Regulation of lipid metabolism in breast cancer provides diagnostic and therapeutic opportunities

Mika Hilvo (Corresponding Author), Matej Oresic

Research output: Contribution to journalArticleScientificpeer-review

11 Citations (Scopus)

Abstract

During malignant transformation, the lipid metabolism of cells changes radically and therefore alterations in lipid metabolism are a prominent feature of solid tumors. Lipid metabolism has been investigated at the gene and protein expression levels for several decades, but recent advances in lipidomics technology have also enabled the investigation of pathways at the level of molecular lipids. This review provides an overview of the changes of global lipid metabolism (i.e., fatty acid, phospholipid, eicosanoid and sphingolipid metabolism) in breast cancer, and discusses the diagnostic and therapeutic potential of these pathways.
Original languageEnglish
Pages (from-to)177-188
JournalClinical Lipidology
Volume7
Issue number2
Publication statusPublished - 2012
MoE publication typeA1 Journal article-refereed

Fingerprint

Lipid Metabolism
Breast Neoplasms
Sphingolipids
Eicosanoids
Therapeutics
Phospholipids
Fatty Acids
Technology
Lipids
Gene Expression
Neoplasms
Proteins

Keywords

  • breast cancer
  • diagnostics
  • eicosanoids
  • glycolipids
  • lipid metabolism
  • lysophosphatidic acid
  • phospholipids
  • sphingolipids
  • therapeutics

Cite this

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abstract = "During malignant transformation, the lipid metabolism of cells changes radically and therefore alterations in lipid metabolism are a prominent feature of solid tumors. Lipid metabolism has been investigated at the gene and protein expression levels for several decades, but recent advances in lipidomics technology have also enabled the investigation of pathways at the level of molecular lipids. This review provides an overview of the changes of global lipid metabolism (i.e., fatty acid, phospholipid, eicosanoid and sphingolipid metabolism) in breast cancer, and discusses the diagnostic and therapeutic potential of these pathways.",
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Regulation of lipid metabolism in breast cancer provides diagnostic and therapeutic opportunities. / Hilvo, Mika (Corresponding Author); Oresic, Matej.

In: Clinical Lipidology, Vol. 7, No. 2, 2012, p. 177-188.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Regulation of lipid metabolism in breast cancer provides diagnostic and therapeutic opportunities

AU - Hilvo, Mika

AU - Oresic, Matej

PY - 2012

Y1 - 2012

N2 - During malignant transformation, the lipid metabolism of cells changes radically and therefore alterations in lipid metabolism are a prominent feature of solid tumors. Lipid metabolism has been investigated at the gene and protein expression levels for several decades, but recent advances in lipidomics technology have also enabled the investigation of pathways at the level of molecular lipids. This review provides an overview of the changes of global lipid metabolism (i.e., fatty acid, phospholipid, eicosanoid and sphingolipid metabolism) in breast cancer, and discusses the diagnostic and therapeutic potential of these pathways.

AB - During malignant transformation, the lipid metabolism of cells changes radically and therefore alterations in lipid metabolism are a prominent feature of solid tumors. Lipid metabolism has been investigated at the gene and protein expression levels for several decades, but recent advances in lipidomics technology have also enabled the investigation of pathways at the level of molecular lipids. This review provides an overview of the changes of global lipid metabolism (i.e., fatty acid, phospholipid, eicosanoid and sphingolipid metabolism) in breast cancer, and discusses the diagnostic and therapeutic potential of these pathways.

KW - breast cancer

KW - diagnostics

KW - eicosanoids

KW - glycolipids

KW - lipid metabolism

KW - lysophosphatidic acid

KW - phospholipids

KW - sphingolipids

KW - therapeutics

M3 - Article

VL - 7

SP - 177

EP - 188

JO - Clinical Lipidology

JF - Clinical Lipidology

SN - 1758-4299

IS - 2

ER -