Production of recombinant proteins in the filamentous fungus Trichoderma reesei

Sirkka Keränen, Merja Penttilä

Research output: Contribution to journalArticleScientificpeer-review

69 Citations (Scopus)

Abstract

The potential of the filamentous fungus Trichoderma reesei for producing heterologous proteins has recently been demonstrated with a number of secreted proteins. Rate-limiting steps and ways of improving the production have been studied, especially using antibody Fab fragments. Major improvements have been achieved by producing the foreign protein fused to the fungal cellulase cellobiohydrolase I. In addition the strong inducible cbh 1 promoter, other promoters, which are regulated in a different manner, have been developed.

Original languageEnglish
Pages (from-to)534-537
Number of pages4
JournalCurrent Opinion in Biotechnology
Volume6
Issue number5
DOIs
Publication statusPublished - 1 Jan 1995
MoE publication typeA1 Journal article-refereed

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