Relation between the content of organochlorine compounds in Finnish human milk and characteristics of the mothers

Helena Mussalo-Rauhamaa, Heikki Pyysalo, Kaija Antervo

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Abstract

Neutral organochlorine pesticide and PCB residues were analyzed by CC‐MS technique in 183 human milk samples obtained in 1984–1985 from 165 women living in different parts of Finland. The effect of the donors’ age, body mass, place of residence, number of children, dietary habits, smoking habits, occupational history, and weight loss on the organochlorine content of human milk were studied. Of all the milk samples analyzed, p,p’ ‐DDE concentrations were above the detection limit in 99.5%, p,p'‐DDD + p,p'‐DDT in 57.9%, isomers of HCH in 30.0%, cis‐chlordane in 4.9%, oxychlordane in 3.3%, trans‐nonachlor in 6.0%, heptachlor in 12.0%, and heptachlor epoxide in 6.6%. Mirex was not found in any of the milk samples, whereas the signals of chlorinated terpenes (toxaphenes) were detected but could not be quantitatively determined.
The mean fat adjusted residue levels above the detection limit in Finnish human milk samples of primipara mothers were 0.66 ppm for total DDT compounds, 0.08 ppm for HCB, 0.93 ppm for PCBs, 0.41 ppm for chlordane compounds, 0.20 ppm for isomers of HCH, and 0.10 ppm for heptachlor epoxide. The geometric means were 0.46, 0.06, 0.57, 0.02, 0.02, and 0.01 ppm, respectively.
The age of the mothers positively correlated with the DDE concentrations in human milk. The residues of OC compounds in human milk did not differ in women living in plywood industry regions, those actually working in the industry, and other mothers. Small differences were detected in the levels of organochlorine compounds in different parts of Finland. No relation was found between the OC content and the fish consumption, smoking habits, weight loss, or social group of the donors.
Original languageEnglish
Pages (from-to)1-19
JournalJournal of Toxicology and Environmental Health
Volume25
Issue number1
DOIs
Publication statusPublished - 1988
MoE publication typeA1 Journal article-refereed

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Chlorinated Hydrocarbons
Human Milk
Mothers
Heptachlor Epoxide
Dichlorodiphenyl Dichloroethylene
DDT
Polychlorinated Biphenyls
Finland
Polychlorinated biphenyls
Isomers
Habits
Limit of Detection
Weight Loss
Industry
Milk
Mirex
Heptachlor
Smoking
Chlordan
Tissue Donors

Cite this

@article{5913739dfdbf44c59e5e000208b40244,
title = "Relation between the content of organochlorine compounds in Finnish human milk and characteristics of the mothers",
abstract = "Neutral organochlorine pesticide and PCB residues were analyzed by CC‐MS technique in 183 human milk samples obtained in 1984–1985 from 165 women living in different parts of Finland. The effect of the donors’ age, body mass, place of residence, number of children, dietary habits, smoking habits, occupational history, and weight loss on the organochlorine content of human milk were studied. Of all the milk samples analyzed, p,p’ ‐DDE concentrations were above the detection limit in 99.5{\%}, p,p'‐DDD + p,p'‐DDT in 57.9{\%}, isomers of HCH in 30.0{\%}, cis‐chlordane in 4.9{\%}, oxychlordane in 3.3{\%}, trans‐nonachlor in 6.0{\%}, heptachlor in 12.0{\%}, and heptachlor epoxide in 6.6{\%}. Mirex was not found in any of the milk samples, whereas the signals of chlorinated terpenes (toxaphenes) were detected but could not be quantitatively determined. The mean fat adjusted residue levels above the detection limit in Finnish human milk samples of primipara mothers were 0.66 ppm for total DDT compounds, 0.08 ppm for HCB, 0.93 ppm for PCBs, 0.41 ppm for chlordane compounds, 0.20 ppm for isomers of HCH, and 0.10 ppm for heptachlor epoxide. The geometric means were 0.46, 0.06, 0.57, 0.02, 0.02, and 0.01 ppm, respectively. The age of the mothers positively correlated with the DDE concentrations in human milk. The residues of OC compounds in human milk did not differ in women living in plywood industry regions, those actually working in the industry, and other mothers. Small differences were detected in the levels of organochlorine compounds in different parts of Finland. No relation was found between the OC content and the fish consumption, smoking habits, weight loss, or social group of the donors.",
author = "Helena Mussalo-Rauhamaa and Heikki Pyysalo and Kaija Antervo",
year = "1988",
doi = "10.1080/15287398809531185",
language = "English",
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pages = "1--19",
journal = "Journal of Toxicology and Environmental Health",
issn = "0098-4108",
publisher = "Taylor & Francis",
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Relation between the content of organochlorine compounds in Finnish human milk and characteristics of the mothers. / Mussalo-Rauhamaa, Helena; Pyysalo, Heikki; Antervo, Kaija.

