Abstract
Sleep loss and insufficient sleep are risk factors for
cardiometabolic diseases, but data on how insufficient
sleep contributes to these diseases are scarce. These
questions were addressed using two approaches: an
experimental, partial sleep restriction study (14 cases
and 7 control subjects) with objective verification of
sleep amount, and two independent epidemiological cohorts
(altogether 2739 individuals) with questions of sleep
insufficiency. In both approaches, blood transcriptome
and serum metabolome were analysed. Sleep loss decreased
the expression of genes encoding cholesterol transporters
and increased expression in pathways involved in
inflammatory responses in both paradigms. Metabolomic
analyses revealed lower circulating large HDL in the
population cohorts among subjects reporting insufficient
sleep, while circulating LDL decreased in the
experimental sleep restriction study. These findings
suggest that prolonged sleep deprivation modifies
inflammatory and cholesterol pathways at the level of
gene expression and serum lipoproteins, inducing changes
toward potentially higher risk for cardiometabolic
diseases.
Original language | English |
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Article number | 24828 |
Journal | Scientific Reports |
Volume | 6 |
DOIs | |
Publication status | Published - 2016 |
MoE publication type | A1 Journal article-refereed |
Keywords
- Chronic inflammation
- Dyslipidaemias
- Epidemiology
- Gene expression
- Sleep deprivation