Production of terpenes with Aspergillus nidulans

Kiira Vuoristo (Corresponding author), Kirsi Bromann, Mervi Toivari, Laura Ruohonen, Tiina Nakari-Setälä

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Abstract

Terpenes are a large and diverse group of hydrocarbons with many pharmaceutical and industrial applications including fragrances, preservatives, flavouring agents and drugs, e.g. anti-malarial artemisin, and the cancer drug Taxol. Terpenes with rearrangements in their carbon skeleton are referred to as terpenoids. The low water solubility, high volatility, cytotoxicity and complex structure of terpenoids make them difficult to produce in industrial scale. Modification of readily available precursors of terpenoids in filamentous fungi would present an alternative way to produce value-added compounds. There are not many reports on microbial transformation of terpenoids by fungi of the Aspergillus genus, although their ability to transform terpenes is recognised. The biotransformation of terpenes is of interest because it allows production of enantiomerically pure compounds under mild conditions. In nature, filamentous fungi produce terpenoids as secondary metabolites; i.e. they are not required for growth or development but instead function in communication or defence. The fungal terpenoids are involved in pathogenesis, production of toxins (e.g. alfatoxin), and utilization of specific carbon sources. Filamentous fungi have been widely used in industrial scale production of various compounds and especially Aspergillus niger and Aspergillus nidulans represent potential host organisms for the production and modification of various terpenoid products. This work describes genetic engineering of A. nidulans for terpenoid production. The aim is to study the potential of this organism for terpenoid production and isolate interesting terpenoid products or their precursors.
Original languageEnglish
Title of host publication26th Fungal Genetics Conference
Subtitle of host publicationPrograman and Abstracts
Publication statusPublished - 2011
MoE publication typeNot Eligible
Event26th Fungal Genetics Conference - Asilomar, United States
Duration: 15 Mar 201120 Mar 2011

Publication series

NameFungal Genetics Reports
NumberSupplement
Volume58

Conference

Conference26th Fungal Genetics Conference
CountryUnited States
CityAsilomar
Period15/03/1120/03/11

Fingerprint

Aspergillus nidulans
terpenoids
fungi
drugs
antimalarials
paclitaxel
carbon
water solubility
organisms
industrial applications
flavorings
value added
preservatives
biotransformation
Aspergillus niger
genetic engineering
Aspergillus
animal communication
secondary metabolites
skeleton

Cite this

Vuoristo, K., Bromann, K., Toivari, M., Ruohonen, L., & Nakari-Setälä, T. (2011). Production of terpenes with Aspergillus nidulans. In 26th Fungal Genetics Conference: Programan and Abstracts [349] Fungal Genetics Reports, No. Supplement, Vol.. 58
Vuoristo, Kiira ; Bromann, Kirsi ; Toivari, Mervi ; Ruohonen, Laura ; Nakari-Setälä, Tiina. / Production of terpenes with Aspergillus nidulans. 26th Fungal Genetics Conference: Programan and Abstracts. 2011. (Fungal Genetics Reports; No. Supplement, Vol. 58).
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Vuoristo, K, Bromann, K, Toivari, M, Ruohonen, L & Nakari-Setälä, T 2011, Production of terpenes with Aspergillus nidulans. in 26th Fungal Genetics Conference: Programan and Abstracts., 349, Fungal Genetics Reports, no. Supplement, vol. 58, 26th Fungal Genetics Conference, Asilomar, United States, 15/03/11.

Production of terpenes with Aspergillus nidulans. / Vuoristo, Kiira (Corresponding author); Bromann, Kirsi; Toivari, Mervi; Ruohonen, Laura; Nakari-Setälä, Tiina.

26th Fungal Genetics Conference: Programan and Abstracts. 2011. 349 (Fungal Genetics Reports; No. Supplement, Vol. 58).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

TY - CHAP

T1 - Production of terpenes with Aspergillus nidulans

AU - Vuoristo, Kiira

AU - Bromann, Kirsi

AU - Toivari, Mervi

AU - Ruohonen, Laura

AU - Nakari-Setälä, Tiina

PY - 2011

Y1 - 2011

N2 - Terpenes are a large and diverse group of hydrocarbons with many pharmaceutical and industrial applications including fragrances, preservatives, flavouring agents and drugs, e.g. anti-malarial artemisin, and the cancer drug Taxol. Terpenes with rearrangements in their carbon skeleton are referred to as terpenoids. The low water solubility, high volatility, cytotoxicity and complex structure of terpenoids make them difficult to produce in industrial scale. Modification of readily available precursors of terpenoids in filamentous fungi would present an alternative way to produce value-added compounds. There are not many reports on microbial transformation of terpenoids by fungi of the Aspergillus genus, although their ability to transform terpenes is recognised. The biotransformation of terpenes is of interest because it allows production of enantiomerically pure compounds under mild conditions. In nature, filamentous fungi produce terpenoids as secondary metabolites; i.e. they are not required for growth or development but instead function in communication or defence. The fungal terpenoids are involved in pathogenesis, production of toxins (e.g. alfatoxin), and utilization of specific carbon sources. Filamentous fungi have been widely used in industrial scale production of various compounds and especially Aspergillus niger and Aspergillus nidulans represent potential host organisms for the production and modification of various terpenoid products. This work describes genetic engineering of A. nidulans for terpenoid production. The aim is to study the potential of this organism for terpenoid production and isolate interesting terpenoid products or their precursors.

AB - Terpenes are a large and diverse group of hydrocarbons with many pharmaceutical and industrial applications including fragrances, preservatives, flavouring agents and drugs, e.g. anti-malarial artemisin, and the cancer drug Taxol. Terpenes with rearrangements in their carbon skeleton are referred to as terpenoids. The low water solubility, high volatility, cytotoxicity and complex structure of terpenoids make them difficult to produce in industrial scale. Modification of readily available precursors of terpenoids in filamentous fungi would present an alternative way to produce value-added compounds. There are not many reports on microbial transformation of terpenoids by fungi of the Aspergillus genus, although their ability to transform terpenes is recognised. The biotransformation of terpenes is of interest because it allows production of enantiomerically pure compounds under mild conditions. In nature, filamentous fungi produce terpenoids as secondary metabolites; i.e. they are not required for growth or development but instead function in communication or defence. The fungal terpenoids are involved in pathogenesis, production of toxins (e.g. alfatoxin), and utilization of specific carbon sources. Filamentous fungi have been widely used in industrial scale production of various compounds and especially Aspergillus niger and Aspergillus nidulans represent potential host organisms for the production and modification of various terpenoid products. This work describes genetic engineering of A. nidulans for terpenoid production. The aim is to study the potential of this organism for terpenoid production and isolate interesting terpenoid products or their precursors.

M3 - Conference abstract in proceedings

T3 - Fungal Genetics Reports

BT - 26th Fungal Genetics Conference

ER -

Vuoristo K, Bromann K, Toivari M, Ruohonen L, Nakari-Setälä T. Production of terpenes with Aspergillus nidulans. In 26th Fungal Genetics Conference: Programan and Abstracts. 2011. 349. (Fungal Genetics Reports; No. Supplement, Vol. 58).