Probiotics: Towards demonstrating efficacy

Tiina Mattila-Sandholm; S. Blum; J.K. Collins; Ross Crittenden; Willem de Vos; C. Dunne; R. Fondén; G. Grenov; Erika Isolauri; B. Kiely; P. Marteau; L. Morelli; A. Ouwehand; R. Reniero; Maria Saarela; Seppo Salminen; M. Saxelin; E. Schiffrin; F. Shanahan; E. Vaughan; Atte von Wright

doi:10.1016/S0924-2244(00)00029-7

Probiotics: Towards demonstrating efficacy

Tiina Mattila-Sandholm^*
, S. Blum
, J.K. Collins
, Ross Crittenden
, Willem de Vos
, C. Dunne
, R. Fondén
, G. Grenov
, Erika Isolauri
, B. Kiely
, P. Marteau
, L. Morelli
, A. Ouwehand
, R. Reniero
, Maria Saarela
, Seppo Salminen
, M. Saxelin
, E. Schiffrin
, F. Shanahan
, E. Vaughan

Atte von Wright

^*Corresponding author for this work

University of Eastern Finland
VTT (former employee or external)
Nestec SA
University College Cork
Wageningen University & Research (WUR)
Arla R&D
Chr. Hansen A/S
Georges-Pompidou European Hospital
Turku University Hospital
Catholic University of Sacred Heart
University of Turku
Valio Oy

Research output: Contribution to journal › Review Article › peer-review

90 Citations (Scopus)

Abstract

PROBDEMO, a multi-centre European research project, began in 1996 with the aim of demonstrating that probiotic micro-organisms can positively effect human health in rigorously conducted human clinical studies. These studies, now completed, have shown that some probiotics can influence the composition of the intestinal microbiota and modulate the host immune system with measurable benefits to health, including the control of atopic eczema in infants with food allergy. Considerable promise was also demonstrated for the use of selected probiotics in controlling inflammatory bowel disease, and infections in children and the elderly. The scientific approaches to selecting and evaluating probiotics that were demonstrated in the PROBDEMO project provide a model for food manufacturers to move further towards demonstrating efficacy for their probiotic products.

Original language	English
Pages (from-to)	393-399
Journal	Trends in Food Science and Technology
Volume	10
Issue number	12
DOIs	https://doi.org/10.1016/S0924-2244(00)00029-7
Publication status	Published - 1999
MoE publication type	A2 Review article in a scientific journal

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10.1016/S0924-2244(00)00029-7

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Mattila-Sandholm, T., Blum, S., Collins, J. K., Crittenden, R., de Vos, W., Dunne, C., Fondén, R., Grenov, G., Isolauri, E., Kiely, B., Marteau, P., Morelli, L., Ouwehand, A., Reniero, R., Saarela, M., Salminen, S., Saxelin, M., Schiffrin, E., Shanahan, F., ... von Wright, A. (1999). Probiotics: Towards demonstrating efficacy. Trends in Food Science and Technology, 10(12), 393-399. https://doi.org/10.1016/S0924-2244(00)00029-7

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title = "Probiotics: Towards demonstrating efficacy",

abstract = "PROBDEMO, a multi-centre European research project, began in 1996 with the aim of demonstrating that probiotic micro-organisms can positively effect human health in rigorously conducted human clinical studies. These studies, now completed, have shown that some probiotics can influence the composition of the intestinal microbiota and modulate the host immune system with measurable benefits to health, including the control of atopic eczema in infants with food allergy. Considerable promise was also demonstrated for the use of selected probiotics in controlling inflammatory bowel disease, and infections in children and the elderly. The scientific approaches to selecting and evaluating probiotics that were demonstrated in the PROBDEMO project provide a model for food manufacturers to move further towards demonstrating efficacy for their probiotic products.",

author = "Tiina Mattila-Sandholm and S. Blum and J.K. Collins and Ross Crittenden and \{de Vos\}, Willem and C. Dunne and R. Fond{\'e}n and G. Grenov and Erika Isolauri and B. Kiely and P. Marteau and L. Morelli and A. Ouwehand and R. Reniero and Maria Saarela and Seppo Salminen and M. Saxelin and E. Schiffrin and F. Shanahan and E. Vaughan and \{von Wright\}, Atte",

year = "1999",

doi = "10.1016/S0924-2244(00)00029-7",

language = "English",

volume = "10",

pages = "393--399",

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Mattila-Sandholm, T, Blum, S, Collins, JK, Crittenden, R, de Vos, W, Dunne, C, Fondén, R, Grenov, G, Isolauri, E, Kiely, B, Marteau, P, Morelli, L, Ouwehand, A, Reniero, R, Saarela, M, Salminen, S, Saxelin, M, Schiffrin, E, Shanahan, F, Vaughan, E & von Wright, A 1999, 'Probiotics: Towards demonstrating efficacy', Trends in Food Science and Technology, vol. 10, no. 12, pp. 393-399. https://doi.org/10.1016/S0924-2244(00)00029-7

TY - JOUR

T1 - Probiotics

T2 - Towards demonstrating efficacy

AU - Mattila-Sandholm, Tiina

AU - Blum, S.

AU - Collins, J.K.

AU - Crittenden, Ross

AU - de Vos, Willem

AU - Dunne, C.

AU - Fondén, R.

AU - Grenov, G.

AU - Isolauri, Erika

AU - Kiely, B.

AU - Marteau, P.

AU - Morelli, L.

AU - Ouwehand, A.

AU - Reniero, R.

AU - Saarela, Maria

AU - Salminen, Seppo

AU - Saxelin, M.

AU - Schiffrin, E.

AU - Shanahan, F.

AU - Vaughan, E.

AU - von Wright, Atte

PY - 1999

Y1 - 1999

N2 - PROBDEMO, a multi-centre European research project, began in 1996 with the aim of demonstrating that probiotic micro-organisms can positively effect human health in rigorously conducted human clinical studies. These studies, now completed, have shown that some probiotics can influence the composition of the intestinal microbiota and modulate the host immune system with measurable benefits to health, including the control of atopic eczema in infants with food allergy. Considerable promise was also demonstrated for the use of selected probiotics in controlling inflammatory bowel disease, and infections in children and the elderly. The scientific approaches to selecting and evaluating probiotics that were demonstrated in the PROBDEMO project provide a model for food manufacturers to move further towards demonstrating efficacy for their probiotic products.

AB - PROBDEMO, a multi-centre European research project, began in 1996 with the aim of demonstrating that probiotic micro-organisms can positively effect human health in rigorously conducted human clinical studies. These studies, now completed, have shown that some probiotics can influence the composition of the intestinal microbiota and modulate the host immune system with measurable benefits to health, including the control of atopic eczema in infants with food allergy. Considerable promise was also demonstrated for the use of selected probiotics in controlling inflammatory bowel disease, and infections in children and the elderly. The scientific approaches to selecting and evaluating probiotics that were demonstrated in the PROBDEMO project provide a model for food manufacturers to move further towards demonstrating efficacy for their probiotic products.

U2 - 10.1016/S0924-2244(00)00029-7

DO - 10.1016/S0924-2244(00)00029-7

M3 - Review Article

SN - 0924-2244

VL - 10

SP - 393

EP - 399

JO - Trends in Food Science and Technology

JF - Trends in Food Science and Technology

IS - 12

ER -

Probiotics: Towards demonstrating efficacy

Abstract

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