Quantification of haemodynamic response to auditory stimulus in intensive care

Ilkka Korhonen (Corresponding Author), Jari Karhu, Luca Mainardi, Jakob Stephan

Research output: Contribution to journalArticleScientificpeer-review

3 Citations (Scopus)


Measuring effects of sensory stimuli on haemodynamics could provide information about the interplay between central and autonomous nervous system (ANS). However, ANS response to sensory stimulus has received little attention. In this paper we present a signal processing scheme to extract the responses of heart rate and systemic arterial pressure on auditory stimulus in intensive care patients (N=5). In short, the effect of mechanical ventilation is rejected by optimal linear modelling. Other disturbances are attenuated by filtering and efficient rejection of outlying sweeps of data. The results show identifiable responses on three out of five cases. The response characteristics may be explained by synchronisation of spontaneous variability in systemic arterial pressure to auditory stimulus.

Original languageEnglish
Pages (from-to)211-218
JournalComputer Methods and Programs in Biomedicine
Issue number3
Publication statusPublished - 2000
MoE publication typeA1 Journal article-refereed


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