Probiotics: Towards demonstrating efficacy

Tiina Mattila-Sandholm (Corresponding Author), S. Blum, J.K. Collins, Ross Crittenden, Willem de Vos, C. Dunne, R. Fonden, G. Grenov, Erika Isolauri, B. Kiely, P. Marteau, L. Morelli, A. Ouwehand, R. Reniero, Maria Saarela, Seppo Salminen, M. Saxelin, E. Schiffrin, F. Shanahan, E. VaughanAtte von Wright

    Research output: Contribution to journalReview Articlepeer-review

    90 Citations (Scopus)


    PROBDEMO, a multi-centre European research project, began in 1996 with the aim of demonstrating that probiotic micro-organisms can positively effect human health in rigorously conducted human clinical studies. These studies, now completed, have shown that some probiotics can influence the composition of the intestinal microbiota and modulate the host immune system with measurable benefits to health, including the control of atopic eczema in infants with food allergy. Considerable promise was also demonstrated for the use of selected probiotics in controlling inflammatory bowel disease, and infections in children and the elderly. The scientific approaches to selecting and evaluating probiotics that were demonstrated in the PROBDEMO project provide a model for food manufacturers to move further towards demonstrating efficacy for their probiotic products.
    Original languageEnglish
    Pages (from-to)393-399
    Number of pages7
    JournalTrends in Food Science and Technology
    Issue number12
    Publication statusPublished - 1999
    MoE publication typeA2 Review article in a scientific journal


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