Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue: A GC-TOFMS based metabolomics study

Jan Budczies (Corresponding Author), Carsten Denkert, Berit M. Müller, Scarlet F. Brockmöller, Frederick Klauschen, Balasz Györffy, Manfred Dietel, Christiane Richter-Ehrenstein, Ulrike Marten, Reza M. Salek, Julian L. Griffin, Mika Hilvo, Matej Orešič, Gert Wohlgemuth, Oliver Fiehn

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Abstract

Changes in energy metabolism of the cells are common to many kinds of tumors and are considered a hallmark of cancer. Gas chromatography followed by time-of-flight mass spectrometry (GC-TOFMS) is a well-suited technique to investigate the small molecules in the central metabolic pathways. However, the metabolic changes between invasive carcinoma and normal breast tissues were not investigated in a large cohort of breast cancer samples so far.
Original languageEnglish
Article numbere334
JournalBMC Genomics
Volume13
Issue number1
DOIs
Publication statusPublished - 2012
MoE publication typeA1 Journal article-refereed

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Keywords

  • Breast cancer
  • Metabolomics
  • Gas chromatography
  • Mass spectrometry
  • Cancer detection

Cite this

Budczies, J., Denkert, C., Müller, B. M., Brockmöller, S. F., Klauschen, F., Györffy, B., Dietel, M., Richter-Ehrenstein, C., Marten, U., Salek, R. M., Griffin, J. L., Hilvo, M., Orešič, M., Wohlgemuth, G., & Fiehn, O. (2012). Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue: A GC-TOFMS based metabolomics study. BMC Genomics, 13(1), [e334]. https://doi.org/10.1186/1471-2164-13-334