Process control and drug analysis with an on-line capillary electrophoresis system

Heli Siren, Kaija Luomanperä, Teemu Työppönen, Stella Rovio, Pertti Vastamäki, Pekka Savolahti

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7 Citations (Scopus)


Inorganic and organic ions in pulp and paper process waters and drug mixtures were studied. Real-time measurements and on-line simulated analyses were made. A novel on-line capillary electrophoresis instrument equipped with a fixed wavelength UV detector having a 254-nm filter was used for the analysis. Three dynamic sample and electrolyte micromodules provided on-line sampling, sample introduction and solution feedings. The system was used to monitor process samples containing thiosulphate, chloride, sulphate, oxalate, acetate and carbonate. It approved good performance in separation of ethacrynic acid, furosemide, probenic, bumetanide and hydrochlorothiazide as well as that of normethanephrine, methanephrine and dopamine standard mixtures. The LOD and LOQ values of the ions and drugs ranged from 0.1 to 1 mg/l for LOD and from 1 to 10 mg/l for LOQ. Sensitivity of the drugs was higher due to the single wavelength available in the syste,. It required that the drugs were to be identified by indirect UV detection. Repeatibility of the analyses was good (RSD% below 5).
Original languageEnglish
Pages (from-to)295 - 307
JournalJournal of Biochemical and Biophysical Methods
Issue number3
Publication statusPublished - 2004
MoE publication typeA1 Journal article-refereed


  • on-line capillary electrophoresis
  • real-time monitoring
  • process
  • pulp and paper waters
  • drugs

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    Siren, H., Luomanperä, K., Työppönen, T., Rovio, S., Vastamäki, P., & Savolahti, P. (2004). Process control and drug analysis with an on-line capillary electrophoresis system. Journal of Biochemical and Biophysical Methods, 60(3), 295 - 307.