Regional brain morphometry in patients with traumatic brain injury based on acute- and chronic-phase magnetic resonance imaging

Christian Ledig, Konstantinos Kamnitsas, Juha Koikkalainen, Jussi P. Posti, Riikka S.K. Takala, Ari Katila, Janek Frantzén, Henna Ala-Seppälä, Anna Kyllönen, Henna Riikka Maanpää, Jussi Tallus, Jyrki Lötjönen, Ben Glocker, Olli Tenovuo, Daniel Rueckert

    Research output: Contribution to journalArticleScientificpeer-review

    2 Citations (Scopus)

    Abstract

    Traumatic brain injury (TBI) is caused by a sudden external force and can be very heterogeneous in its manifestation. In this work, we analyse T1-weighted magnetic resonance (MR) brain images that were prospectively acquired from patients who sustained mild to severe TBI. We investigate the potential of a recently proposed automatic segmentation method to support the outcome prediction of TBI. Specifically, we extract meaningful cross-sectional and longitudinal measurements from acute- and chronic-phase MR images. We calculate regional volume and asymmetry features at the acute/subacute stage of the injury (median: 19 days after injury), to predict the disability outcome of 67 patients at the chronic disease stage (median: 229 days after injury). Our results indicate that small structural volumes in the acute stage (e.g. of the hippocampus, accumbens, amygdala) can be strong predictors for unfavourable disease outcome. Further, group differences in atrophy are investigated. We find that patients with unfavourable outcome show increased atrophy. Among patients with severe disability outcome we observed a significantly higher mean reduction of cerebral white matter (3.1%) as compared to patients with low disability outcome (0.7%).

    Original languageEnglish
    Article numbere0188152
    JournalPLoS ONE
    Volume12
    Issue number11
    DOIs
    Publication statusPublished - 1 Nov 2017
    MoE publication typeA1 Journal article-refereed

    Fingerprint

    Magnetic resonance
    morphometry
    magnetic resonance imaging
    Brain
    Magnetic Resonance Imaging
    brain
    Imaging techniques
    atrophy
    Atrophy
    Wounds and Injuries
    Magnetic Resonance Spectroscopy
    amygdala
    hippocampus
    Amygdala
    chronic diseases
    Hippocampus
    Chronic Disease
    Traumatic Brain Injury
    prediction
    extracts

    Keywords

    • Adolescent
    • Adult
    • Aged
    • Aged, 80 and over
    • Brain Injuries, Traumatic/diagnostic imaging
    • Cross-Sectional Studies
    • Female
    • Humans
    • Longitudinal Studies
    • Magnetic Resonance Imaging/methods
    • Male
    • Middle Aged
    • Young Adult

    Cite this

    Ledig, C., Kamnitsas, K., Koikkalainen, J., Posti, J. P., Takala, R. S. K., Katila, A., ... Rueckert, D. (2017). Regional brain morphometry in patients with traumatic brain injury based on acute- and chronic-phase magnetic resonance imaging. PLoS ONE, 12(11), [e0188152]. https://doi.org/10.1371/journal.pone.0188152
    Ledig, Christian ; Kamnitsas, Konstantinos ; Koikkalainen, Juha ; Posti, Jussi P. ; Takala, Riikka S.K. ; Katila, Ari ; Frantzén, Janek ; Ala-Seppälä, Henna ; Kyllönen, Anna ; Maanpää, Henna Riikka ; Tallus, Jussi ; Lötjönen, Jyrki ; Glocker, Ben ; Tenovuo, Olli ; Rueckert, Daniel. / Regional brain morphometry in patients with traumatic brain injury based on acute- and chronic-phase magnetic resonance imaging. In: PLoS ONE. 2017 ; Vol. 12, No. 11.
    @article{a623efac130e47628264c8b45c1173a1,
    title = "Regional brain morphometry in patients with traumatic brain injury based on acute- and chronic-phase magnetic resonance imaging",
    abstract = "Traumatic brain injury (TBI) is caused by a sudden external force and can be very heterogeneous in its manifestation. In this work, we analyse T1-weighted magnetic resonance (MR) brain images that were prospectively acquired from patients who sustained mild to severe TBI. We investigate the potential of a recently proposed automatic segmentation method to support the outcome prediction of TBI. Specifically, we extract meaningful cross-sectional and longitudinal measurements from acute- and chronic-phase MR images. We calculate regional volume and asymmetry features at the acute/subacute stage of the injury (median: 19 days after injury), to predict the disability outcome of 67 patients at the chronic disease stage (median: 229 days after injury). Our results indicate that small structural volumes in the acute stage (e.g. of the hippocampus, accumbens, amygdala) can be strong predictors for unfavourable disease outcome. Further, group differences in atrophy are investigated. We find that patients with unfavourable outcome show increased atrophy. Among patients with severe disability outcome we observed a significantly higher mean reduction of cerebral white matter (3.1{\%}) as compared to patients with low disability outcome (0.7{\%}).",
    keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Brain Injuries, Traumatic/diagnostic imaging, Cross-Sectional Studies, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging/methods, Male, Middle Aged, Young Adult",
    author = "Christian Ledig and Konstantinos Kamnitsas and Juha Koikkalainen and Posti, {Jussi P.} and Takala, {Riikka S.K.} and Ari Katila and Janek Frantz{\'e}n and Henna Ala-Sepp{\"a}l{\"a} and Anna Kyll{\"o}nen and Maanp{\"a}{\"a}, {Henna Riikka} and Jussi Tallus and Jyrki L{\"o}tj{\"o}nen and Ben Glocker and Olli Tenovuo and Daniel Rueckert",
    year = "2017",
    month = "11",
    day = "1",
    doi = "10.1371/journal.pone.0188152",
    language = "English",
    volume = "12",
    journal = "PLoS ONE",
    issn = "1932-6203",
    publisher = "Public Library of Science",
    number = "11",

