Production of L-leucine nanoparticles under various conditions using an aerosol flow reactor method

Anna Lähde, Janne Raula, Esko I. Kauppinen (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

3 Citations (Scopus)

Abstract

We have studied the formation of L-leucine nanoparticles under various conditions using an aerosol flow reactor method. Temperatures and L-leucine concentrations for the experiments were selected to vary the saturation conditions for L-leucine in the reactor. In the two extreme cases, L-leucine is either in (i) the condensed phase (110 ºC) or completely in (ii) the vapour phase (200 ºC) for all concentrations; (iii) at the intermediate temperature (150 ºC), the extent of evaporation of L-leucine depends notably on the concentration, and thus partial evaporation and production of residual particles are expected. The size distribution of particles and the particle morphology varied according to formation mechanism with the geometric mean diameter of the particles between 30 nm and 210 nm. Hollow, spherical particles were obtained with the droplet-to-particle method without vaporisation of L-leucine; whereas leafy-looking particles were produced by homogeneous nucleation of supersaturated L-leucine vapour and subsequent growth by heterogeneous vapour deposition.
Original languageEnglish
Article number680897
Number of pages9
JournalJournal of Nanomaterials
Volume2008
DOIs
Publication statusPublished - 2008
MoE publication typeA1 Journal article-refereed

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Aerosols
Leucine
Evaporation
Vapors
Nanoparticles
Vapor deposition
Vaporization
Nucleation
Temperature
Experiments

Cite this

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title = "Production of L-leucine nanoparticles under various conditions using an aerosol flow reactor method",
abstract = "We have studied the formation of L-leucine nanoparticles under various conditions using an aerosol flow reactor method. Temperatures and L-leucine concentrations for the experiments were selected to vary the saturation conditions for L-leucine in the reactor. In the two extreme cases, L-leucine is either in (i) the condensed phase (110 ºC) or completely in (ii) the vapour phase (200 ºC) for all concentrations; (iii) at the intermediate temperature (150 ºC), the extent of evaporation of L-leucine depends notably on the concentration, and thus partial evaporation and production of residual particles are expected. The size distribution of particles and the particle morphology varied according to formation mechanism with the geometric mean diameter of the particles between 30 nm and 210 nm. Hollow, spherical particles were obtained with the droplet-to-particle method without vaporisation of L-leucine; whereas leafy-looking particles were produced by homogeneous nucleation of supersaturated L-leucine vapour and subsequent growth by heterogeneous vapour deposition.",
author = "Anna L{\"a}hde and Janne Raula and Kauppinen, {Esko I.}",
year = "2008",
doi = "10.1155/2008/680897",
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journal = "Journal of Nanomaterials",
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Production of L-leucine nanoparticles under various conditions using an aerosol flow reactor method. / Lähde, Anna; Raula, Janne; Kauppinen, Esko I. (Corresponding Author).

In: Journal of Nanomaterials, Vol. 2008, 680897, 2008.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Production of L-leucine nanoparticles under various conditions using an aerosol flow reactor method

AU - Lähde, Anna

AU - Raula, Janne

AU - Kauppinen, Esko I.

PY - 2008

Y1 - 2008

N2 - We have studied the formation of L-leucine nanoparticles under various conditions using an aerosol flow reactor method. Temperatures and L-leucine concentrations for the experiments were selected to vary the saturation conditions for L-leucine in the reactor. In the two extreme cases, L-leucine is either in (i) the condensed phase (110 ºC) or completely in (ii) the vapour phase (200 ºC) for all concentrations; (iii) at the intermediate temperature (150 ºC), the extent of evaporation of L-leucine depends notably on the concentration, and thus partial evaporation and production of residual particles are expected. The size distribution of particles and the particle morphology varied according to formation mechanism with the geometric mean diameter of the particles between 30 nm and 210 nm. Hollow, spherical particles were obtained with the droplet-to-particle method without vaporisation of L-leucine; whereas leafy-looking particles were produced by homogeneous nucleation of supersaturated L-leucine vapour and subsequent growth by heterogeneous vapour deposition.

AB - We have studied the formation of L-leucine nanoparticles under various conditions using an aerosol flow reactor method. Temperatures and L-leucine concentrations for the experiments were selected to vary the saturation conditions for L-leucine in the reactor. In the two extreme cases, L-leucine is either in (i) the condensed phase (110 ºC) or completely in (ii) the vapour phase (200 ºC) for all concentrations; (iii) at the intermediate temperature (150 ºC), the extent of evaporation of L-leucine depends notably on the concentration, and thus partial evaporation and production of residual particles are expected. The size distribution of particles and the particle morphology varied according to formation mechanism with the geometric mean diameter of the particles between 30 nm and 210 nm. Hollow, spherical particles were obtained with the droplet-to-particle method without vaporisation of L-leucine; whereas leafy-looking particles were produced by homogeneous nucleation of supersaturated L-leucine vapour and subsequent growth by heterogeneous vapour deposition.

U2 - 10.1155/2008/680897

DO - 10.1155/2008/680897

M3 - Article

VL - 2008

JO - Journal of Nanomaterials

JF - Journal of Nanomaterials

SN - 1687-4110

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ER -