Production of recombinant proteins in the filamentous fungus Trichoderma reesei

Sirkka Keränen, Merja Penttilä

    Research output: Contribution to journalArticleScientificpeer-review

    71 Citations (Scopus)

    Abstract

    The potential of the filamentous fungus Trichoderma reesei for producing heterologous proteins has recently been demonstrated with a number of secreted proteins. Rate-limiting steps and ways of improving the production have been studied, especially using antibody Fab fragments. Major improvements have been achieved by producing the foreign protein fused to the fungal cellulase cellobiohydrolase I. In addition the strong inducible cbh 1 promoter, other promoters, which are regulated in a different manner, have been developed.

    Original languageEnglish
    Pages (from-to)534-537
    Number of pages4
    JournalCurrent Opinion in Biotechnology
    Volume6
    Issue number5
    DOIs
    Publication statusPublished - 1 Jan 1995
    MoE publication typeA1 Journal article-refereed

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