PYTHIA Project Realizes First All-Si Truly Integrated Mach-Zehnder Biosensor Arrays for Label-free Detection Schemes

G. Jobst, I. Moser, R. Stoffer, M. Hoekman, R. Heideman, H. Leeuwis, Kari Tukkiniemi, Kirsi Tappura, S. Kamakari, G. Nounessis, S. Bhattacharya, J. Rysz, A. Budkowski, M. Kitsara, E. Makarona, P. Petrou, S. Kakabakos, K. Misiakos, I. Raptis

    Research output: Contribution to journalArticleProfessional

    Abstract

    PYTHIA project aims at the development of an innovative optoelectronic biochip for the early diagnosis of human diseases through label-free multi-analyte detection. The basic optoelectronic transducer consists of a VIS-NIR light source and an interferometric waveguide all monolithically integrated on a single Si chip. The transducer's ultimate integration level allows for the development of arrays consisting of individually functionalized interferometers coupled to their excitation source, and converging to a common detector for multiplexed operation. Encapsulation with a microfluidic system allows for the easy delivery of samples, while boarding on a disposable cartridge ensures the facile contact with the measuring apparatus. Preliminary, not-fully optimized biochips tested with model assays easily detected the binding ofstreptavidin in the pM-range, competing with the state-of-the-art label-free biosensors. The final system will be capable of simultaneous multi-analyte detection, real-time reaction monitoring and data processing, requiring minimal sample volumes and a few minutes of operation. (0 refs.)
    Original languageEnglish
    Pages (from-to)10-12
    JournalMST News
    Issue number1
    Publication statusPublished - 2010
    MoE publication typeD1 Article in a trade journal

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  • Cite this

    Jobst, G., Moser, I., Stoffer, R., Hoekman, M., Heideman, R., Leeuwis, H., Tukkiniemi, K., Tappura, K., Kamakari, S., Nounessis, G., Bhattacharya, S., Rysz, J., Budkowski, A., Kitsara, M., Makarona, E., Petrou, P., Kakabakos, S., Misiakos, K., & Raptis, I. (2010). PYTHIA Project Realizes First All-Si Truly Integrated Mach-Zehnder Biosensor Arrays for Label-free Detection Schemes. MST News, (1), 10-12.