In: Journal of Toxicology and Environmental Health, Vol. 25, No. 1, 1988, p. 1-19.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Relation between the content of organochlorine compounds in Finnish human milk and characteristics of the mothers

AU - Mussalo-Rauhamaa, Helena

AU - Pyysalo, Heikki

AU - Antervo, Kaija

PY - 1988

Y1 - 1988

N2 - Neutral organochlorine pesticide and PCB residues were analyzed by CC‐MS technique in 183 human milk samples obtained in 1984–1985 from 165 women living in different parts of Finland. The effect of the donors’ age, body mass, place of residence, number of children, dietary habits, smoking habits, occupational history, and weight loss on the organochlorine content of human milk were studied. Of all the milk samples analyzed, p,p’ ‐DDE concentrations were above the detection limit in 99.5%, p,p'‐DDD + p,p'‐DDT in 57.9%, isomers of HCH in 30.0%, cis‐chlordane in 4.9%, oxychlordane in 3.3%, trans‐nonachlor in 6.0%, heptachlor in 12.0%, and heptachlor epoxide in 6.6%. Mirex was not found in any of the milk samples, whereas the signals of chlorinated terpenes (toxaphenes) were detected but could not be quantitatively determined. The mean fat adjusted residue levels above the detection limit in Finnish human milk samples of primipara mothers were 0.66 ppm for total DDT compounds, 0.08 ppm for HCB, 0.93 ppm for PCBs, 0.41 ppm for chlordane compounds, 0.20 ppm for isomers of HCH, and 0.10 ppm for heptachlor epoxide. The geometric means were 0.46, 0.06, 0.57, 0.02, 0.02, and 0.01 ppm, respectively. The age of the mothers positively correlated with the DDE concentrations in human milk. The residues of OC compounds in human milk did not differ in women living in plywood industry regions, those actually working in the industry, and other mothers. Small differences were detected in the levels of organochlorine compounds in different parts of Finland. No relation was found between the OC content and the fish consumption, smoking habits, weight loss, or social group of the donors.

AB - Neutral organochlorine pesticide and PCB residues were analyzed by CC‐MS technique in 183 human milk samples obtained in 1984–1985 from 165 women living in different parts of Finland. The effect of the donors’ age, body mass, place of residence, number of children, dietary habits, smoking habits, occupational history, and weight loss on the organochlorine content of human milk were studied. Of all the milk samples analyzed, p,p’ ‐DDE concentrations were above the detection limit in 99.5%, p,p'‐DDD + p,p'‐DDT in 57.9%, isomers of HCH in 30.0%, cis‐chlordane in 4.9%, oxychlordane in 3.3%, trans‐nonachlor in 6.0%, heptachlor in 12.0%, and heptachlor epoxide in 6.6%. Mirex was not found in any of the milk samples, whereas the signals of chlorinated terpenes (toxaphenes) were detected but could not be quantitatively determined. The mean fat adjusted residue levels above the detection limit in Finnish human milk samples of primipara mothers were 0.66 ppm for total DDT compounds, 0.08 ppm for HCB, 0.93 ppm for PCBs, 0.41 ppm for chlordane compounds, 0.20 ppm for isomers of HCH, and 0.10 ppm for heptachlor epoxide. The geometric means were 0.46, 0.06, 0.57, 0.02, 0.02, and 0.01 ppm, respectively. The age of the mothers positively correlated with the DDE concentrations in human milk. The residues of OC compounds in human milk did not differ in women living in plywood industry regions, those actually working in the industry, and other mothers. Small differences were detected in the levels of organochlorine compounds in different parts of Finland. No relation was found between the OC content and the fish consumption, smoking habits, weight loss, or social group of the donors.

U2 - 10.1080/15287398809531185

DO - 10.1080/15287398809531185

M3 - Article

VL - 25

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EP - 19

JO - Journal of Toxicology and Environmental Health

JF - Journal of Toxicology and Environmental Health

SN - 0098-4108

IS - 1

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