Protein production in filamentous fungal cells in the absence of inducing substrates

Michael Ward (Inventor), Yun Luo (Inventor), Felipe Oseas Bendezu (Inventor), Mari Valkonen (Inventor), Markku Saloheimo (Inventor), Nina Aro (Inventor), Tiina Pakula (Inventor)

    Research output: PatentPatent


    Certain embodiments of the disclosure are directed to variant filamentous fungal cells, compositions thereof and methods thereof for increased production of one or more proteins of interest. More particularly, in certain embodiments, the disclosure is directed to variant filamentous fungal (host) cells derived from parental filamentous fungal cells, wherein the variant host cells comprise a genetic modification which enables the expression/production of a protein of interest (POI) in the absence of inducing substrate. In certain embodiments, a variant fungal host cell of the disclosure comprises a genetic modification which increases the expression of a variant activator of cellulase expression 3 (ace3) gene encoding an Ace3 protein referred to herein as Ace3-L.

    Patent family as of 26.8.2021
    CN109790510 A 20190521 CN201780059992 20171003      
    EP3523415 A1 20190814 EP20170794124 20171003      
    JP2019528797 T2 20191017 JP20190539732T 20171003     
    KR20190057088 A 20190527 KR20197010929 20171003      
    US10876103 BB 20201229 US20170336500 20171003      
    US2019309276 AA 20191010 US20170336500 20171003      
    WO18067599 A1 20180412 WO2017US54983 20171003

    Link to current patent family on right

    Original languageEnglish
    Patent numberUS2019309276
    IPCC12N 15/ 80 A I
    Priority date3/10/17
    Publication statusPublished - 10 Oct 2019
    MoE publication typeH1 Granted patent


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