    }

    Ledig, C, Kamnitsas, K, Koikkalainen, J, Posti, JP, Takala, RSK, Katila, A, Frantzén, J, Ala-Seppälä, H, Kyllönen, A, Maanpää, HR, Tallus, J, Lötjönen, J, Glocker, B, Tenovuo, O & Rueckert, D 2017, 'Regional brain morphometry in patients with traumatic brain injury based on acute- and chronic-phase magnetic resonance imaging', PLoS ONE, vol. 12, no. 11, e0188152. https://doi.org/10.1371/journal.pone.0188152

    Regional brain morphometry in patients with traumatic brain injury based on acute- and chronic-phase magnetic resonance imaging. / Ledig, Christian; Kamnitsas, Konstantinos; Koikkalainen, Juha; Posti, Jussi P.; Takala, Riikka S.K.; Katila, Ari; Frantzén, Janek; Ala-Seppälä, Henna; Kyllönen, Anna; Maanpää, Henna Riikka; Tallus, Jussi; Lötjönen, Jyrki; Glocker, Ben; Tenovuo, Olli; Rueckert, Daniel.

    In: PLoS ONE, Vol. 12, No. 11, e0188152, 01.11.2017.

    Research output: Contribution to journalArticleScientificpeer-review

    TY - JOUR

    T1 - Regional brain morphometry in patients with traumatic brain injury based on acute- and chronic-phase magnetic resonance imaging

    AU - Ledig, Christian

    AU - Kamnitsas, Konstantinos

    AU - Koikkalainen, Juha

    AU - Posti, Jussi P.

    AU - Takala, Riikka S.K.

    AU - Katila, Ari

    AU - Frantzén, Janek

    AU - Ala-Seppälä, Henna

    AU - Kyllönen, Anna

    AU - Maanpää, Henna Riikka

    AU - Tallus, Jussi

    AU - Lötjönen, Jyrki

    AU - Glocker, Ben

    AU - Tenovuo, Olli

    AU - Rueckert, Daniel

    PY - 2017/11/1

    Y1 - 2017/11/1

    N2 - Traumatic brain injury (TBI) is caused by a sudden external force and can be very heterogeneous in its manifestation. In this work, we analyse T1-weighted magnetic resonance (MR) brain images that were prospectively acquired from patients who sustained mild to severe TBI. We investigate the potential of a recently proposed automatic segmentation method to support the outcome prediction of TBI. Specifically, we extract meaningful cross-sectional and longitudinal measurements from acute- and chronic-phase MR images. We calculate regional volume and asymmetry features at the acute/subacute stage of the injury (median: 19 days after injury), to predict the disability outcome of 67 patients at the chronic disease stage (median: 229 days after injury). Our results indicate that small structural volumes in the acute stage (e.g. of the hippocampus, accumbens, amygdala) can be strong predictors for unfavourable disease outcome. Further, group differences in atrophy are investigated. We find that patients with unfavourable outcome show increased atrophy. Among patients with severe disability outcome we observed a significantly higher mean reduction of cerebral white matter (3.1%) as compared to patients with low disability outcome (0.7%).

    AB - Traumatic brain injury (TBI) is caused by a sudden external force and can be very heterogeneous in its manifestation. In this work, we analyse T1-weighted magnetic resonance (MR) brain images that were prospectively acquired from patients who sustained mild to severe TBI. We investigate the potential of a recently proposed automatic segmentation method to support the outcome prediction of TBI. Specifically, we extract meaningful cross-sectional and longitudinal measurements from acute- and chronic-phase MR images. We calculate regional volume and asymmetry features at the acute/subacute stage of the injury (median: 19 days after injury), to predict the disability outcome of 67 patients at the chronic disease stage (median: 229 days after injury). Our results indicate that small structural volumes in the acute stage (e.g. of the hippocampus, accumbens, amygdala) can be strong predictors for unfavourable disease outcome. Further, group differences in atrophy are investigated. We find that patients with unfavourable outcome show increased atrophy. Among patients with severe disability outcome we observed a significantly higher mean reduction of cerebral white matter (3.1%) as compared to patients with low disability outcome (0.7%).

    KW - Adolescent

    KW - Adult

    KW - Aged

    KW - Aged, 80 and over

    KW - Brain Injuries, Traumatic/diagnostic imaging

    KW - Cross-Sectional Studies

    KW - Female

    KW - Humans

    KW - Longitudinal Studies

    KW - Magnetic Resonance Imaging/methods

    KW - Male

    KW - Middle Aged

    KW - Young Adult

    UR - http://www.scopus.com/inward/record.url?scp=85035793930&partnerID=8YFLogxK

    U2 - 10.1371/journal.pone.0188152

    DO - 10.1371/journal.pone.0188152

    M3 - Article

    VL - 12

    JO - PLoS ONE

    JF - PLoS ONE

    SN - 1932-6203

    IS - 11

    M1 - e0188152

    ER -