Abstract
In spite of radical advances in nanobiotechnology, the clinical translation of nanoparticle (NP)-based agents is still a major challenge due to various physiological factors that influence their interactions with biological systems. Recent decade witnessed meticulous investigation on protein corona (PC) that is the first surrounds NPs once administered into the body. Formation of PC around NP surface exhibits resilient effects on their circulation, distribution, therapeutic activity, toxicity and other factors. Although enormous literature is available on the role of PC in altering pharmacokinetics and pharmacodynamics of NPs, understanding on its analytical characterization methods still remains shallow. Therefore, the current review summarizes the impact of PC on biological fate of NPs and stressing on analytical methods employed for studying the NP-PC.
| Original language | English |
|---|---|
| Pages (from-to) | 1037-1061 |
| Number of pages | 25 |
| Journal | Nanomedicine |
| Volume | 15 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Apr 2020 |
| MoE publication type | A2 Review article in a scientific journal |
Keywords
- analytical techniques
- clinical translation
- hard corona
- nanomedicines
- protein corona
- soft corona