Prolyl oligopeptidase inhibition reduces PolyQ aggregation and improves cell viability in cellular model of Huntington’s disease

Susanna Norrbacka; Dan Lindholm; Timo T. Myöhänen

doi:10.1111/jcmm.14675

Prolyl oligopeptidase inhibition reduces PolyQ aggregation and improves cell viability in cellular model of Huntington’s disease

Susanna Norrbacka
, Dan Lindholm
, Timo T. Myöhänen^*

^*Corresponding author for this work

Not published at VTT

University of Helsinki

Research output: Contribution to journal › Article › Scientific › peer-review

6 Citations (Scopus)

Original language	English
Pages (from-to)	8511-8515
Number of pages	5
Journal	Journal of Cellular and Molecular Medicine
Volume	23
Issue number	12
DOIs	https://doi.org/10.1111/jcmm.14675
Publication status	Published - 1 Dec 2019
MoE publication type	A1 Journal article-refereed

Funding

This study was supported by Academy of Finland (grants 303833, 267788, and 273799), University of Helsinki 3-year grant, Jane and Aatos Erkko Foundation and Sigrid Juselius Foundation grants for TTM. This study was supported by Academy of Finland (grants 303833, 267788, and 273799), University of Helsinki 3‐year grant, Jane and Aatos Erkko Foundation and Sigrid Juselius Foundation grants for TTM.

Keywords

autophagy
huntingtin
neurodegeneration
protein aggregation
protein processing

Access to Document

10.1111/jcmm.14675

Cite this

@article{1daefcbca2264116adc41047e45ed64b,

title = "Prolyl oligopeptidase inhibition reduces PolyQ aggregation and improves cell viability in cellular model of Huntington{\textquoteright}s disease",

keywords = "autophagy, huntingtin, neurodegeneration, protein aggregation, protein processing",

author = "Susanna Norrbacka and Dan Lindholm and My{\"o}h{\"a}nen, \{Timo T.\}",

note = "Funding Information: This study was supported by Academy of Finland (grants 303833, 267788, and 273799), University of Helsinki 3-year grant, Jane and Aatos Erkko Foundation and Sigrid Juselius Foundation grants for TTM. Funding Information: This study was supported by Academy of Finland (grants 303833, 267788, and 273799), University of Helsinki 3‐year grant, Jane and Aatos Erkko Foundation and Sigrid Juselius Foundation grants for TTM. ",

year = "2019",

month = dec,

day = "1",

doi = "10.1111/jcmm.14675",

language = "English",

volume = "23",

pages = "8511--8515",

journal = "Journal of Cellular and Molecular Medicine",

issn = "1582-1838",

publisher = "Wiley",

number = "12",

}

TY - JOUR

T1 - Prolyl oligopeptidase inhibition reduces PolyQ aggregation and improves cell viability in cellular model of Huntington’s disease

AU - Norrbacka, Susanna

AU - Lindholm, Dan

AU - Myöhänen, Timo T.

N1 - Funding Information: This study was supported by Academy of Finland (grants 303833, 267788, and 273799), University of Helsinki 3-year grant, Jane and Aatos Erkko Foundation and Sigrid Juselius Foundation grants for TTM. Funding Information: This study was supported by Academy of Finland (grants 303833, 267788, and 273799), University of Helsinki 3‐year grant, Jane and Aatos Erkko Foundation and Sigrid Juselius Foundation grants for TTM.

PY - 2019/12/1

Y1 - 2019/12/1

KW - autophagy

KW - huntingtin

KW - neurodegeneration

KW - protein aggregation

KW - protein processing

UR - https://www.scopus.com/pages/publications/85073969416

U2 - 10.1111/jcmm.14675

DO - 10.1111/jcmm.14675

M3 - Article

C2 - 31565846

AN - SCOPUS:85073969416

SN - 1582-1838

VL - 23

SP - 8511

EP - 8515

JO - Journal of Cellular and Molecular Medicine

JF - Journal of Cellular and Molecular Medicine

IS - 12

ER -

Prolyl oligopeptidase inhibition reduces PolyQ aggregation and improves cell viability in cellular model of Huntington’s disease

Funding

Keywords

Access to Document

Other files and links

Cite this