TY - JOUR
T1 - Probiotics
T2 - Towards demonstrating efficacy
AU - Mattila-Sandholm, Tiina
AU - Blum, S.
AU - Collins, J.K.
AU - Crittenden, Ross
AU - de Vos, Willem
AU - Dunne, C.
AU - Fonden, R.
AU - Grenov, G.
AU - Isolauri, Erika
AU - Kiely, B.
AU - Marteau, P.
AU - Morelli, L.
AU - Ouwehand, A.
AU - Reniero, R.
AU - Saarela, Maria
AU - Salminen, Seppo
AU - Saxelin, M.
AU - Schiffrin, E.
AU - Shanahan, F.
AU - Vaughan, E.
AU - von Wright, Atte
PY - 1999
Y1 - 1999
N2 - PROBDEMO, a multi-centre European research project, began in 1996 with the aim of demonstrating that probiotic micro-organisms can positively effect human health in rigorously conducted human clinical studies. These studies, now completed, have shown that some probiotics can influence the composition of the intestinal microbiota and modulate the host immune system with measurable benefits to health, including the control of atopic eczema in infants with food allergy. Considerable promise was also demonstrated for the use of selected probiotics in controlling inflammatory bowel disease, and infections in children and the elderly. The scientific approaches to selecting and evaluating probiotics that were demonstrated in the PROBDEMO project provide a model for food manufacturers to move further towards demonstrating efficacy for their probiotic products.
AB - PROBDEMO, a multi-centre European research project, began in 1996 with the aim of demonstrating that probiotic micro-organisms can positively effect human health in rigorously conducted human clinical studies. These studies, now completed, have shown that some probiotics can influence the composition of the intestinal microbiota and modulate the host immune system with measurable benefits to health, including the control of atopic eczema in infants with food allergy. Considerable promise was also demonstrated for the use of selected probiotics in controlling inflammatory bowel disease, and infections in children and the elderly. The scientific approaches to selecting and evaluating probiotics that were demonstrated in the PROBDEMO project provide a model for food manufacturers to move further towards demonstrating efficacy for their probiotic products.
U2 - 10.1016/S0924-2244(00)00029-7
DO - 10.1016/S0924-2244(00)00029-7
M3 - Review Article
SN - 0924-2244
VL - 10
SP - 393
EP - 399
JO - Trends in Food Science and Technology
JF - Trends in Food Science and Technology
IS - 12
ER -