Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat

Hnin Yin Yin Nyein, Mallika Bariya, Liisa Kivimäki, Sanna Uusitalo, Tiffany Sun Liaw, Elina Jansson, Christine Heera Ahn, John A. Hangasky, Jiangqi Zhao, Yuanjing Lin, Tuomas Happonen, Minghan Chao, Christina Liedert, Yingbo Zhao, Li Chia Tai, Jussi Hiltunen, Ali Javey (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Recent technological advancements in wearable sensors have made it easier to detect sweat components, but our limited understanding of sweat restricts its application. A critical bottleneck for temporal and regional sweat analysis is achieving uniform, high-throughput fabrication of sweat sensor components, including microfluidic chip and sensing electrodes. To overcome this challenge, we introduce microfluidic sensing patches mass fabricated via roll-to-roll (R2R) processes. The patch allows sweat capture within a spiral microfluidic for real-time measurement of sweat parameters including [Na+], [K+], [glucose], and sweat rate in exercise and chemically induced sweat. The patch is demonstrated for investigating regional sweat composition, predicting whole-body fluid/electrolyte loss during exercise, uncovering relationships between sweat metrics, and tracking glucose dynamics to explore sweat-to-blood correlations in healthy and diabetic individuals. By enabling a comprehensive sweat analysis, the presented device is a crucial tool for advancing sweat testing beyond the research stage for point-of-care medical and athletic applications.
Original languageEnglish
Article numbereaaw9906
Number of pages13
JournalScience advances
Volume5
Issue number8
DOIs
Publication statusPublished - 16 Aug 2019
MoE publication typeA1 Journal article-refereed

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sweat
decoding
physical exercise
glucose
body fluids
sensors

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Nyein, Hnin Yin Yin ; Bariya, Mallika ; Kivimäki, Liisa ; Uusitalo, Sanna ; Liaw, Tiffany Sun ; Jansson, Elina ; Ahn, Christine Heera ; Hangasky, John A. ; Zhao, Jiangqi ; Lin, Yuanjing ; Happonen, Tuomas ; Chao, Minghan ; Liedert, Christina ; Zhao, Yingbo ; Tai, Li Chia ; Hiltunen, Jussi ; Javey, Ali. / Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat. In: Science advances. 2019 ; Vol. 5, No. 8.
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title = "Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat",
abstract = "Recent technological advancements in wearable sensors have made it easier to detect sweat components, but our limited understanding of sweat restricts its application. A critical bottleneck for temporal and regional sweat analysis is achieving uniform, high-throughput fabrication of sweat sensor components, including microfluidic chip and sensing electrodes. To overcome this challenge, we introduce microfluidic sensing patches mass fabricated via roll-to-roll (R2R) processes. The patch allows sweat capture within a spiral microfluidic for real-time measurement of sweat parameters including [Na+], [K+], [glucose], and sweat rate in exercise and chemically induced sweat. The patch is demonstrated for investigating regional sweat composition, predicting whole-body fluid/electrolyte loss during exercise, uncovering relationships between sweat metrics, and tracking glucose dynamics to explore sweat-to-blood correlations in healthy and diabetic individuals. By enabling a comprehensive sweat analysis, the presented device is a crucial tool for advancing sweat testing beyond the research stage for point-of-care medical and athletic applications.",
author = "Nyein, {Hnin Yin Yin} and Mallika Bariya and Liisa Kivim{\"a}ki and Sanna Uusitalo and Liaw, {Tiffany Sun} and Elina Jansson and Ahn, {Christine Heera} and Hangasky, {John A.} and Jiangqi Zhao and Yuanjing Lin and Tuomas Happonen and Minghan Chao and Christina Liedert and Yingbo Zhao and Tai, {Li Chia} and Jussi Hiltunen and Ali Javey",
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Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat. / Nyein, Hnin Yin Yin; Bariya, Mallika; Kivimäki, Liisa; Uusitalo, Sanna; Liaw, Tiffany Sun; Jansson, Elina; Ahn, Christine Heera; Hangasky, John A.; Zhao, Jiangqi; Lin, Yuanjing; Happonen, Tuomas; Chao, Minghan; Liedert, Christina; Zhao, Yingbo; Tai, Li Chia; Hiltunen, Jussi; Javey, Ali (Corresponding Author).

In: Science advances, Vol. 5, No. 8, eaaw9906, 16.08.2019.

Research output: Contribution to journalArticleScientificpeer-review

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AU - Jansson, Elina

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AU - Lin, Yuanjing

AU - Happonen, Tuomas

AU - Chao, Minghan

AU - Liedert, Christina

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AU - Javey, Ali

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