PYTHIA Project Realizes First All-Si Truly Integrated Mach-Zehnder Biosensor Arrays for Label-free Detection Schemes

G. Jobst, I. Moser, R. Stoffer, M. Hoekman, R. Heideman, H. Leeuwis, Kari Tukkiniemi, Kirsi Tappura, S. Kamakari, G. Nounessis, S. Bhattacharya, J. Rysz, A. Budkowski, M. Kitsara, E. Makarona, P. Petrou, S. Kakabakos, K. Misiakos, I. Raptis

Research output: Contribution to journalArticleProfessional

Abstract

PYTHIA project aims at the development of an innovative optoelectronic biochip for the early diagnosis of human diseases through label-free multi-analyte detection. The basic optoelectronic transducer consists of a VIS-NIR light source and an interferometric waveguide all monolithically integrated on a single Si chip. The transducer's ultimate integration level allows for the development of arrays consisting of individually functionalized interferometers coupled to their excitation source, and converging to a common detector for multiplexed operation. Encapsulation with a microfluidic system allows for the easy delivery of samples, while boarding on a disposable cartridge ensures the facile contact with the measuring apparatus. Preliminary, not-fully optimized biochips tested with model assays easily detected the binding ofstreptavidin in the pM-range, competing with the state-of-the-art label-free biosensors. The final system will be capable of simultaneous multi-analyte detection, real-time reaction monitoring and data processing, requiring minimal sample volumes and a few minutes of operation. (0 refs.)
Original languageEnglish
Pages (from-to)10-12
JournalMST News
Issue number1
Publication statusPublished - 2010
MoE publication typeD1 Article in a trade journal

Fingerprint

bioinstrumentation
transducers
cartridges
reaction time
delivery
light sources
interferometers
chips
waveguides
detectors
excitation

Cite this

Jobst, G., Moser, I., Stoffer, R., Hoekman, M., Heideman, R., Leeuwis, H., ... Raptis, I. (2010). PYTHIA Project Realizes First All-Si Truly Integrated Mach-Zehnder Biosensor Arrays for Label-free Detection Schemes. MST News, (1), 10-12.
Jobst, G. ; Moser, I. ; Stoffer, R. ; Hoekman, M. ; Heideman, R. ; Leeuwis, H. ; Tukkiniemi, Kari ; Tappura, Kirsi ; Kamakari, S. ; Nounessis, G. ; Bhattacharya, S. ; Rysz, J. ; Budkowski, A. ; Kitsara, M. ; Makarona, E. ; Petrou, P. ; Kakabakos, S. ; Misiakos, K. ; Raptis, I. / PYTHIA Project Realizes First All-Si Truly Integrated Mach-Zehnder Biosensor Arrays for Label-free Detection Schemes. In: MST News. 2010 ; No. 1. pp. 10-12.
@article{1251543358dc49abbda2b81fcdbb2b6c,
title = "PYTHIA Project Realizes First All-Si Truly Integrated Mach-Zehnder Biosensor Arrays for Label-free Detection Schemes",
abstract = "PYTHIA project aims at the development of an innovative optoelectronic biochip for the early diagnosis of human diseases through label-free multi-analyte detection. The basic optoelectronic transducer consists of a VIS-NIR light source and an interferometric waveguide all monolithically integrated on a single Si chip. The transducer's ultimate integration level allows for the development of arrays consisting of individually functionalized interferometers coupled to their excitation source, and converging to a common detector for multiplexed operation. Encapsulation with a microfluidic system allows for the easy delivery of samples, while boarding on a disposable cartridge ensures the facile contact with the measuring apparatus. Preliminary, not-fully optimized biochips tested with model assays easily detected the binding ofstreptavidin in the pM-range, competing with the state-of-the-art label-free biosensors. The final system will be capable of simultaneous multi-analyte detection, real-time reaction monitoring and data processing, requiring minimal sample volumes and a few minutes of operation. (0 refs.)",
author = "G. Jobst and I. Moser and R. Stoffer and M. Hoekman and R. Heideman and H. Leeuwis and Kari Tukkiniemi and Kirsi Tappura and S. Kamakari and G. Nounessis and S. Bhattacharya and J. Rysz and A. Budkowski and M. Kitsara and E. Makarona and P. Petrou and S. Kakabakos and K. Misiakos and I. Raptis",
year = "2010",
language = "English",
pages = "10--12",
journal = "MST News",
issn = "0948-3128",
number = "1",

