Production and applications of carbohydrate-derived sugar acids as generic biobased chemicals

Tuomas Mehtiö, Mervi Toivari, Marilyn G. Wiebe, Ali Harlin, Merja Penttilä (Corresponding Author), Anu Koivula

Research output: Contribution to journalArticleScientificpeer-review

14 Citations (Scopus)

Abstract

This review considers the chemical and biotechnological synthesis of acids that are obtained by direct oxidation of mono- or oligosaccharide, referred to as sugar acids. It focuses on sugar acids which can be readily derived from plant biomass sources and their current and future applications. The three main classes of sugar acids are aldonic, aldaric and uronic acids. Interest in organic acids derived from sugars has recently increased, as part of the interest to develop biorefineries which produce not only biofuels, but also chemicals to replace those currently derived from petroleum. More than half of the most desirable biologically produced platform chemicals are organic acids. Currently, the only sugar acid with high commercial production is d-gluconic acid. However, other sugar acids such as d-glucaric and meso-galactaric acids are being produced at a lower scale. The sugar acids have application as sequestering agents and binders, corrosion inhibitors, biodegradable chelators for pharmaceuticals and pH regulators. There is also considerable interest in the use of these molecules in the production of synthetic polymers, including polyamides, polyesters and hydrogels. Further development of these sugar acids will lead to higher volume production of the appropriate sugar acids and will help support the next generation of biorefineries.
Original languageEnglish
Pages (from-to)904-916
JournalCritical Reviews in Biotechnology
Volume36
Issue number5
DOIs
Publication statusPublished - 2016
MoE publication typeA1 Journal article-refereed

Fingerprint

Sugar Acids
Carbohydrates
Sequestering Agents
Uronic Acids
Hydrogels
Acids
Polyesters
Corrosion
Biofuels
Monosaccharides
Nylons
Petroleum
Chelating Agents
Oligosaccharides
Biomass
Polymers

Keywords

  • aldaric acid
  • aldonic acid
  • applications
  • biotechnology
  • enzyme
  • oxidation
  • sugar acid
  • uronic acid

Cite this

@article{65d16b85ab384633aa5c765bd11ee4d6,
title = "Production and applications of carbohydrate-derived sugar acids as generic biobased chemicals",
abstract = "This review considers the chemical and biotechnological synthesis of acids that are obtained by direct oxidation of mono- or oligosaccharide, referred to as sugar acids. It focuses on sugar acids which can be readily derived from plant biomass sources and their current and future applications. The three main classes of sugar acids are aldonic, aldaric and uronic acids. Interest in organic acids derived from sugars has recently increased, as part of the interest to develop biorefineries which produce not only biofuels, but also chemicals to replace those currently derived from petroleum. More than half of the most desirable biologically produced platform chemicals are organic acids. Currently, the only sugar acid with high commercial production is d-gluconic acid. However, other sugar acids such as d-glucaric and meso-galactaric acids are being produced at a lower scale. The sugar acids have application as sequestering agents and binders, corrosion inhibitors, biodegradable chelators for pharmaceuticals and pH regulators. There is also considerable interest in the use of these molecules in the production of synthetic polymers, including polyamides, polyesters and hydrogels. Further development of these sugar acids will lead to higher volume production of the appropriate sugar acids and will help support the next generation of biorefineries.",
keywords = "aldaric acid, aldonic acid, applications, biotechnology, enzyme, oxidation, sugar acid, uronic acid",
author = "Tuomas Mehti{\"o} and Mervi Toivari and Wiebe, {Marilyn G.} and Ali Harlin and Merja Penttil{\"a} and Anu Koivula",
year = "2016",
doi = "10.3109/07388551.2015.1060189",
language = "English",
volume = "36",
pages = "904--916",
journal = "Critical Reviews in Biotechnology",
issn = "0738-8551",
publisher = "Taylor & Francis",
number = "5",

}

TY - JOUR

T1 - Production and applications of carbohydrate-derived sugar acids as generic biobased chemicals

AU - Mehtiö, Tuomas

AU - Toivari, Mervi

AU - Wiebe, Marilyn G.

AU - Harlin, Ali

AU - Penttilä, Merja

AU - Koivula, Anu

PY - 2016

Y1 - 2016

N2 - This review considers the chemical and biotechnological synthesis of acids that are obtained by direct oxidation of mono- or oligosaccharide, referred to as sugar acids. It focuses on sugar acids which can be readily derived from plant biomass sources and their current and future applications. The three main classes of sugar acids are aldonic, aldaric and uronic acids. Interest in organic acids derived from sugars has recently increased, as part of the interest to develop biorefineries which produce not only biofuels, but also chemicals to replace those currently derived from petroleum. More than half of the most desirable biologically produced platform chemicals are organic acids. Currently, the only sugar acid with high commercial production is d-gluconic acid. However, other sugar acids such as d-glucaric and meso-galactaric acids are being produced at a lower scale. The sugar acids have application as sequestering agents and binders, corrosion inhibitors, biodegradable chelators for pharmaceuticals and pH regulators. There is also considerable interest in the use of these molecules in the production of synthetic polymers, including polyamides, polyesters and hydrogels. Further development of these sugar acids will lead to higher volume production of the appropriate sugar acids and will help support the next generation of biorefineries.

AB - This review considers the chemical and biotechnological synthesis of acids that are obtained by direct oxidation of mono- or oligosaccharide, referred to as sugar acids. It focuses on sugar acids which can be readily derived from plant biomass sources and their current and future applications. The three main classes of sugar acids are aldonic, aldaric and uronic acids. Interest in organic acids derived from sugars has recently increased, as part of the interest to develop biorefineries which produce not only biofuels, but also chemicals to replace those currently derived from petroleum. More than half of the most desirable biologically produced platform chemicals are organic acids. Currently, the only sugar acid with high commercial production is d-gluconic acid. However, other sugar acids such as d-glucaric and meso-galactaric acids are being produced at a lower scale. The sugar acids have application as sequestering agents and binders, corrosion inhibitors, biodegradable chelators for pharmaceuticals and pH regulators. There is also considerable interest in the use of these molecules in the production of synthetic polymers, including polyamides, polyesters and hydrogels. Further development of these sugar acids will lead to higher volume production of the appropriate sugar acids and will help support the next generation of biorefineries.

KW - aldaric acid

KW - aldonic acid

KW - applications

KW - biotechnology

KW - enzyme

KW - oxidation

KW - sugar acid

KW - uronic acid

U2 - 10.3109/07388551.2015.1060189

DO - 10.3109/07388551.2015.1060189

M3 - Article

VL - 36

SP - 904

EP - 916

JO - Critical Reviews in Biotechnology

JF - Critical Reviews in Biotechnology

SN - 0738-8551

IS - 5

ER -