholm, T., Blum, S., Collins, J. K., Crittenden, R., de Vos, W., Dunne, C., ... von Wright, A. (1999). Probiotics: Towards demonstrating efficacy. Trends in Food Science and Technology, 10(12), 393-399. https://doi.org/10.1016/S0924-2244(00)00029-7
Mattila-Sandholm, Tiina ; Blum, S. ; Collins, J.K. ; Crittenden, Ross ; de Vos, Willem ; Dunne, C. ; Fonden, R. ; Grenov, G. ; Isolauri, Erika ; Kiely, B. ; Marteau, P. ; Morelli, L. ; Ouwehand, A. ; Reniero, R. ; Saarela, Maria ; Salminen, Seppo ; Saxelin, M. ; Schiffrin, E. ; Shanahan, F. ; Vaughan, E. ; von Wright, Atte. / Probiotics : Towards demonstrating efficacy. In: Trends in Food Science and Technology. 1999 ; Vol. 10, No. 12. pp. 393-399.
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abstract = "PROBDEMO, a multi-centre European research project, began in 1996 with the aim of demonstrating that probiotic micro-organisms can positively effect human health in rigorously conducted human clinical studies. These studies, now completed, have shown that some probiotics can influence the composition of the intestinal microbiota and modulate the host immune system with measurable benefits to health, including the control of atopic eczema in infants with food allergy. Considerable promise was also demonstrated for the use of selected probiotics in controlling inflammatory bowel disease, and infections in children and the elderly. The scientific approaches to selecting and evaluating probiotics that were demonstrated in the PROBDEMO project provide a model for food manufacturers to move further towards demonstrating efficacy for their probiotic products.",
author = "Tiina Mattila-Sandholm and S. Blum and J.K. Collins and Ross Crittenden and {de Vos}, Willem and C. Dunne and R. Fonden and G. Grenov and Erika Isolauri and B. Kiely and P. Marteau and L. Morelli and A. Ouwehand and R. Reniero and Maria Saarela and Seppo Salminen and M. Saxelin and E. Schiffrin and F. Shanahan and E. Vaughan and {von Wright}, Atte",
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Mattila-Sandholm, T, Blum, S, Collins, JK, Crittenden, R, de Vos, W, Dunne, C, Fonden, R, Grenov, G, Isolauri, E, Kiely, B, Marteau, P, Morelli, L, Ouwehand, A, Reniero, R, Saarela, M, Salminen, S, Saxelin, M, Schiffrin, E, Shanahan, F, Vaughan, E & von Wright, A 1999, 'Probiotics: Towards demonstrating efficacy', Trends in Food Science and Technology, vol. 10, no. 12, pp. 393-399. https://doi.org/10.1016/S0924-2244(00)00029-7

Probiotics : Towards demonstrating efficacy. / Mattila-Sandholm, Tiina (Corresponding Author); Blum, S.; Collins, J.K.; Crittenden, Ross; de Vos, Willem; Dunne, C.; Fonden, R.; Grenov, G.; Isolauri, Erika; Kiely, B.; Marteau, P.; Morelli, L.; Ouwehand, A.; Reniero, R.; Saarela, Maria; Salminen, Seppo; Saxelin, M.; Schiffrin, E.; Shanahan, F.; Vaughan, E.; von Wright, Atte.

In: Trends in Food Science and Technology, Vol. 10, No. 12, 1999, p. 393-399.

Research output: Contribution to journalReview ArticleScientificpeer-review

TY - JOUR

T1 - Probiotics

T2 - Towards demonstrating efficacy

AU - Mattila-Sandholm, Tiina

AU - Blum, S.

AU - Collins, J.K.

AU - Crittenden, Ross

AU - de Vos, Willem

AU - Dunne, C.

AU - Fonden, R.

AU - Grenov, G.

AU - Isolauri, Erika

AU - Kiely, B.

AU - Marteau, P.

AU - Morelli, L.

AU - Ouwehand, A.

AU - Reniero, R.

AU - Saarela, Maria

AU - Salminen, Seppo

AU - Saxelin, M.

AU - Schiffrin, E.

AU - Shanahan, F.

AU - Vaughan, E.

AU - von Wright, Atte

PY - 1999

Y1 - 1999

N2 - PROBDEMO, a multi-centre European research project, began in 1996 with the aim of demonstrating that probiotic micro-organisms can positively effect human health in rigorously conducted human clinical studies. These studies, now completed, have shown that some probiotics can influence the composition of the intestinal microbiota and modulate the host immune system with measurable benefits to health, including the control of atopic eczema in infants with food allergy. Considerable promise was also demonstrated for the use of selected probiotics in controlling inflammatory bowel disease, and infections in children and the elderly. The scientific approaches to selecting and evaluating probiotics that were demonstrated in the PROBDEMO project provide a model for food manufacturers to move further towards demonstrating efficacy for their probiotic products.

AB - PROBDEMO, a multi-centre European research project, began in 1996 with the aim of demonstrating that probiotic micro-organisms can positively effect human health in rigorously conducted human clinical studies. These studies, now completed, have shown that some probiotics can influence the composition of the intestinal microbiota and modulate the host immune system with measurable benefits to health, including the control of atopic eczema in infants with food allergy. Considerable promise was also demonstrated for the use of selected probiotics in controlling inflammatory bowel disease, and infections in children and the elderly. The scientific approaches to selecting and evaluating probiotics that were demonstrated in the PROBDEMO project provide a model for food manufacturers to move further towards demonstrating efficacy for their probiotic products.

U2 - 10.1016/S0924-2244(00)00029-7

DO - 10.1016/S0924-2244(00)00029-7

M3 - Review Article

VL - 10

SP - 393

EP - 399

JO - Trends in Food Science and Technology

JF - Trends in Food Science and Technology

SN - 0924-2244

IS - 12

ER -

Mattila-Sandholm T, Blum S, Collins JK, Crittenden R, de Vos W, Dunne C et al. Probiotics: Towards demonstrating efficacy. Trends in Food Science and Technology. 1999;10(12):393-399. https://doi.org/10.1016/S0924-2244(00)00029-7