Abstract
| Original language | English |
|---|---|
| Title of host publication | 26th Fungal Genetics Conference |
| Subtitle of host publication | Programan and Abstracts |
| Publication status | Published - 2011 |
| MoE publication type | Not Eligible |
| Event | 26th Fungal Genetics Conference - Asilomar, United States Duration: 15 Mar 2011 → 20 Mar 2011 |
Publication series
| Series | Fungal Genetics Reports |
|---|---|
| Number | Supplement |
| Volume | 58 |
Conference
| Conference | 26th Fungal Genetics Conference |
|---|---|
| Country | United States |
| City | Asilomar |
| Period | 15/03/11 → 20/03/11 |
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Production of terpenes with Aspergillus nidulans. / Vuoristo, Kiira (Corresponding author); Bromann, Kirsi; Toivari, Mervi; Ruohonen, Laura; Nakari-Setälä, Tiina.
26th Fungal Genetics Conference: Programan and Abstracts. 2011. 349 (Fungal Genetics Reports; No. Supplement, Vol. 58).Research output: Chapter in Book/Report/Conference proceeding › Conference abstract in proceedings › Scientific
TY - CHAP
T1 - Production of terpenes with Aspergillus nidulans
AU - Vuoristo, Kiira
AU - Bromann, Kirsi
AU - Toivari, Mervi
AU - Ruohonen, Laura
AU - Nakari-Setälä, Tiina
PY - 2011
Y1 - 2011
N2 - Terpenes are a large and diverse group of hydrocarbons with many pharmaceutical and industrial applications including fragrances, preservatives, flavouring agents and drugs, e.g. anti-malarial artemisin, and the cancer drug Taxol. Terpenes with rearrangements in their carbon skeleton are referred to as terpenoids. The low water solubility, high volatility, cytotoxicity and complex structure of terpenoids make them difficult to produce in industrial scale. Modification of readily available precursors of terpenoids in filamentous fungi would present an alternative way to produce value-added compounds. There are not many reports on microbial transformation of terpenoids by fungi of the Aspergillus genus, although their ability to transform terpenes is recognised. The biotransformation of terpenes is of interest because it allows production of enantiomerically pure compounds under mild conditions. In nature, filamentous fungi produce terpenoids as secondary metabolites; i.e. they are not required for growth or development but instead function in communication or defence. The fungal terpenoids are involved in pathogenesis, production of toxins (e.g. alfatoxin), and utilization of specific carbon sources. Filamentous fungi have been widely used in industrial scale production of various compounds and especially Aspergillus niger and Aspergillus nidulans represent potential host organisms for the production and modification of various terpenoid products. This work describes genetic engineering of A. nidulans for terpenoid production. The aim is to study the potential of this organism for terpenoid production and isolate interesting terpenoid products or their precursors.
AB - Terpenes are a large and diverse group of hydrocarbons with many pharmaceutical and industrial applications including fragrances, preservatives, flavouring agents and drugs, e.g. anti-malarial artemisin, and the cancer drug Taxol. Terpenes with rearrangements in their carbon skeleton are referred to as terpenoids. The low water solubility, high volatility, cytotoxicity and complex structure of terpenoids make them difficult to produce in industrial scale. Modification of readily available precursors of terpenoids in filamentous fungi would present an alternative way to produce value-added compounds. There are not many reports on microbial transformation of terpenoids by fungi of the Aspergillus genus, although their ability to transform terpenes is recognised. The biotransformation of terpenes is of interest because it allows production of enantiomerically pure compounds under mild conditions. In nature, filamentous fungi produce terpenoids as secondary metabolites; i.e. they are not required for growth or development but instead function in communication or defence. The fungal terpenoids are involved in pathogenesis, production of toxins (e.g. alfatoxin), and utilization of specific carbon sources. Filamentous fungi have been widely used in industrial scale production of various compounds and especially Aspergillus niger and Aspergillus nidulans represent potential host organisms for the production and modification of various terpenoid products. This work describes genetic engineering of A. nidulans for terpenoid production. The aim is to study the potential of this organism for terpenoid production and isolate interesting terpenoid products or their precursors.
M3 - Conference abstract in proceedings
T3 - Fungal Genetics Reports
BT - 26th Fungal Genetics Conference
ER -