Production of calcaride a by calcarisporium sp. in shaken flasks and stirred bioreactors

Anu Tamminen, Yanming Wang, Marilyn G. Wiebe (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

4 Citations (Scopus)


Increased interest in marine resources has led to increased screening of marine fungi for novel bioactive compounds and considerable effort is being invested in discovering these metabolites. For compound discovery, small-scale cultures are adequate, but agitated bioreactors are desirable for larger-scale production. Calcarisporium sp. KF525 has recently been described to produce calcaride A, a cyclic polyester with antibiotic activity, in agitated flasks. Here, we describe improvements in the production of calcaride A in both flasks (13-fold improvement) and stirred bioreactors (200-fold improvement). Production of calcaride A in bioreactors was initially substantially lower than in shaken flasks. The cultivation pH (reduced from 6.8 to
Original languageEnglish
Pages (from-to)3992-4005
JournalMarine Drugs
Issue number7
Publication statusPublished - 2015
MoE publication typeA1 Journal article-refereed


  • marine fungi
  • Calcarisporium
  • calcaride A
  • stirred tank bioreactor
  • pH
  • macrocylic polyester

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