Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue: A GC-TOFMS based metabolomics study

Jan Budczies (Corresponding Author), Carsten Denkert, Berit M. Müller, Scarlet F. Brockmöller, Frederick Klauschen, Balasz Györffy, Manfred Dietel, Christiane Richter-Ehrenstein, Ulrike Marten, Reza M. Salek, Julian L. Griffin, Mika Hilvo, Matej Orešič, Gert Wohlgemuth, Oliver Fiehn

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Changes in energy metabolism of the cells are common to many kinds of tumors and are considered a hallmark of cancer. Gas chromatography followed by time-of-flight mass spectrometry (GC-TOFMS) is a well-suited technique to investigate the small molecules in the central metabolic pathways. However, the metabolic changes between invasive carcinoma and normal breast tissues were not investigated in a large cohort of breast cancer samples so far.
Original languageEnglish
Article numbere334
JournalBMC Genomics
Volume13
Issue number1
DOIs
Publication statusPublished - 2012
MoE publication typeA1 Journal article-refereed

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Metabolomics
Gas Chromatography
Mass Spectrometry
Breast
Breast Neoplasms
Metabolic Networks and Pathways
Energy Metabolism
Neoplasms

Keywords

  • Breast cancer
  • Metabolomics
  • Gas chromatography
  • Mass spectrometry
  • Cancer detection

Cite this

Budczies, J., Denkert, C., Müller, B. M., Brockmöller, S. F., Klauschen, F., Györffy, B., ... Fiehn, O. (2012). Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue: A GC-TOFMS based metabolomics study. BMC Genomics, 13(1), [e334]. https://doi.org/10.1186/1471-2164-13-334
Budczies, Jan ; Denkert, Carsten ; Müller, Berit M. ; Brockmöller, Scarlet F. ; Klauschen, Frederick ; Györffy, Balasz ; Dietel, Manfred ; Richter-Ehrenstein, Christiane ; Marten, Ulrike ; Salek, Reza M. ; Griffin, Julian L. ; Hilvo, Mika ; Orešič, Matej ; Wohlgemuth, Gert ; Fiehn, Oliver. / Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue : A GC-TOFMS based metabolomics study. In: BMC Genomics. 2012 ; Vol. 13, No. 1.
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abstract = "Changes in energy metabolism of the cells are common to many kinds of tumors and are considered a hallmark of cancer. Gas chromatography followed by time-of-flight mass spectrometry (GC-TOFMS) is a well-suited technique to investigate the small molecules in the central metabolic pathways. However, the metabolic changes between invasive carcinoma and normal breast tissues were not investigated in a large cohort of breast cancer samples so far.",
keywords = "Breast cancer, Metabolomics, Gas chromatography, Mass spectrometry, Cancer detection",
author = "Jan Budczies and Carsten Denkert and M{\"u}ller, {Berit M.} and Brockm{\"o}ller, {Scarlet F.} and Frederick Klauschen and Balasz Gy{\"o}rffy and Manfred Dietel and Christiane Richter-Ehrenstein and Ulrike Marten and Salek, {Reza M.} and Griffin, {Julian L.} and Mika Hilvo and Matej Orešič and Gert Wohlgemuth and Oliver Fiehn",
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Budczies, J, Denkert, C, Müller, BM, Brockmöller, SF, Klauschen, F, Györffy, B, Dietel, M, Richter-Ehrenstein, C, Marten, U, Salek, RM, Griffin, JL, Hilvo, M, Orešič, M, Wohlgemuth, G & Fiehn, O 2012, 'Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue: A GC-TOFMS based metabolomics study', BMC Genomics, vol. 13, no. 1, e334. https://doi.org/10.1186/1471-2164-13-334

Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue : A GC-TOFMS based metabolomics study. / Budczies, Jan (Corresponding Author); Denkert, Carsten; Müller, Berit M.; Brockmöller, Scarlet F.; Klauschen, Frederick; Györffy, Balasz; Dietel, Manfred; Richter-Ehrenstein, Christiane; Marten, Ulrike; Salek, Reza M.; Griffin, Julian L.; Hilvo, Mika; Orešič, Matej; Wohlgemuth, Gert; Fiehn, Oliver.

In: BMC Genomics, Vol. 13, No. 1, e334, 2012.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue

T2 - A GC-TOFMS based metabolomics study

AU - Budczies, Jan

AU - Denkert, Carsten

AU - Müller, Berit M.

AU - Brockmöller, Scarlet F.

AU - Klauschen, Frederick

AU - Györffy, Balasz

AU - Dietel, Manfred

AU - Richter-Ehrenstein, Christiane

AU - Marten, Ulrike

AU - Salek, Reza M.

AU - Griffin, Julian L.

AU - Hilvo, Mika

AU - Orešič, Matej

AU - Wohlgemuth, Gert

AU - Fiehn, Oliver

PY - 2012

Y1 - 2012

N2 - Changes in energy metabolism of the cells are common to many kinds of tumors and are considered a hallmark of cancer. Gas chromatography followed by time-of-flight mass spectrometry (GC-TOFMS) is a well-suited technique to investigate the small molecules in the central metabolic pathways. However, the metabolic changes between invasive carcinoma and normal breast tissues were not investigated in a large cohort of breast cancer samples so far.

AB - Changes in energy metabolism of the cells are common to many kinds of tumors and are considered a hallmark of cancer. Gas chromatography followed by time-of-flight mass spectrometry (GC-TOFMS) is a well-suited technique to investigate the small molecules in the central metabolic pathways. However, the metabolic changes between invasive carcinoma and normal breast tissues were not investigated in a large cohort of breast cancer samples so far.

KW - Breast cancer

KW - Metabolomics

KW - Gas chromatography

KW - Mass spectrometry

KW - Cancer detection

U2 - 10.1186/1471-2164-13-334

DO - 10.1186/1471-2164-13-334

M3 - Article

VL - 13

JO - BMC Genomics

JF - BMC Genomics

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