Quality assurance of BNCT dosimetry

Johanna Karila, Hanna Bjugg, Iiro Auterinen, Petri Kotiluoto, Mika Kortesniemi, Tom Seren, Tiina Seppälä, Jussi Perkiö, Päivi Ryynänen, Sauli Savolainen

    Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

    Abstract

    The Phase I clinical trials for boron neutron capture therapy (BNCT) started in May 1999 in Otaniemi, Espoo. For BNCT no uniform international guidance for the quality assurance of dosimetry exists, so far. Because of the complex dose distribution with several different dose components, the international recommendations on conventional radiotherapy dosimetry are not applicable in every part. Therefore, special guidance specifically for BNCT is needed. To obtain such guidelines (Code of Practice) a European collaboration project has been defined. The quality assurance of the dosimetry in BNCT in Finland covers each step of the BNCT treatment, which include dose planning imaging, dose planning, boron infusion, boron kinetics, patient positioning, monitoring of the treatment beam, characterising the radiation spectrum, calibration of the beam model and the dosimetric measurements both in patients (in vivo measurements) and in various phantoms. The dose planning images are obtained using a MR scanner with MRI sensitive markers and the dose distribution is computed with a dose planning software BNCT_Rtpe. The program and the treatment beam (DORT) model used have been verified with measurements and validated with MCNP calculations in phantom. Dosimetric intercomparison has been done with the Brookhaven BNCT beam (BMRR). Before every patient irradiation the relationship between the beam monitor pulse rate and neutron fluence rate in the beam is checked by activation measurements. Kinetic models used to estimate the time-behavior of the blood boron concentration have been verified using independent patient sample data. For the measurement of the absorbed doses in patients and phantoms, TL dosimeters and activation foils are used. At the moment the quality assurance of dosimetry in BNCT in Finland is according to the EU rules and planned recommendations and thus sufficient. Nevertheless microdosimetric measurement methods and Fricke gels are planned to bring to use in addition to the dosimetric methods already utilised in order to intensify the quality assurance.
    Original languageEnglish
    Title of host publicationProceedings of the XXXV Annual Conference of the Finnish Physical Society
    Place of PublicationJyväskylä
    PublisherUniversity of Jyväskylä
    ISBN (Print)951-39-0942-5
    Publication statusPublished - 2001
    MoE publication typeNot Eligible
    EventPhysics Days - Fysiikan Päivät 2001: 35th Annual Conference of the Finnish Physical Society - Jyväskylä, Finland
    Duration: 22 Mar 200124 Mar 2001
    Conference number: 35

    Publication series

    SeriesUniversity of Jyväskylä: Department of Physics. Research Report
    Number5-2001
    ISSN0075-465X

    Conference

    ConferencePhysics Days - Fysiikan Päivät 2001
    CountryFinland
    CityJyväskylä
    Period22/03/0124/03/01

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  • Cite this

    Karila, J., Bjugg, H., Auterinen, I., Kotiluoto, P., Kortesniemi, M., Seren, T., Seppälä, T., Perkiö, J., Ryynänen, P., & Savolainen, S. (2001). Quality assurance of BNCT dosimetry. In Proceedings of the XXXV Annual Conference of the Finnish Physical Society [145] University of Jyväskylä. University of Jyväskylä: Department of Physics. Research Report, No. 5-2001