}

Jobst, G, Moser, I, Stoffer, R, Hoekman, M, Heideman, R, Leeuwis, H, Tukkiniemi, K, Tappura, K, Kamakari, S, Nounessis, G, Bhattacharya, S, Rysz, J, Budkowski, A, Kitsara, M, Makarona, E, Petrou, P, Kakabakos, S, Misiakos, K & Raptis, I 2010, 'PYTHIA Project Realizes First All-Si Truly Integrated Mach-Zehnder Biosensor Arrays for Label-free Detection Schemes', MST News, no. 1, pp. 10-12.

PYTHIA Project Realizes First All-Si Truly Integrated Mach-Zehnder Biosensor Arrays for Label-free Detection Schemes. / Jobst, G.; Moser, I.; Stoffer, R.; Hoekman, M.; Heideman, R.; Leeuwis, H.; Tukkiniemi, Kari; Tappura, Kirsi; Kamakari, S.; Nounessis, G.; Bhattacharya, S.; Rysz, J.; Budkowski, A.; Kitsara, M.; Makarona, E.; Petrou, P.; Kakabakos, S.; Misiakos, K.; Raptis, I.

In: MST News, No. 1, 2010, p. 10-12.

Research output: Contribution to journalArticleProfessional

TY - JOUR

T1 - PYTHIA Project Realizes First All-Si Truly Integrated Mach-Zehnder Biosensor Arrays for Label-free Detection Schemes

AU - Jobst, G.

AU - Moser, I.

AU - Stoffer, R.

AU - Hoekman, M.

AU - Heideman, R.

AU - Leeuwis, H.

AU - Tukkiniemi, Kari

AU - Tappura, Kirsi

AU - Kamakari, S.

AU - Nounessis, G.

AU - Bhattacharya, S.

AU - Rysz, J.

AU - Budkowski, A.

AU - Kitsara, M.

AU - Makarona, E.

AU - Petrou, P.

AU - Kakabakos, S.

AU - Misiakos, K.

AU - Raptis, I.

PY - 2010

Y1 - 2010

N2 - PYTHIA project aims at the development of an innovative optoelectronic biochip for the early diagnosis of human diseases through label-free multi-analyte detection. The basic optoelectronic transducer consists of a VIS-NIR light source and an interferometric waveguide all monolithically integrated on a single Si chip. The transducer's ultimate integration level allows for the development of arrays consisting of individually functionalized interferometers coupled to their excitation source, and converging to a common detector for multiplexed operation. Encapsulation with a microfluidic system allows for the easy delivery of samples, while boarding on a disposable cartridge ensures the facile contact with the measuring apparatus. Preliminary, not-fully optimized biochips tested with model assays easily detected the binding ofstreptavidin in the pM-range, competing with the state-of-the-art label-free biosensors. The final system will be capable of simultaneous multi-analyte detection, real-time reaction monitoring and data processing, requiring minimal sample volumes and a few minutes of operation. (0 refs.)

AB - PYTHIA project aims at the development of an innovative optoelectronic biochip for the early diagnosis of human diseases through label-free multi-analyte detection. The basic optoelectronic transducer consists of a VIS-NIR light source and an interferometric waveguide all monolithically integrated on a single Si chip. The transducer's ultimate integration level allows for the development of arrays consisting of individually functionalized interferometers coupled to their excitation source, and converging to a common detector for multiplexed operation. Encapsulation with a microfluidic system allows for the easy delivery of samples, while boarding on a disposable cartridge ensures the facile contact with the measuring apparatus. Preliminary, not-fully optimized biochips tested with model assays easily detected the binding ofstreptavidin in the pM-range, competing with the state-of-the-art label-free biosensors. The final system will be capable of simultaneous multi-analyte detection, real-time reaction monitoring and data processing, requiring minimal sample volumes and a few minutes of operation. (0 refs.)

M3 - Article

SP - 10

EP - 12

JO - MST News

JF - MST News

SN - 0948-3128

IS - 1

ER -

Jobst G, Moser I, Stoffer R, Hoekman M, Heideman R, Leeuwis H et al. PYTHIA Project Realizes First All-Si Truly Integrated Mach-Zehnder Biosensor Arrays for Label-free Detection Schemes. MST News. 2010;(1):10-12.